Search results for "precision"
showing 10 items of 448 documents
Virtual Clinical and Precision Medicine Tumor Boards-Cloud-Based Platform-Mediated Implementation of Multidisciplinary Reviews Among Oncology Centers…
2021
Background Multidisciplinary tumor boards play a pivotal role in the patient-centered clinical management and in the decision-making process to provide best evidence-based, diagnostic, and therapeutic care to patients with cancer. Among the barriers to achieve an efficient multidisciplinary tumor board, lack of time and geographical distance play a major role. Therefore, the elaboration of an efficient virtual multidisciplinary tumor board (VMTB) is a key point to successfully obtain an oncology team and implement a network among health professionals and institutions. This need is stronger than ever during the COVID-19 pandemic. Objective This paper presents a research protocol for an obse…
B-mode versus A-mode ultrasonographic measurements of mucosal thickness in vivo
2002
Abstract Objective: The objective of this study was to compare the measurement accuracy of A-mode and B-mode ultrasonographic assessments of palatal masticatory mucosal thickness in vivo. Study Design: Thickness of palatal masticatory mucosa in the molar region of 50 volunteers was measured once with a B-mode ultrasound device (10 MHz) combined with a standoff for intraoral applications. At identical reading points thickness was also assessed with an A-mode device (5 replicates) and by needle probing for determination of true thickness. Results: On average true thickness ranged between 2.9 and 3.3 mm (95% confidence intervals; median, 3.1 mm). B-mode ultrasonography overestimated truth by 0…
Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions
2016
Melanoma treatment has been revolutionized by antibody-based immunotherapies. IFNγ secretion by CD8+ T cells is critical for therapy efficacy having anti-proliferative and pro-apoptotic effects on tumour cells. Our study demonstrates a genetic evolution of IFNγ resistance in different melanoma patient models. Chromosomal alterations and subsequent inactivating mutations in genes of the IFNγ signalling cascade, most often JAK1 or JAK2, protect melanoma cells from anti-tumour IFNγ activity. JAK1/2 mutants further evolve into T-cell-resistant HLA class I-negative lesions with genes involved in antigen presentation silenced and no longer inducible by IFNγ. Allelic JAK1/2 losses predisposing to …
Epigenetics in spine curvature disorders
2022
Abstract Scoliosis is a three-dimensional (3D) structural deformity of the spine with a radiological lateral Cobb angle of ≥ 10°. Several classification systems exist, dividing different types regarding the age of onset or the type of etiology. The minority of cases are secondary to congenital, syndromic of neuromosucular diseases. Most of the cases are classified “idiopathic” due to unknown etiology. These were formally divided by the age of onset into “Infantile Idiopathic Scoliosis” (0–3 years), “Juvenile Idiopathic Scoliosis” (JIS—4–10 years), and “Adolescent Idiopathic Scoliosis” (AIS → 10 years). Since the initiative of the Scoliosis Research Society in 2014 all kind of scoliosis with…
Diet and Neurocognition in Mood Disorders - an Overview of the Overlooked.
2019
Bipolar disorder and major depression are associated with significant disability, morbidity, and reduced life expectancy. People with mood disorders have shown higher ratios of unhealthy lifestyle choices, including poor diet quality and suboptimal nutrition. Diet and nutrition impact on brain /mental health, but cognitive outcomes have been less researched in psychiatric disorders. Neurocognitive dysfunction is a major driver of social dysfunction and a therapeutic target in mood disorders, although effective cognitive-enhancers are currently lacking. This narrative review aimed to assess the potential cognitive benefits of dietary and nutritional interventions in subjects diagnosed with m…
PINGU: a vision for neutrino and particle physics at the South Pole
2017
The Precision IceCube Next Generation Upgrade (PINGU) is a proposed low-energy in-fill extension to the IceCube Neutrino Observatory. With detection technology modeled closely on the successful IceCube example, PINGU will provide a 6Mton effective mass for neutrino detection with an energy threshold of a few GeV. With an unprecedented sample of over 60,000 atmospheric neutrinos per year in this energy range, PINGU will make highly competitive measurements of neutrino oscillation parameters in an energy range over an order of magnitude higher than long-baseline neutrino beam experiments. PINGU will measure the mixing parameters $\theta_{\rm 23}$ and $\Delta m^2_{\rm 32}$, including the octan…
The electron self-energy in QED at two loops revisited
2018
We reconsider the two-loop electron self-energy in quantum electrodynamics. We present a modern calculation, where all relevant two-loop integrals are expressed in terms of iterated integrals of modular forms. As boundary points of the iterated integrals we consider the four cases $p^2=0$, $p^2=m^2$, $p^2=9m^2$ and $p^2=\infty$. The iterated integrals have $q$-expansions, which can be used for the numerical evaluation. We show that a truncation of the $q$-series to order ${\mathcal O}(q^{30})$ gives numerically for the finite part of the self-energy a relative precision better than $10^{-20}$ for all real values $p^2/m^2$.
Precision mass measurements of antiprotons in a Penning trap
1992
Utilizing electron cooling, the TRAP collaboration has lowered the energy at which antiprotons can be stored and studied by more than 10 orders of magnitude, starting with 6 MeV particles from LEAR. We have held cryogenic antiprotons a few degrees above absolute zero for two months and the storage lifetime so established, more than 3.4 months is the longest directly measured limit for antiprotons. Measuring their cyclotron frequencies in a precision cylindrical Penning trap, we have shown that the inertial masses of the antiprotons and protons are the same to a fractional accuracy of 4 parts in 108, a 1000-fold improvement over the previous comparisons. This is the most stringent test of CP…
The H-graph with equal masses in terms of multiple polylogarithms
2021
The initial phase of the inspiral process of a binary system producing gravitational waves can be described by perturbation theory. At the third post-Minkowskian order a two-loop double box graph, known as H-graph contributes. We consider the case where the two objects making up the binary system have equal masses. We express all master integrals related to the equal-mass H-graph up to weight four in terms of multiple polylogarithms. We provide a numerical program which evaluates all master integrals up to weight four in the physical regions with arbitrary precision.
Reactor antineutrino detection in Double Chooz experiment: Techniques for background reduction
2014
Abstract A crucial task for the Double Chooz reactor antineutrino experiment is the thorough study of the different backgrounds in the detector. Newly developed background reduction techniques minimize the impact of the backgrounds on our sensitivity. Moreover, only a precision and accuracy measurement of the residual background would allow to measure the mixing angle θ 13 with high precision. Neutrino coincidence signals are imitated by signals produced in several others physics processes: accidental coincidences of single events (accidental background), as well as correlated events induced by cosmic muons, including stopping muons, fast neutrons and spallation isotopes Li 9 /He 8 . The Do…