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showing 10 items of 6213 documents

Elevated serum levels of IGF-binding protein 2 in patients with non-seminomatous germ cell cancer: correlation with tumor markers alpha-fetoprotein a…

2008

Background/aimsAlterations of the IGF system have been described in several different types of cancer. However, no information is available about the role of the IGF system in patients with non-seminomatous germ cell cancer.MethodsFree IGF-I, IGF-II, acid-labile subunit, and IGF-binding proteins (IGFBPs) 1–4 were analyzed by specific RIAs in 32 patients with untreated non-seminomas and compared with IGFBP levels of 38 healthy controls. Serum IGFBPs were analyzed by western ligand blotting (WLB) and immunoblotting. In 16 patients, IGFBP profiles were measured before, during, and after treatment.ResultsIn patients with testicular cancer, IGF-II levels were on average 1.44-fold higher than in …

AdultMalemedicine.medical_specialtyEndocrinology Diabetes and MetabolismProtein subunitBiologyChorionic GonadotropinInsulin-like growth factor-binding proteinHuman chorionic gonadotropinEndocrinologyTesticular NeoplasmsInsulin-Like Growth Factor IIRecurrenceInternal medicinemedicineBiomarkers TumorHumansIn patientTesticular cancerBinding proteinCancerGeneral MedicineMiddle AgedNeoplasms Germ Cell and Embryonalmedicine.diseaseUp-RegulationInsulin-Like Growth Factor Binding ProteinsInsulin-Like Growth Factor Binding Protein 2EndocrinologyInsulin-Like Growth Factor Binding Protein 3Case-Control Studiesbiology.proteinalpha-FetoproteinsOncofetal antigenProtein Processing Post-TranslationalEuropean journal of endocrinology
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Perceptual Pseudoneglect in Schizophrenia: Candidate Endophenotype and the Role of the Right Parietal Cortex

2013

Several contributions have reported an altered expression of pseudoneglect in psychiatric disorders, highlighting the existence of an anomalous brain lateralization in affected subjects. Surprisingly, no studies have yet investigated pseudoneglect in first-degree relatives (FdR) of psychiatric patients. We investigated performance on “paper and pencil” line bisection (LB) tasks in 68 schizophrenic patients (SCZ), 42 unaffected FdR, 41 unipolar depressive patients (UP), and 103 healthy subjects (HS). A subgroup of 20 SCZ and 16 HS underwent computerized LB and mental number line bisection (MNL) tasks requiring judgment of prebisected lines and numerical intervals. Moreover, we evaluated, in …

AdultMalemedicine.medical_specialtyEndophenotypesBisectionmedicine.medical_treatmentPosterior parietal cortexAudiologyFunctional LateralityLateralization of brain functionNOPerceptual DisordersYoung Adultschizophrenia brain stimulationParietal LobemedicineHumansFamilyYoung Adult; Humans; Endophenotypes; Depressive Disorder; Parietal Lobe; Schizophrenia; Adult; Case-Control Studies; Schizophrenic Psychology; Space Perception; Family; Middle Aged; Perceptual Disorders; Female; Functional Laterality; MaleSettore MED/25 - PsichiatriaDepressive DisorderSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicaTranscranial direct-current stimulationParietal lobeRegular ArticleMiddle Agedmedicine.diseasePsychiatry and Mental healthSchizophreniaCase-Control StudiesSpace PerceptionEndophenotypeLateralitySchizophreniaSchizophrenic PsychologyFemalePsychologyCognitive psychologySchizophrenia Bulletin
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Endoscopic and endoscope-assisted neurosurgical treatment of suprasellar arachnoidal cysts (Mickey Mouse cysts).

2005

Suprasellar arachnoid cysts represent less than 10% of all intracranial arachnoid cysts. Some of them may be quiescent throughout life, some may become symptomatic as they become enlarged and some disappear spontaneously. In this study we discuss the surgical strategies for endoscopic and endoscope-assisted treatment of suprasellar (Mickey Mouse) cysts and analyze the clinical results and experience collected over some years in our department upon doing these operations routinely. Between December 1996 and December 2003, 13 patients (7 female and 6 male patients), mean age 29 years, underwent endoscopic or endoscope-assisted procedures for suprasellar cysts at our department. The indication…

AdultMalemedicine.medical_specialtyEndoscopeAdolescentNeurosurgical ProceduresEpilepsyPostoperative ComplicationsMedicineHumansMinimally Invasive Surgical ProceduresCystChildCerebrospinal Fluidmedicine.diagnostic_testbusiness.industryMagnetic resonance imagingGeneral MedicineMiddle Agedmedicine.diseaseMagnetic Resonance ImagingCerebrospinal Fluid ShuntsSurgeryEndoscopyShunt (medical)Arachnoid CystsNeuroendoscopymedicine.anatomical_structureTreatment OutcomeChild PreschoolNeuroendoscopySurgeryNeurology (clinical)Subarachnoid spacebusinessMinimally invasive neurosurgery : MIN
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Detection of spontaneous echocardiographic contrast within the left atrium by transesophageal echocardiography: spontaneous echocardiographic contrast

