Search results for "precursor"
showing 10 items of 490 documents
Influence of blood sampling from venipunctures and catheter systems on serial determinations of prothrombin activation fragment 1 + 2 and thrombin-an…
1993
To evaluate the influence of different blood sampling techniques on test results of thrombin-antithrombin III complex (TAT) and prothrombin fragment 1 + 2 (F1 + 2) serial determinations were performed. In six groups of nonrandomized patients (ten patients each) the concentrations of the coagulation markers of blood samples from central catheters (internal jugular, caval, Shaldon, pulmonary artery) and peripheral cannulas (17G and 18G) were compared with those of blood samples obtained simultaneously from direct venipunctures of the contralateral arm. Medians and 25th-75th percentiles of TAT and F1 + 2 concentrations of plasmas obtained from central catheters were not different from those ta…
Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo.
2011
Identification of physiologically relevant substrates is still the most challenging part in protease research for understanding the biological activity of these enzymes. The zinc-dependent metalloprotease meprin β is known to be expressed in many tissues with functions in health and disease. Here, we demonstrate unique interactions between meprin β and the amyloid precursor protein (APP). Although APP is intensively studied as a ubiquitously expressed cell surface protein, which is involved in Alzheimer disease, its precise physiological role and relevance remain elusive. Based on a novel proteomics technique termed terminal amine isotopic labeling of substrates (TAILS), APP was identified …
Influence of extracellular matrix proteins on the development of cultured human dendritic cells.
1998
The development of dendritic cells (DC) is still only partly understood. Recently established culture systems using CD34+ cells or monocytes as precursor cells for the generation of DC indicate the necessity of pro-inflammatory cytokines for their development. In vivo the contact to other cells or to the proteins of the extracellular matrix might also be essential for their development. In our experiments we used granulocyte-macrophage colony-stimulating factor- and IL-4-treated human monocytes as precursor cells to investigate the interaction of DC at different maturation stages with the matrix proteins fibronectin, collagen type I and collagen type IV. We demonstrate a strong beta1-integr…
Mesenchymal Stem Cells Provide Better Results Than Hematopoietic Precursors for the Treatment of Myocardial Infarction
2010
Objectives The purpose of this study was to compare the ability of human CD34(+) hematopoietic stem cells and bone marrow mesenchymal stem cells (MSC) to treat myocardial infarction (MI) in a model of permanent left descendent coronary artery (LDA) ligation in nude rats. Background Transplantation of human CD34(+) cells and MSC has been proved to be effective in treating MI, but no comparative studies have been performed to elucidate which treatment prevents left ventricular (LV) remodelling more efficiently. Methods Human bone marrow MSC or freshly isolated CD34(+) cells from umbilical cord blood were injected intramyocardially in infarcted nude rats. Cardiac function was analyzed by echoc…
Precursori di Deficit dell'Attenzione e disturbi di iperattività (ADHD) in bambini moderatamente pretermine di età prescolare
2013
Lo studio presentato ha voluto esplorare la possibile presenza in bambini di etŕ prescolare, nati moderatamente pretermine, di precursori del disturbo da deficit dell'attenzione e iperattivitŕ. La ricerca ha coinvolto un gruppo di 50 bambini (etŕ media = 5 anni e 2 mesi, ds = 4 mesi) nati moderatamente pretermine (etŕ gestazionale media = 34 settimane, ds = 2) senza complicanze mediche neonatali e con basso peso alla nascita (media = 2100 g., ds = 350 g.) e 50 bambini nati a ter - mine in assenza di complicanze pre e perinatali (etŕ gestazionale media = 40 settimane). Ai genitori e agli insegnanti delle scuole di riferimento dei bambini sono stati somministrati specifici questionari (Identi…
Prerequisiti e indicatori di difficoltà di apprendimento in bambini moderatamente pretermine di età prescolare
2012
Lo studio riportato intende per un verso confermare e per altro esplorare la possibile presenza, in bambini di età prescolare nati moderatamente pretermine, di difficoltà relative a specifiche abilità cognitive che, secondo il modello di lettura assunto, sono funzionali all'apprendimento prescolastico; nello specifico, vengono individuati come risultati attesi di tale obiettivo, bassi livelli di prestazioni relative ad abilità generali che attengono all'"idoneità di apprendimento" e, quindi, alla capacità di comprensione ed espressione linguistica, di metacognizione e altre abilità legate alla memoria, all'orientamento e alla coordinazione motoria e visuomotoria, così come a capacità specif…
Search for Gravitational Waves Associated with Gamma-Ray Bursts Detected by Fermi and Swift during the LIGO-Virgo Run O3a
2022
Abbott, R., et al. (LIGO and VIRGO Collaboration)
Los precursores de la baja atención e hiperactividad en niños moderadamente y muy prematuros en edad preescolar
2013
Abstract La escasa atención e hiperactividad son las morbilidades asociadas con el nacimiento muy prematuro y moderadamente. El objetivo del estudio es investigar la posible presencia de los primeros precursores de Déficit de Atención e Hiperactividad (TDAH) en niños muy prematuros y moderadamente en la edad preescolar. Los niños participantes fueron: 25 niños muy prematuros (M = 29,4 semanas de edad gestacional, SD = 2), con bajo peso al nacer, 35 niños moderadamente prematuros (M = 1.200 g, SD = 250 g.).: 34,6 semanas de edad gestacional, SD: 1) con bajo peso al nacer (M: 2100g, SD:.. 250 g), 60 niños sanos a término como grupo control. Los padres de los niños se administraron cuestionari…
Sobre los sueños de Aristóteles
2020
Título Sobre los sueños de Aristóteles Introducción El tema general de mi trabajo de investigación trata sobre la psicología de Aristóteles, enfocada en el aspecto de los sueños. Pero, en la medida que el soñar es un fenómeno que ocurre durante el sueño, y ambos están mutuamente relacionados, es inevitable tratar también el tema del sueño. Así pues, el núcleo de mi trabajo está basado en De Insomniis, que forma un todo indivisible con De Somno et Vigilia, y De Divinatione per Somnum, en los tratados Parva Naturalia de Aristóteles. Es más, como estamos tratando con la psicología, el telón de fondo general será el De Anima, base de las ideas psicológicas de nuestro autor, y texto de referenci…
Photoluminescent Detection of Human T-Lymphoblastic Cells by ZnO Nanorods.
2020
The precise detection of cancer cells currently remains a global challenge. One-dimensional (1D) semiconductor nanostructures (e.g., ZnO nanorods) have attracted attention due to their potential use in cancer biosensors. In the current study, it was demonstrated that the possibility of a photoluminescent detection of human leukemic T-cells by using a zinc oxide nanorods (ZnO NRs) platform. Monoclonal antibodies (MABs) anti-CD5 against a cluster of differentiation (CD) proteins on the pathologic cell surface have been used as a bioselective layer on the ZnO surface. The optimal concentration of the protein anti-CD5 to form an effective bioselective layer on the ZnO NRs surface was selected. …