Search results for "precision"

showing 10 items of 448 documents

The role of left supplementary motor area in grip force scaling

2013

Skilled tool use and object manipulation critically relies on the ability to scale anticipatorily the grip force (GF) in relation to object dynamics. This predictive behaviour entails that the nervous system is able to store, and then select, the appropriate internal representation of common object dynamics, allowing GF to be applied in parallel with the arm motor commands. Although psychophysical studies have provided strong evidence supporting the existence of internal representations of object dynamics, known as "internal models", their neural correlates are still debated. Because functional neuroimaging studies have repeatedly designated the supplementary motor area (SMA) as a possible …

MaleTRANSCRANIAL MAGNETIC STIMULATIONAnatomy and PhysiologyBrain activity and meditationmedicine.medical_treatmentSocial SciencesBRAIN ACTIVITYSocial and Behavioral SciencesFunctional LateralityACTIVATIONBehavioral NeuroscienceTask Performance and AnalysisHuman PerformancePsychologyMotor skillPhysicsMultidisciplinaryHand StrengthSupplementary motor areaQMotor CortexRPRECISION GRIPSMA*Transcranial Magnetic Stimulationmedicine.anatomical_structureMotor SkillsPREMOTOR AREASFMRIMedicineSensory PerceptionOBJECTSResearch ArticleMotor cortexAdultCognitive NeuroscienceScienceNeurophysiologyNeurological SystemLateralization of brain functionNeuropsychologyHand strengthPsychophysicsmedicineLearningHumansFRONTAL-LOBEBiologyMotor SystemsBehaviorMOVEMENTSCognitive PsychologyEvoked Potentials MotorHandTranscranial magnetic stimulationINTERNAL-MODELSNeuroscienceNeuroscience
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CA125-Guided Diuretic Treatment Versus Usual Care in Patients With Acute Heart Failure and Renal Dysfunction

2020

BACKGROUND: The optimal diuretic treatment strategy for patients with acute heart failure and renal dysfunction remains unclear. Plasma carbohydrate antigen 125 (CA125) is a surrogate of fluid overload and a potentially valuable tool for guiding decongestion therapy. The aim of this study was to determine if a CA125-guided diuretic strategy is superior to usual care in terms of short-term renal function in patients with acute heart failure and renal dysfunction at presentation. METHODS: This multicenter, open-label study randomized 160 patients with acute heart failure and renal dysfunction into 2 groups (1:1). Loop diuretics doses were established according to CA125 levels in the CA125-gui…

Maleendocrine system diseasesPREDICTIONmedicine.medical_treatmentUrine030204 cardiovascular system & hematologyKidney Function TestsCONGESTIONBiomarker guided-therapy0302 clinical medicineSodium Potassium Chloride Symporter InhibitorsFurosemideNatriuretic peptideMedicineRenal Insufficiency030212 general & internal medicinePrecision MedicineANTIGEN CARBOHYDRATE 125Aged 80 and overFurosemideGeneral MedicineDiuretic treatmentEUROPEAN-SOCIETYClinical trialFemaleTRIALmedicine.drugmedicine.medical_specialtyRenal failureSTRATEGIESmedicine.drug_classUrologyRenal function03 medical and health sciencesHumansIn patientAgedHeart FailureSERUM CREATININENATRIURETIC PEPTIDEbusiness.industryMORTALITYMembrane ProteinsAcute heart failuremedicine.diseaseClinical trialCarbohydrate antigen 125CA-125 AntigenHeart failureDiuretic treatmentDiureticbusinessCARDIORENAL SYNDROME
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Comparison of the gold standard of hemoglobin measurement with the clinical standard (BGA) and noninvasive hemoglobin measurement (SpHb) in small chi…

2015

Introduction Collecting a blood sample is usually necessary to measure hemoglobin levels in children. Especially in small children, noninvasively measuring the hemoglobin level could be extraordinarily helpful, but its precision and accuracy in the clinical environment remain unclear. In this study, noninvasive hemoglobin measurement and blood gas analysis were compared to hemoglobin measurement in a clinical laboratory. Methods In 60 healthy preoperative children (0.2-7.6 years old), hemoglobin was measured using a noninvasive method (SpHb; Radical-7 Pulse Co-Oximeter), a blood gas analyzer (clinical standard, BGAHb; ABL 800 Flex), and a laboratory hematology analyzer (reference method, la…

Malemedicine.medical_specialtyAccuracy and precisionHemoglobin levelsHemoglobinsPreoperative CaremedicineHumansProspective StudiesHemoglobin measurementChildBlood gas analysisbusiness.industrySmall childrenInfantReproducibility of ResultsGold standard (test)SurgeryAnesthesiology and Pain MedicineChild PreschoolPediatrics Perinatology and Child HealthFemaleObservational studyHemoglobinBlood Gas AnalysisNuclear medicinebusinessPediatric Anesthesia
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Individualized Comprehensive Lifestyle Intervention in Patients Undergoing Chemotherapy with Curative or Palliative Intent: Who Participates?