1986

Transesophageal echocardiography was performed in 314 patients over a period of 24 months using a 3.5 MHz phased-array system fitted to the distal end of a conventional 12 mm endoscope. In 12 patients (2.6%) transesophageal echocardiography could not be performed because of adverse reaction to the gastroscopic procedure. Side effects were a transient A-V block in one patient and asthmatic attack in another. Mitral valve lesions were found in 99 of 314 patients. In 9 of these 99 patients (11%), including 1 patient with mitral valve stenosis and sinus rhythm, 2 with atrial fibrillation, 3 with disc, and 3 with porcine mitral prosthesis, spontaneous echocardiographic contrast was found within …

AdultMalemedicine.medical_specialtyEndoscopeEsophagusPostoperative ComplicationsMitral valve stenosisInternal medicineMitral valveHumansMitral Valve StenosisMedicineSinus rhythmHeart AtriaEsophagusbusiness.industryMitral Valve InsufficiencyThrombosisAtrial fibrillationGeneral MedicineIntracranial Embolism and ThrombosisMiddle Agedmedicine.diseasePeripheralmedicine.anatomical_structureEmbolismEchocardiographyHeart Valve Prosthesiscardiovascular systemCardiologyFemaleRadiologyCardiology and Cardiovascular MedicinebusinessClinical Cardiology
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Causal relationships in the variability of cardiovascular system evoked by orthostatic stress by transfer entropy.

2015

The coupling between cardiac and vascular systems in healthy volunteers, elicited by the head-up tilt test is estimated by means of transfer entropy with non-uniform embedding. The method applied to beat-to-beat recordings with heart periods and systolic blood pressure, supports the commonly accepted model, that baroreflex is the key factor in maintaining homeostatic blood distribution after tilting. However the method applied to changes of heart periods and changes of blood pressure, display switches in the driving system, from vascular in the early tilt, to cardiac just after the early tilt and back to vascular in the late tilt.

AdultMalemedicine.medical_specialtyEntropyPostureBiomedical EngineeringHealth InformaticsBlood PressureBaroreflexYoung AdultHeart RateStress PhysiologicalInternal medicineHealthy volunteersHeart ratemedicineTilt testHumans1707business.industryHeartBaroreflexBlood pressureAnesthesiaSignal ProcessingSettore ING-INF/06 - Bioingegneria Elettronica E Informaticacardiovascular systemCardiologyOrthostatic stressTransfer entropyFemalebusinessAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
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Postprandial thermogenesis and alimentary sensory stimulation in human subjects

1999

OBJECTIVE: To study the role of alimentary sensory stimulation on the thermic effect of food. SUBJECTS: Nine male healthy volunteers (age: 20-34y, body mass index (BMI): 17.4-25.3 kg/m 2 ). DESIGN AND MEASUREMENTS: Four experimental situations were investigated on different days. Subjects: 1) ate a four course meal containing 2582kJ (meal), 2) saw, smelt and tasted the same courses (alimentary sensory stimulation), 3) saw, smelt and tasted non-alimentary substances (non-alimentary sensory stimulation), 4) received directly into the stomach the previous meal (tube feeding). Energy expenditure (EE) was measured over a 20 min rest period, then for 110 min. RESULTS: The changes over midday rest…

AdultMalemedicine.medical_specialtyEpinephrineEndocrinology Diabetes and MetabolismSensationMedicine (miscellaneous)Sensory systemBody Mass IndexEatingNorepinephrineInternal medicineHumansMedicineMealNutrition and DieteticsSensory stimulation therapybusiness.industryStomachPostprandial Periodmedicine.anatomical_structureEndocrinologyPostprandialSpecific dynamic actionEnergy MetabolismbusinessThermogenesisBody mass indexBody Temperature RegulationInternational Journal of Obesity
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The Buccal Mucosal Graft For Urethral Reconstruction: A Preliminary Report

1992

Autologous buccal mucosa as a substitute for urethral epithelium was studied in 2 dogs and used in 6 patients with difficult urethral reconstruction problems. The indications for an operation in these patients were failed hypospadias repairs with limited skin in 3, severe structure disease after hypospadias repair in 1, a short urethra in 1 and epispadias in 1. Three urethral fistulas and 1 meatal stenosis occurred in 3 patients. No urethral stricture or diverticulum was noted, and the final outcome was good functionally and cosmetically in all patients. This technique is useful for urethral reconstruction when local skin is not available.

