Search results for "predictive value"

showing 10 items of 927 documents

Added Value of Multiparametric Magnetic Resonance Imaging to Clinical Nomograms for Predicting Adverse Pathology in Prostate Cancer

2018

PURPOSE: We examined the additional value of preoperative prostate multiparametric magnetic resonance imaging and transrectal ultrasound/multiparametric magnetic resonance imaging fusion guided targeted biopsy when performed in combination with clinical nomograms to predict adverse pathology at radical prostatectomy. MATERIALS AND METHODS: We identified all patients who underwent 3 Tesla multiparametric magnetic resonance imaging prior to fusion biopsy and radical prostatectomy. The Partin and the MSKCC (Memorial Sloan Kettering Cancer Center) preradical prostatectomy nomograms were applied to estimate the probability of organ confined disease, extraprostatic extension, seminal vesicle inva…

Image-Guided BiopsyMalePathologymedicine.medical_specialtyUrologymedicine.medical_treatment030232 urology & nephrologyMagnetic Resonance Imaging InterventionalRisk AssessmentArticle03 medical and health sciencesProstate cancer0302 clinical medicinePredictive Value of TestsProstatePreoperative CareImage Processing Computer-AssistedmedicineHumansProspective StudiesUltrasonography InterventionalMultiparametric Magnetic Resonance ImagingAgedRetrospective Studiesbusiness.industryProstatectomyProstateProstatic NeoplasmsMiddle AgedNomogrammedicine.diseaseMagnetic Resonance ImagingPI-RADSProstate-specific antigenNomogramsmedicine.anatomical_structure030220 oncology & carcinogenesisFeasibility StudiesBiopsy Large-Core NeedleNeoplasm GradingbusinessImage-Guided Biopsyhuman activities
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Prospective Evaluation of PI-RADS™ Version 2 Using the International Society of Urological Pathology Prostate Cancer Grade Group System

2017

The PI-RADS™ (Prostate Imaging Reporting and Data System), version 2 scoring system, introduced in 2015, is based on expert consensus. In the same time frame ISUP (International Society of Urological Pathology) introduced a new pathological scoring system for prostate cancer. Our goal was to prospectively evaluate the cancer detection rates for each PI-RADS, version 2 category and compare them to ISUP group scores in patients undergoing systematic biopsy and magnetic resonance imaging-transrectal ultrasound fusion guided biopsy.A total of 339 treatment naïve patients prospectively underwent multiparametric magnetic resonance imaging evaluated with PI-RADS, version 2 with subsequent systemat…

Image-Guided BiopsyMalemedicine.medical_specialtyPathologyUrology030232 urology & nephrology030218 nuclear medicine & medical imaging03 medical and health sciencesProstate cancer0302 clinical medicinePredictive Value of TestsProstateBiopsymedicineMedical imagingHumansProspective StudiesMultiparametric Magnetic Resonance ImagingAgedUltrasonographymedicine.diagnostic_testbusiness.industryProstatic NeoplasmsMagnetic resonance imagingMiddle Agedmedicine.diseaseMagnetic Resonance ImagingPI-RADSProstate-specific antigenmedicine.anatomical_structureRadiologyNeoplasm GradingbusinessJournal of Urology
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Correlation between IgA tissue transglutaminase antibody ratio and histological finding in celiac disease.

2011

OBJECTIVES: Positivity of both immunoglobulin A anti-tissue transglutaminase (TTG) and anti-endomysium antibodies (EMA) has a positive predictive value of nearly 100% for celiac disease (CD). The objective of the present study was to evaluate whether patients of any age, with high pretest probability of CD and high titre of anti-TTG and EMA positivity, have a high probability of intestinal damage and may not require the biopsy for final diagnosis. METHODS: A retrospective analysis of 412 consecutively referred patients, age range 10 months to 72 years, who underwent small-bowel biopsy for suspicion of CD and positivity to both anti-TTG and EMA, was performed at 4 Italian centers. Biopsies w…

Immunoglobulin AAdultMalemedicine.medical_specialtyPathologyAdolescentTissue transglutaminaseDuodenumBiopsySettore MED/08 - Anatomia PatologicaGastroenterologySeverity of Illness IndexCoeliac diseaseStatistics NonparametricYoung AdultCoeliac disease Transglutaminase antibodyGTP-Binding ProteinsPredictive Value of TestsInternal medicineSeverity of illnessBiopsymedicineHumansProtein Glutamine gamma Glutamyltransferase 2ChildAgedRetrospective StudiesSettore MED/12 - GastroenterologiaTransglutaminasesbiologymedicine.diagnostic_testbusiness.industryMusclesGastroenterologyInfantRetrospective cohort studyMiddle Agedmedicine.diseaseImmunoglobulin APre- and post-test probabilityCeliac DiseaseLogistic ModelsPredictive value of testsChild PreschoolPediatrics Perinatology and Child Healthbiology.proteinFemalebusinessJournal of pediatric gastroenterology and nutrition
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Epidemiology of intra-abdominal infection and sepsis in critically ill patients: "AbSeS", a multinational observational cohort study and ESICM Trials…