2015

Objective Knowledge about determinants of participation in lifestyle interventions in cancer patients undergoing chemotherapy, particularly with palliative intent, remains poor. The objective of the present study was to identify determinants of participating in a 12 month individualized, comprehensive lifestyle intervention, focusing on diet, physical activity, mental stress and smoking cessation, in cancer patients receiving chemotherapy with curative or palliative intent. The secondary objective was to identify participation determinants 4 months into the study. Methods Newly diagnosed cancer patients starting chemotherapy at the cancer center in Kristiansand/Norway (during a 16 month inc…

Malemedicine.medical_specialtyPalliative caremedicine.medical_treatmentlcsh:MedicineAntineoplastic AgentsBreast NeoplasmsBreast cancerInternal medicinemedicineHumansPrecision Medicinelcsh:ScienceLife StyleSocioeconomic statusAgedChemotherapyMultidisciplinarybusiness.industryPalliative Carelcsh:RProstatic NeoplasmsCancerMiddle Agedmedicine.diseaseCombined Modality TherapyPhysical therapySmoking cessationMarital statusFemaleSmoking Cessationlcsh:QColorectal NeoplasmsbusinessBody mass indexResearch ArticlePLOS ONE
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Introducing sexual dysfunction in mental care.

2020

Introduction: People with any psychiatric disorder tend to have difficulties in responding sexually. However,sexual dysfunction (SD) is usually under-recognized, even the tightly hormonal and neuro...

Malemedicine.medical_specialtyPsychotropic Drugsbusiness.industryMental DisordersGeneral Medicine030204 cardiovascular system & hematology03 medical and health sciencesSexual Dysfunction Physiological0302 clinical medicineSexual dysfunction030220 oncology & carcinogenesisQuality of LifeMedicineHumansPharmacology (medical)FemaleSexual Dysfunctions Psychologicalmedicine.symptomPrecision MedicinebusinessAdverse effectPsychiatryExpert opinion on drug safety
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A comparison of three different attachment systems for mandibular two-implant overdentures: one-year report.

2009

Background: There is a lack of clinical studies on the self-aligning attachment system (Locator®; Zest Anchors, Inc. homepage, Escondido, CA, USA) for two-implant-retained overdentures in the edentulous mandible. Therefore, a comparison of the Locator with two traditional designs (a rotational gold matrix and a rubber O-ring type) in clinical 1-year use was conducted. MaterialsandMethods: From 2003 to 2007, 60 patients received two Osseotite® TG Standard implants (BIOMET 3i Implant Innovations, Palm Beach Gardens, FL, USA) in the intraforaminal area of the edentulous mandible. The implants were left unloaded for 3.5 months, randomized to three different attachment systems, and loaded throug…

Malemedicine.medical_treatmentDenture Complete LowerDentistryDental AbutmentsOral HealthMandiblelaw.inventionDental AbutmentsRandomized controlled triallawmedicineDenture Precision AttachmentHumansJaw EdentulousProspective StudiesDental implantProspective cohort studyDenture DesignGeneral DentistryDenture RetentionAgedOrthodonticsAged 80 and overDental Implantsbusiness.industryDental prosthesisDental Implantation EndosseousMiddle AgedDenture OverlayDenture RetentionTreatment OutcomeDenture DesignQuality of LifeFemaleImplantDental Prosthesis Implant-SupportedOral SurgerybusinessClinical implant dentistry and related research
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Recommendations of the treatment-resistant depression expert center network for promoting tobacco smoking cessation based on the results from the rea…

