Search results for "primordial."
showing 10 items of 43 documents
Osteodysplastic primordial dwarfism (ODPD): notes on brain imaging
1998
Lepton flavor asymmetries and the mass spectrum of primordial black holes
2020
We study the influence of lepton flavour asymmetries on the formation and the mass spectrum of primordial black holes. We estimate the detectability of their mergers with LIGO/Virgo and show that the currently published gravitational wave events may actually be described by a primordial black hole spectrum from non-zero asymmetries. We suggest to use gravitational-wave astronomy as a novel tool to probe how lepton flavour asymmetric the Universe has been before the onset of neutrino oscillations.
Constraining the primordial black hole abundance with 21-cm cosmology
2019
The discoveries of a number of binary black hole mergers by LIGO and VIRGO has reinvigorated the interest that primordial black holes (PBHs) of tens of solar masses could contribute non-negligibly to the dark matter energy density. Should even a small population of PBHs with masses $\gtrsim \mathcal{O}(M_\odot)$ exist, they could profoundly impact the properties of the intergalactic medium and provide insight into novel processes at work in the early Universe. We demonstrate here that observations of the 21cm transition in neutral hydrogen during the epochs of reionization and cosmic dawn will likely provide one of the most stringent tests of solar mass PBHs. In the context of 21cm cosmolog…
Primordial Black Holes and Slow-Roll Violation
2017
For primordial black holes (PBH) to be the dark matter in single-field inflation, the slow-roll approximation must be violated by at least ${\cal O}(1)$ in order to enhance the curvature power spectrum within the required number of efolds between CMB scales and PBH mass scales. Power spectrum predictions which rely on the inflaton remaining on the slow-roll attractor can fail dramatically leading to qualitatively incorrect conclusions in models like an inflection potential and misestimate the mass scale in a running mass model. We show that an optimized temporal evaluation of the Hubble slow-roll parameters to second order remains a good description for a wide range of PBH formation models …
Accretion-induced quasinormal mode excitation of a Schwarzschild black hole
2007
By combining the numerical solution of the nonlinear hydrodynamics equations with the solution of the linear inhomogeneous Zerilli-Moncrief and Regge-Wheeler equations we investigate the properties of the gravitational radiation emitted during the axisymmetric accretion of matter onto a Schwarzschild black hole. The matter models considered include quadrupolar dust shells and thick accretion disks, permitting us to simulate situations which may be encountered at the end stages of stellar gravitational collapse or binary neutron star merger. We focus on the interference pattern appearing in the energy spectra of the emitted gravitational waves and on the amount of excitation of the quasi-nor…
Signatures of primordial black hole dark matter at DUNE and THEIA
2021
Primordial black holes (PBHs) are a potential dark matter candidate whose masses can span over many orders of magnitude. If they have masses in the $10^{15}-10^{17}$ g range, they can emit sizeable fluxes of MeV neutrinos through evaporation via Hawking radiation. We explore the possibility of detecting light (non-)rotating PBHs with future neutrino experiments. We focus on two next generation facilities: the Deep Underground Neutrino Experiment (DUNE) and THEIA. We simulate the expected event spectra at both experiments assuming different PBH mass distributions and spins, and we extract the expected 95% C.L. sensitivities to these scenarios. Our analysis shows that future neutrino experime…
Origine ed evoluzione dei genomi: dal brodo primordiale al DNA umano
2011
Per una migliore comprensione dell’origine e dell’evoluzione dei genomi è conveniente posizionare l’inizio e il decorso di tale processo all’interno della successione di evoluzioni che partono dall’origine dell’universo e che ancora oggi non si possono, per definizione, ritenere conclusi. Il Big Bang conclude l’evoluzione cosmica universale e dà origine all’evoluzione planetaria con la formazione dei sistemi solari ed i loro pianeti. Considerando il nostro sistema solare, e la terra in particolare, l’evoluzione geotermica, il raffreddamento del pianeta, fornisce una condizione fisica opportuna ad un’evoluzione chimica che, a conclusione, porta al brodo primordiale. Le molecole semplici poss…
Extensive nuclear gyration and pervasive non-genic transcription during primordial germ cell development in zebrafish.
2020
ABSTRACT Primordial germ cells (PGCs) are the precursors of germ cells, which migrate to the genital ridge during early development. Relatively little is known about PGCs after their migration. We studied this post-migratory stage using microscopy and sequencing techniques, and found that many PGC-specific genes, including genes known to induce PGC fate in the mouse, are only activated several days after migration. At this same time point, PGC nuclei become extremely gyrated, displaying general broad opening of chromatin and high levels of intergenic transcription. This is accompanied by changes in nuage morphology, expression of large loci (PGC-expressed non-coding RNA loci, PERLs) that ar…
Etnia/etnicità
2015
Breve profilo sulla storia degli studi e sugli approcci teorici riguardanti i concetti di etnia e etnicità scritto specificamente come scheda di approfondimento per la seconda edizione riveduta di R. H. Robbins, Antropologia culturale. Un approccio per problemi (seconda edizione italiana a cura di G. D’Agostino e V. Matera), Novara, UTET Università Brief profile on the history of studies and theoretical approaches regarding the concepts of ethnicity and ethnicity written specifically as a background file for the second revised edition of R. H. Robbins, Cultural Anthropology. An approach to problems (second Italian edition edited by G. D'Agostino and V. Matera), Novara, UTET University
Progenitor death drives retinal dysplasia and neuronal degeneration in a mouse model of Atrip-Seckel syndrome
2020
ABSTRACT Seckel syndrome is a type of microcephalic primordial dwarfism (MPD) that is characterized by growth retardation and neurodevelopmental defects, including reports of retinopathy. Mutations in key mediators of the replication stress response, the mutually dependent partners ATR and ATRIP, are among the known causes of Seckel syndrome. However, it remains unclear how their deficiency disrupts the development and function of the central nervous system (CNS). Here, we investigated the cellular and molecular consequences of ATRIP deficiency in different cell populations of the developing murine neural retina. We discovered that conditional inactivation of Atrip in photoreceptor neurons …