Search results for "primordial."
showing 10 items of 43 documents
To Be or Not to Be a Germ Cell: The Extragonadal Germ Cell Tumor Paradigm
2021
In the human embryo, the genetic program that orchestrates germ cell specification involves the activation of epigenetic and transcriptional mechanisms that make the germline a unique cell population continuously poised between germness and pluripotency. Germ cell tumors, neoplasias originating from fetal or neonatal germ cells, maintain such dichotomy and can adopt either pluripotent features (embryonal carcinomas) or germness features (seminomas) with a wide range of phenotypes in between these histotypes. Here, we review the basic concepts of cell specification, migration and gonadal colonization of human primordial germ cells (hPGCs) highlighting the analogies of transcriptional/epigene…
Influence of pions and hyperons on stellar black hole formation
2013
We present numerical simulations of stellar core-collapse with spherically symmetric, general relativistic hydrodynamics up to black hole formation. Using the CoCoNuT code, with a newly developed grey leakage scheme for the neutrino treatment, we investigate the effects of including pions and \Lambda-hyperons into the equation of state at high densities and temperatures on the black hole formation process. Results show non-negligible differences between the models with reference equation of state without any additional particles and models with the extended ones. For the latter, the maximum masses supported by the proto-neutron star are smaller and the collapse to a black hole occurs earlie…
Narrowing the window of inflationary magnetogenesis
2017
We consider inflationary magnetogenesis where the conformal symmetry is broken by the term $f^2(\phi) F_{\alpha\beta} F^{\alpha\beta}$. We assume that the magnetic field power spectrum today between 0.1 and $10^4$ Mpc is a power law, with upper and lower limits from observation. This fixes $f$ to be close to a power law in conformal time in the window during inflation when the modes observed today are generated. In contrast to previous work, we do not make any assumptions about the form of $f$ outside these scales. We cover all possible reheating histories, described by an average equation of state $-1/3 <\bar{w} <1$. Requiring that strong coupling and large backreaction are avoided both at…
The First Three Seconds: a Review of Possible Expansion Histories of the Early Universe
2020
It is commonly assumed that the energy density of the Universe was dominated by radiation between reheating after inflation and the onset of matter domination 54,000 years later. While the abundance of light elements indicates that the Universe was radiation dominated during Big Bang Nucleosynthesis (BBN), there is scant evidence that the Universe was radiation dominated prior to BBN. It is therefore possible that the cosmological history was more complicated, with deviations from the standard radiation domination during the earliest epochs. Indeed, several interesting proposals regarding various topics such as the generation of dark matter, matter-antimatter asymmetry, gravitational waves,…
Implications for dark matter direct detection in the presence of LIGO-motivated primordial black holes
2019
We discuss formation of dark matter (DM) mini-halos around primordial black holes (PBHs) and its implication on DM direct detection experiments, including axion searches. Motivated by LIGO observations, we consider $f_{\textrm{DM}} \simeq 0.01$ as the fraction of DM in PBHs with masses $10 M_{\odot} - 70 M_{\odot}$. In this case, we expect the presence of dressed PBHs after Milky Way halo formation with mini-halo masses peaked around $M_{\textrm{halo}} \sim (50-55) M_{\textrm{PBH}}$. We analyze the effect of tidal forces acting on dressed PBHs within the Milky Way galaxy. In the solar neighborhood, the mini-halos are resistant against tidal disruption from the mean-field potential of the ga…
On gravitational waves in Born-Infeld inspired non-singular cosmologies
2017
We study the evolution of gravitational waves for non-singular cosmological solutions within the framework of Born-Infeld inspired gravity theories, with special emphasis on the Eddington-inspired Born-Infeld theory. We review the existence of two types of non-singular cosmologies, namely bouncing and asymptotically Minkowski solutions, from a perspective that makes their features more apparent. We study in detail the propagation of gravitational waves near these non-singular solutions and carefully discuss the origin and severity of the instabilities and strong coupling problems that appear. We also investigate the role of the adiabatic sound speed of the matter sector in the regularisatio…
Primordial odontogenic tumor: An immunohistochemical profile.
2017
Background Primordial Odontogenic Tumor (POT) is a recently described odontogenic tumor characterized by a variably cellular loose fibrous tissue with areas similar to the dental papilla, covered by cuboidal to columnar epithelium that resembles the internal epithelium of the enamel organ, surrounded at least partly by a delicate fibrous capsule. The purpose of this study was to investigate the possible histogenesis and biological behavior of this rare tumor by means of a wide immunohistochemical analysis of its epithelial and mesenchymal components. Material and Methods The immunoexpression of twenty-three different antibodies were evaluated in four cases of POT. Results The epithelial cel…
Bounds on very low reheating scenarios after Planck
2015
9 pages.- 9 figures
Updated BBN bounds on the cosmological lepton asymmetry for non-zero 13
2011
We discuss the bounds on the cosmological lepton number from Big Bang Nucleosynthesis (BBN), in light of recent evidences for a large value of the neutrino mixing angle theta13. The largest asymmetries for electron and muon or tau neutrinos compatible with 4He and 2H primordial yields are computed versus the neutrino mass hierarchy and mixing angles. The flavour oscillation dynamics is traced till the beginning of BBN and neutrino distributions after decoupling are numerically computed. The latter contains in general, non thermal distortion due to the onset of flavour oscillations driven by solar squared mass difference in the temperature range where neutrino scatterings become inefficient …
Human brain organoids assemble functionally integrated bilateral optic vesicles
2021
During embryogenesis, optic vesicles develop from the diencephalon via a multistep process of organogenesis. Using induced pluripotent stem cell (iPSC)-derived human brain organoids, we attempted to simplify the complexities and demonstrate formation of forebrain-associated bilateral optic vesicles, cellular diversity, and functionality. Around day 30, brain organoids attempt to assemble optic vesicles, which develop progressively as visible structures within 60 days. These optic vesicle-containing brain organoids (OVB-organoids) constitute a developing optic vesicle's cellular components, including primitive corneal epithelial and lens-like cells, retinal pigment epithelia, retinal progeni…