2019

Pardo-Oviedo, Juan Mauricio/0000-0003-0084-3449; Lopez-Delgado, Juan Carlos/0000-0003-3324-1129; Corradi, Francesco/0000-0002-5588-2608; De Backer, Daniel/0000-0001-9841-5762; POTA, VINCENZO/0000-0001-9999-3388; Tomescu, Dana/0000-0001-9673-5754; Sabetian, Golnar/0000-0001-8764-2150; Girardis, Massimo/0000-0002-2453-0829; Brazzi, Luca/0000-0001-7059-0622; Leone, Marc/0000-0002-3097-758X; Zabolotskikh, Igor Borisovich/0000-0002-3623-2546; De Lange, Dylan/0000-0002-0191-7270; ALMEKHLAFI, GHALEB A./0000-0002-0323-7025; Elke, Gunnar/0000-0002-4948-1605; Grigoras, Ioana/0000-0001-9412-9574; Czuczwar, Miroslaw/0000-0002-9025-6717; Nora, David/0000-0002-1133-7368; Masjedi, Mansoor/0000-0001-6175-9…

Infection riskMaleBIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences.Antibiotic resistanceTracte gastrointestinal - MalaltiesDefinitionsCritical Care and Intensive Care MedicineTHERAPYDEFINITIONS:Infections::Intraabdominal Infections [DISEASES]0302 clinical medicineIntensive care; Intra-abdominal infection; Mortality; Multidrug resistance; Peritonitis; Sepsis;[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseasesObservational studySeptic shockIntensive care; Intra-abdominal infection; Mortality; Multidrug resistance; Peritonitis; SepsisComputingMilieux_MISCELLANEOUSCritical Illness/epidemiology[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseasesBIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti.Intraabdominal Infections/epidemiologyAbdominal infectionMulticenter study3. Good healthManagementClinical trialCohort[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/VirologyCohort analysisCommunity acquired infectionCohort studyHumanmedicine.medical_specialtyCarbapenem resistanceCritical IllnessPeritoneal dialysisPeritonitisVancomycin resistant enterococcusMajor clinical studyPeritonitisArticle03 medical and health sciencesAntibiotic resistance[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemIntensive careSepsisSettore MED/41 - ANESTESIOLOGIAHumansCritical care medicineHospital infectionAgedScience & TechnologyLiver failureAntibiotic therapymedicine.disease[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/BacteriologyEpidemiologic Studies030228 respiratory systemIntensive Care Unit; Sepsis (Diptera); Septic ShockRisk factorHuman medicineGeneral & internal medicineCongestive heart failureOriginalMultidrug resistanceCohort StudiesRisk FactorsCause of DeathEpidemiologyPrevalenceMedicine and Health SciencesAbdominal abscessSepsis/epidemiologyMiddle agedAntifungal therapy2. Zero hungerPeritonitiAntibiotic agentBiliary tract infectionIntensive care ; Intra-abdominal infection ; Mortality ; Multidrug resistance ; Peritonitis ; SepsisMiddle Aged:infecciones bacterianas y micosis::infección::infecciones intraabdominales [ENFERMEDADES]PREVALENCE:Infections::Sepsis [DISEASES]:técnicas de investigación::métodos epidemiológicos::características de los estudios epidemiológicos::estudios epidemiológicos::estudios de cohortes [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS]Methicillin resistant staphylococcus aureusRaonament basat en casosFemaleCritically ill patientLife Sciences & BiomedicineAntifungal agentAdult:Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics::Epidemiologic Studies::Cohort Studies [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT]Predictive value:infecciones bacterianas y micosis::infección::sepsis [ENFERMEDADES]NOSepsisIntra-abdominal infectionCritical Care MedicineInternal medicineGeneral & Internal MedicinemedicineMANAGEMENTJournal Article[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/ParasitologySepticèmiaMortalitybusiness.industrySeptic shockPancreas diseaseMalnutrition030208 emergency & critical care medicineTyphlitisToxic megacolonIntensive careIntraabdominal InfectionsTherapyLate onset disorderbusiness
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A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature

2009

Objective: To create a genomic tool composed of a customized microarray and a bioinformatic predictor for endometrial dating and to detect pathologies of endometrial origin. To define the transcriptomic signature of human endometrial receptivity. Design: Two cohorts of endometrial samples along the menstrual cycle were used: one to select the genes to be included in the customized microarray (endometrial receptivity array [ERA]), and the other to be analyzed by ERA to train the predictor for endometrial dating and to define the transcriptomic signature. A third cohort including pathological endometrial samples was used to train the predictor for pathological classification. Setting: Healthy…

InfertilityMicroarraymedia_common.quotation_subjectpredictorEndometriumBioinformaticsSensitivity and SpecificityTranscriptomeEndometriumPredictive Value of Teststranscriptomic signaturemedicineCluster AnalysisHumansPathologicalMenstrual cycleHydrosalpinxMenstrual Cyclemedia_commonUterine Diseasesbusiness.industryReverse Transcriptase Polymerase Chain ReactionGene Expression ProfilingObstetrics and GynecologyReproducibility of Resultsendometrial datingGenomicsmedicine.diseasemedicine.anatomical_structureEndometrial receptivityReproductive MedicineFemaleEndometrial receptivitybusinessmicroarrayInfertility Femalediagnostic tool
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Laryngeal Mask Airway Position and the Risk of Gastric Insufflation

1998

A potential risk of the laryngeal mask airway (LMA) is an incomplete mask seal causing gastric insufflation or oropharyngeal air leakage.The objective of the present study was to assess the incidence of LMA malpositions by fiberoptic laryngoscopy, and to determine their influence on gastric insufflation and oropharyngeal air leakage. One hundred eight patients were studied after the induction of anesthesia, before any surgical manipulations. After clinically satisfactory LMA placement, tidal volumes were increased stepwise until air entered the stomach, airway pressure exceeded 40 cm H2 O, or air leakage from the mask seal prevented further increases in tidal volume. LMA position in relatio…

InsufflationLarynxAdultMalemedicine.medical_specialtyLaryngoscopyOropharynxEpiglottisSensitivity and SpecificityLaryngeal MasksLaryngeal mask airwayPredictive Value of TestsRisk FactorsmedicineConfidence IntervalsOdds RatioPhotographyPressureTidal VolumeFiber Optic TechnologyHumansSingle-Blind MethodTidal volumemedicine.diagnostic_testLaryngoscopybusiness.industryAirIncidenceStomachAirway obstructionmedicine.diseaseSurgeryAirway ObstructionLaryngeal Masksmedicine.anatomical_structureBronchoscopesLogistic ModelsAnesthesiology and Pain MedicineAnesthesiaEquipment FailureFemaleAirwaybusinessAnesthesia & Analgesia
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Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collabora…

2018

PubMed: 30270054

International CooperationMÉTODOS EPIDEMIOLÓGICOS030204 cardiovascular system & hematologyNationwide surveyGlobal HealthHealth Services AccessibilityDoenças Cardio e Cérebro-vascularesMOLECULAR-GENETICS0302 clinical medicineRisk FactorsPrevalenceCARDIOVASCULAR RISK-FACTORS030212 general & internal medicineCooperative BehaviorDEFECTIVE APOLIPOPROTEIN B-100GENERAL-POPULATIONeducation.field_of_studymedicine.diagnostic_testAnticholesteremic AgentsFamilial hypercholesterolaemia; FHSC; Primary dyslipidaemia; Anticholesteremic Agents; Biomarkers; Cholesterol LDL; Cooperative Behavior; Genetic Predisposition to Disease; Health Care Surveys; Health Services Accessibility; Healthcare Disparities; Humans; Hyperlipoproteinemia Type II; Phenotype; Predictive Value of Tests; Prevalence; Risk Factors; Treatment Outcome; Blood Component Removal; Global Health; International CooperationEAS Familial Hypercholesterolaemia Studies Collaboration3. Good healthPREVALENCECholesterolPhenotypeTreatment OutcomeBlood Component RemovalCORONARY-ARTERY-DISEASENATIONWIDE SURVEYCardiology and Cardiovascular MedicineFamilial hypercholesterolaemiamedicine.medical_specialtyCardiovascular risk factorsPopulationLDL-RECEPTOR1102 Cardiovascular Medicine And HaematologyLDLHyperlipoproteinemia Type II03 medical and health sciencesPredictive Value of TestsmedicineHumans:Medicine [Science]Genetic Predisposition to DiseasePrimary dyslipidaemiaHealthcare Disparitiesfhsc; familial hypercholesterolaemia; primary dyslipidaemiaeducationGenetic testingGovernmentPublic healthEAS Familial Hypercholesterolaemia Studies Collaboration (FHSC) InvestigatorsSAFEHEART REGISTRY1103 Clinical SciencesFHSCCholesterol LDLCardiovascular System & HematologyFamily medicineHealth Care Surveys3121 General medicine internal medicine and other clinical medicineCardiovascular System & CardiologyBusinessFOLLOW-UPBiomarkers
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Flow-cytometric screening for the modulation of receptor-mediated endocytosis in human dendritic cells: implications for the development of an in vit…