2022

Abstract Background Tobacco smoking has been associated with suicide, impulsivity and depression in non-clinical populations with differences across sexes. Objective To determine the role of tobacco smoking in Treatment-Resistant Depression (TRD) according to sex in a precision-medicine approach. Method The FACE-TRD cohort is a national cohort of TRD patients recruited in 13 resistant depression expert centers between 2014 and 2021 and followed-up at 6 months. A standardized one-day long comprehensive battery was carried out, including trained-clinician and patient-reported outcomes, and patients were reevaluated at 6 months on their smoking and psychiatric hospitalization outcomes. Results…

Malemedicine.medical_treatmentMESH: Tobacco SmokingSuicide AttemptedtobaccoMESH: NicotineCohort StudiesDepressive Disorder Treatment-Resistantchemistry.chemical_compoundSurveys and QuestionnairesMedicinePrecision MedicineVareniclineMESH: Cohort StudiesDepression (differential diagnoses)health care economics and organizationseducation.field_of_studypublic mental healthMESH: Middle AgedMESH: Suicidal Ideationpublic healthMiddle AgedMESH: Smoking CessationpsychiatryCohortdepressionMESH: Suicide AttemptedFemalemental healthNicotinemedicine.medical_specialtyPopulationeducationMESH: Precision MedicinesmokingSuicidal IdeationMESH: Depressive Disorder Treatment-ResistantSex FactorsMESH: Sex FactorsTobacco SmokingHumansMESH: Surveys and QuestionnaireseducationPsychiatryBiological PsychiatryPharmacologyMESH: HumansSuicide attemptbusiness.industryOdds ratiomedicine.diseaseMESH: Maleschizophreniachemistry[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental healthSmoking cessationSmoking CessationbusinessTreatment-resistant depressionMESH: Female
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Comparative Study by Numerical Analysis on the Formability of Deep-Drawn Tailor-Welded Blanks

2012

The realising of complex parts by welding together and then deep-drawing metal sheets made of different steel types or even different metal types can have many advantages, such as decreasing the part’s weight, reducing the manufacturing costs and an increased dimensional precision. In order to benefit from these results, a detailed knowledge of the metal sheets’ behaviour during deep-drawing is necessary. The current paper aims to compare, using numerical simulations based on the finite element method, the deep-drawing behaviour of parts made of steel sheets of different thicknesses welded together in three different manners and also of a part made of a monoblock blank.

Materials scienceComputer simulationbusiness.industryNumerical analysisGeneral EngineeringWeldingStructural engineeringBlankFinite element methodlaw.inventionDimensional precisionlawFormabilityDeep drawingbusinessAdvanced Materials Research
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The second round of Critical Assessment of Automated Structure Determination of Proteins by NMR: CASD-NMR-2013

2015

The second round of the community-wide initiative Critical Assessment of automated Structure Determination of Proteins by NMR (CASD-NMR-2013) comprised ten blind target datasets, consisting of unprocessed spectral data, assigned chemical shift lists and unassigned NOESY peak and RDC lists, that were made available in both curated (i.e. manually refined) or un-curated (i.e. automatically generated) form. Ten structure calculation programs, using fully automated protocols only, generated a total of 164 three-dimensional structures (entries) for the ten targets, sometimes using both curated and un-curated lists to generate multiple entries for a single target. The accuracy of the entries could…

Models MolecularProtein ConformationBiochimieProton Magnetic Resonance SpectroscopyDatasets as TopicBiochemistryArticleBlind testingAutomationCASD-NMRValidationSpectroscopie [état condense]Carbon-13 Magnetic Resonance SpectroscopyNuclear Magnetic Resonance BiomolecularStructure determinationSpectroscopyAccuracyautomationNOEaccuracyProteinChemical shiftProteinsReproducibility of ResultsPrecisionQualityNMRPRECISIONSpectroscopie [électromagnétisme optique acoustique]qualityprotein
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Identification of potential inhibitors targeting BRAF-V600E mutant melanoma cells.

2020

Models MolecularProto-Oncogene Proteins B-rafProtein ConformationMutantMutation MissenseDermatologyInhibitory Concentration 50Structure-Activity RelationshipCell Line TumormedicineHumansPoint MutationMolecular Targeted TherapyPrecision MedicineMelanomaProtein Kinase InhibitorsDose-Response Relationship Drugbusiness.industryMelanomaDrug Repositioningmedicine.diseaseNeoplasm ProteinsBRAF V600EMolecular Docking SimulationAmino Acid SubstitutionDrug DesignCancer researchIdentification (biology)Drug Screening Assays AntitumorbusinessJournal of the American Academy of Dermatology
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