AdultMalemedicine.medical_specialtyEpispadiasAdolescentUrethral strictureUrologyEpispadiasDogsPostoperative ComplicationsUrethramedicineAnimalsHumansChildHypospadiasbusiness.industryMouth MucosaInfantBuccal administrationCheekmedicine.diseaseMeatal stenosisSurgeryPlastic surgerymedicine.anatomical_structureUrethraHypospadiasChild PreschoolSurgical Procedures OperativeTissue TransplantationbusinessJournal of Urology
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Repetitive TMS over the left dorsolateral prefrontal cortex modulates the error positivity: An ERP study

2019

Abstract Error processing is a critical step towards an efficient adaptation of our behavior to achieve a goal. Little research has been devoted to investigate the contribution of the dorsolateral prefrontal cortex (DLPFC) in supporting error processing. In this study, the causal relationship of the DLPFC in error commission was examined by means of a repetitive transcranial magnetic stimulation protocol (rTMS). Specifically, the effects of an inhibitory protocol were assessed by examining the electroencephalographic signal recorded during the execution of a Go/No-Go task. To this aim, a group of 15 healthy young participants performed a three-session study. At each session, either the righ…

AdultMalemedicine.medical_specialtyError awareness Post-error slowing (PES) Transcranial magnetic stimulation (TMS) Error positivity (Pe) Error-related negativity (ERN) Dorsolateral prefrontal cortex (DLPFC)Post-error slowing (PES)Cognitive Neurosciencemedicine.medical_treatmentPrefrontal CortexExperimental and Cognitive PsychologyStimulationAudiologyInhibitory postsynaptic potentialbehavioral disciplines and activities050105 experimental psychologyFunctional LateralityTask (project management)03 medical and health sciencesBehavioral NeuroscienceYoung Adult0302 clinical medicineTranscranial magnetic stimulation (TMS)mental disordersmedicineError positivity (Pe)Humans0501 psychology and cognitive sciencesEvoked PotentialsLeft dorsolateral prefrontal cortexError processingDorsolateral prefrontal cortex (DLPFC)05 social sciencesError awareneBrainNegativity effectElectroencephalographyAwarenessTranscranial Magnetic StimulationTranscranial magnetic stimulationDorsolateral prefrontal cortexInhibition Psychologicalmedicine.anatomical_structurenervous systemStroop TestFemaleError-related negativity (ERN)Psychologypsychological phenomena and processes030217 neurology & neurosurgery
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Carcinoma of the hypopharynx and the cervical oesophagus: a surgical challenge.

1999

To report our results after reconstruction of the upper digestive tract for locally advanced carcinoma of the hypopharynx and cervical oesophagus.Open study.Teaching University hospital, Germany.Of the 517 patients who presented with carcinoma of the oesophagus between September 1985 and March 1997, 16 had a locally advanced tumour of the hypopharynx and 25 of the cervical oesophagus.Free jejunal grafts were used after circular resection in all patients with carcinoma of the hypopharynx, and for the 3 with oesophageal carcinoma in whom we obtained adequate resection margins. In the remainder stomach was used in 21 and colon in 1.Morbidity and mortality.After jejunal grafting 1 patient died …

AdultMalemedicine.medical_specialtyEsophageal Neoplasmsmedicine.medical_treatmentAnastomosisAdenocarcinomaEsophagusPostoperative ComplicationsHypopharyngeal Neoplasmotorhinolaryngologic diseasesmedicineCarcinomaHumansHospital MortalityEsophagusSurvival rateNeoplasm StagingHypopharyngeal Neoplasmsbusiness.industryStomachdigestive oral and skin physiologyMiddle Agedmedicine.diseaseSurgeryEsophagectomySurvival RateHypopharynxmedicine.anatomical_structureJejunumEsophagectomyCarcinoma Squamous CellAdenocarcinomaSurgeryFemalebusinessThe European journal of surgery = Acta chirurgica
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Complications after superficial parotidectomy for pleomorphic adenoma

2018

Background The significance of complications after superficial parotidectomy remains unclear, since prospective studies are lacking. The aim of this study was to evaluate facial nerve dysfunction and other postoperative complications after superficial parotidectomy for pleomorphic adenoma of the superficial lobe and to identify the associated risk factors. Material and Methods Prospective and descriptive clinical study on 79 patients undergoing formal superficial parotidectomy with the modified facelift incision, dissection of the facial nerve and reconstruction with the superficial musculoaponeurotic system flap. Function of the facial nerve using the House-Brackmann scale and the intra- a…

AdultMalemedicine.medical_specialtyFacial ParalysisOral Surgical ProceduresAdenoma PleomorphicPleomorphic adenoma03 medical and health sciencesPostoperative Complications0302 clinical medicineRisk FactorsmedicineHumansParotid GlandLongitudinal StudiesProspective Studies030223 otorhinolaryngologyGeneral DentistryEarlobeAgedParesisAged 80 and overbusiness.industryResearch030206 dentistryMiddle AgedSalivary Gland Neoplasms:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseFacial nerveFacial paralysisParotid glandSurgerystomatognathic diseasesDissectionmedicine.anatomical_structureOtorhinolaryngologySuperficial ParotidectomyUNESCO::CIENCIAS MÉDICASFemaleSurgeryOral Surgerymedicine.symptombusinessMedicina Oral Patología Oral y Cirugia Bucal
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