1997

The aim of this study was to explore the usefulness of human blood dendritic cells (DC) in the development of an in vitro model for predictive testing of contact sensitizers. A method was established to monitor the influence of chemicals on the intracellular targeting of antibody-crosslinked MHC class II molecules after their uptake by human DC. Using a three-colour flow-cytometric technique, freshly prepared DC were distinguished from other MHC class II-bearing cell types such as B-cells and monocytes in unseparated mononuclear cell suspensions of healthy volunteers. The assay is based on the pH-sensitivity of internalized fluorescein-coupled MHC class II specific antibodies. Quenching of …

Intracellular Fluidmedia_common.quotation_subjectImmunologyFluorescencechemistry.chemical_compoundPredictive Value of TestsIn vivoMHC class IDithranolmedicineHumansImmunology and AllergyReceptors ImmunologicInternalizationmedia_commonMHC class IIbiologyChemistryAntibodies MonoclonalDendritic CellsHLA-DR AntigensDendritic cellHydrogen-Ion ConcentrationFlow CytometryFluoresceinsEndocytosisIn vitroImidazolidinyl ureaImmunologybiology.proteinBiophysicsHaptensmedicine.drugJournal of Immunological Methods
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Pilot Study on Predictive Value of Plasmatic Levels of 9 Angiogenetic Biomarkers in Selection of Patients Candidate to Prostate Biopsy

2013

To reduce the number of negative prostate biopsies in patients with elevated PSA serum levels represents a major challenge in urological oncology. Angiogenetic factors might be involved in initial stages of prostate cancer and might represent useful tools in patients’ selection for prostate biopsy. The plasmatic levels of Angiopoietin-2, Follistatin, G-CSF, HGF, IL-8, Leptin, PDGF-BB, PECAM-1 and VEGF were measured by BioPlex immunoassay in patients undergoing prostate biopsy for palpable prostate nodule and/or elevated PSA levels (≥4 ng/mL). They were related with biopsy results. ROC curve analysis was exploited to test the diagnostic accuracy of each biomarker by AUC calculation. A poten…

LeptinMaleOncologymedicine.medical_specialtyPathologyProstate biopsyBiopsyPilot ProjectsAdenocarcinomaUrological oncologyProstate cancerPredictive Value of TestsProstateInternal medicineBiomarkers TumormedicineHumansIn patientAngiogenic ProteinsAgedAged 80 and overProstatic Intraepithelial Neoplasiamedicine.diagnostic_testbusiness.industryPatient SelectionProstateProstatic NeoplasmsGeneral MedicineMiddle AgedProstate-Specific Antigenmedicine.diseaseElevated PSAPredictive valuemedicine.anatomical_structureROC CurveArea Under CurveNeoplasm GradingbusinessUrologia Journal
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Predictors of leptin concentration and association with cardiovascular risk in patients with coronary artery disease: results from the AtheroGene stu…

2016

AbstractContext: Leptin is produced in white adipose tissue, but also in human coronary atherosclerotic lesions.Objective: The aim of this study is to assess the prognostic value of leptin in patients with proven coronary artery disease (CAD) (N = 1907).Methods: AtheroGene is a contemporary CAD cohort study (N = 3229). Median follow-up time was 3.8 (Quartile 1/3 with 2.8/4.9) years.Results: Leptin concentration was associated with a hazard ratio (HR) for the fully adjusted model of HR = 1.32 in women but was not significant in men. The endpoint cardiovascular death and non-fatal myocardial infarction was observed in 167 patients.Conclusion: In women with known CAD, increased leptin concentr…

LeptinMalemedicine.medical_specialtyHealth Toxicology and MutagenesisClinical BiochemistryMyocardial Infarction030209 endocrinology & metabolismCoronary Artery DiseaseWhite adipose tissue030204 cardiovascular system & hematologyRisk AssessmentBiochemistryCohort StudiesCoronary artery disease03 medical and health sciencesSex Factors0302 clinical medicinePredictive Value of TestsInternal medicinemedicineHumansMyocardial infarctionAgedProportional Hazards ModelsProportional hazards modelbusiness.industryLeptinHazard ratioMiddle Agedmedicine.diseaseCardiovascular DiseasesPredictive value of testsCardiologyFemalebusinessFollow-Up StudiesCohort studyBiomarkers
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