Search results for "pret"
showing 10 items of 2250 documents
Computer simulations of bioequivalence trials: selection of design and analyte in BCS drugs with first-pass hepatic metabolism: linear kinetics (I).
2008
Modeling and simulation approaches are useful tools to assess the potential outcome of different scenarios in bioequivalence studies. The aim of this study is to propose a new and improved semi-physiological model for bioequivalence trial simulations and apply it for all BCS (Biopharmaceutic Classification System) drug classes with non-saturated first-pass hepatic metabolism. The semi-physiological model was developed in NONMEM VI to simulate bioequivalence trials. Parent drug and metabolite levels for both reference and test were simulated. Eight types of drugs (with high or low permeability and high or low solubility (class I to IV) and high or low intrinsic clearance) were considered in …
Rapid in vitro test to predict ocular tissue permeability based on biopartitioning micellar chromatography.
2003
The drug permeability prediction across the ocular tissues is important in the development of new drugs and drug delivery strategies. Physicochemical characteristics of drugs, mainly acid-base character, hydrophobicity and the molecular size determine both their transport across the eye tissue barriers and their retention in biopartitioning micellar chromatography (BMC). An in vitro model able to describe and predict the whole cornea drug permeability is proposed. The model uses the retention of drugs in BMC and molecular weight (MW) as predictive variables. The relationships between drug retention data in BMC and their bibliographic permeability values in stroma, epithelium-plus-stroma and…
Interpretation of Ocular Melanin Drug Binding Assays. Alternatives to the Model of Multiple Classes of Independent Sites
2016
Melanin has a high binding affinity for a wide range of drugs. The determination of the melanin binding capacity and its binding affinity are important, e.g., in the determination of the ocular drug distribution, the prediction of drug effects in the eye, and the trans-scleral drug delivery. The binding parameters estimated from a given data set vary significantly when using different isotherms or different nonlinear fitting methods. In this work, the commonly used bi-Langmuir isotherm, which assumes two classes of independent sites, is confronted with the Sips isotherm. Direct, log-log, and Scatchard plots are used, and the interpretation of the binding curves in the latter is critically a…
Importance and methodologies of endodontic microleakage studies: A systematic review
2017
Introduction It is very important to obtain a tight seal in obturated root canal, making it necessary to conduct clinical or laboratory studies on the sealability of endodontic materials. Different methodologies have been historically used to assess microleakage of different endodontic materials. The aim of the present study was to comprehensively review different material testing methods used in microleakage studies, their interpretation and importance in endodontic literature. Material and methods A systematic search was conducted in Medline, Cochrane, and Web of Science databases. In addition, the reference lists of review articles on the topic were searched. No language restriction was …
Analysis of documentary and terminological needs of doctors and medical translators as a basis for the development of a next-generation multilingual …
2014
En el presente trabajo se plantea el diseño de un recurso lexicográfico multilingüe orientado a médicos y traductores médicos. En la actualidad, no existe ningún recurso que satisfaga a ambos colectivos por igual, debido a que estos poseen necesidades muy diferentes. Sin embargo, partimos de la premisa de que se podría crear una herramienta única, modular, adaptable y flexible, que responda a sus diversas expectativas, necesidades y preferencias. Se parte para ello de un análisis de necesidades siguiendo el método empírico de recogida de datos en línea mediante una encuesta trilingüe. The objective of this study is to develop a multilingual lexicographical resource aimed at doctors and medi…
Eiropas vienotā viedokļa (European Consensus) jēdziens un problemātika Eiropas Cilvēktiesību tiesas judikatūrā
2018
Eiropas Cilvēktiesību tiesai ir būtisks uzdevums interpretēt Cilvēktiesību un pamatbrīvību aizsardzības konvencijā nostiprinātās vērtības atbilstoši mūsdienu apstākļiem un pārmaiņām Eiropas sabiedrībā. Viens no risinājumiem, kādā veidā ir iespējams nodrošināt tiesu prakses attīstību, izšķirot strīdus par politiski un morāli sensitīviem jautājumiem, ir Eiropas vienotā viedokļa jeb Eiropas konsensusa identificēšana un piemērošana. Eiropas Cilvēktiesību tiesa konstatē Eiropas konsensusa esamību, veidojot Eiropas Padomes dalībvalstu salīdzinošo normatīvo aktu un prakses analīzi, un izvērtējot, vai pastāv kopīgas tendences vai vienots pamats noteikta jautājuma risināšanā. Situācijā, kādā tiesa n…
Language Mediation and Aspects of Accommodation in the Use of ELF
2014
There are numerous varieties of English spoken in Italy today, each repre-sented by one or more of the various migrant communities living in the country. These manifestations of World englishes reflect a wide range of lexical, syntactical, phonetic, pragmatic, interpersonal and cultural features. This paper argues that an interpreter or language mediator trained in standard English may not necessarily be able to comprehend or make him/herself understood adequately in other varieties of English. Thus, the recruitment of mediators/interpreters requires a certain amount of caution in terms of language choice. In order to investigate intelligibility, comprehensibility and accommodation in the c…
Beginning Becoming: The First 1000 Days
2019
Thomas Balmes’ (Babies. Studio Canal documentaries, 2010) ‘Babies’ (Baby(ies) or Bebes) provides a glimpse into the earliest experiences of four infants from four different localities in the world. Although this movie offers no interpretation of what takes place, the discerning viewer is left in no doubt of the significance of these powerful images about infants and their ways of being, doing and knowing in the earliest phases of life. The provocations of ‘Babies’ offer a useful beginning orienting place for a book – almost 10 years later – that promises to focus on becoming in the first 1000 days across a different set of five countries – this time Australia, Finland, New Zealand, Norway a…
Equidad y educación de la primera infancia en la agenda educativa mundial
2019
Resumen (descriptivo): El presente trabajo se inspira en la necesidad de abordar un análisis de la equidad en la etapa de educación infantil desde un enfoque holístico, para contribuir al debate actual sobre la importancia de la equidad en la nueva agenda educativa y sus metas para la primera infancia. Parte de fundamentos del estudio teórico de la equidad en educación desde un enfoque holístico que permita aplicar este análisis a la educación de la primera infancia en las sociedades iberoamericanas, en aras de aportar una perspectiva más amplia en la discusión de sus logros y desafíos. Finalmente, este entendimiento posibilita la interpretación de los límites y posibilidades de los objetiv…
The adoption of market-based practices within care for older people: is the work satisfaction of Nordic care workers at risk?
2011
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