Search results for "privat"
showing 10 items of 2994 documents
Short telomere length is associated with impaired cognitive performance in European ancestry cohorts
2017
AbstractThe association between telomere length (TL) dynamics on cognitive performance over the life-course is not well understood. This study meta-analyses observational and causal associations between TL and six cognitive traits, with stratifications on APOE genotype, in a Mendelian Randomization (MR) framework. Twelve European cohorts (N=17 052; mean age=59.2±8.8 years) provided results for associations between qPCR-measured TL (T/S-ratio scale) and general cognitive function, mini-mental state exam (MMSE), processing speed by digit symbol substitution test (DSST), visuospatial functioning, memory and executive functioning (STROOP). In addition, a genetic risk score (GRS) for TL includin…
Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subse…
2018
Despite transferrin being the main circulating carrier of iron in body fluids, and iron overload conditions being known to worsen stroke outcome through reactive oxygen species (ROS)-induced damage, the contribution of blood transferrin saturation (TSAT) to stroke brain damage is unknown. The objective of this study was to obtain evidence on whether TSAT determines the impact of experimental ischemic stroke on brain damage and whether iron-free transferrin (apotransferrin, ATf)-induced reduction of TSAT is neuroprotective. We found that experimental ischemic stroke promoted an early extravasation of circulating iron-loaded transferrin (holotransferrin, HTf) to the ischemic brain parenchyma.…
Effects of PSA Removal from NCAM on the Critical Period Plasticity Triggered by the Antidepressant Fluoxetine in the Visual Cortex.
2016
Neuronal plasticity peaks during critical periods of postnatal development and is reduced towards adulthood. Recent data suggests that windows of juvenile-like plasticity can be triggered in the adult brain by antidepressant drugs such as Fluoxetine. Although the exact mechanisms of how Fluoxetine promotes such plasticity remains unknown, several studies indicate that inhibitory circuits play an important role. The polysialylated form of the neural cell adhesion molecules (PSA-NCAM) has been suggested to mediate the effects of Fluoxetine and it is expressed in the adult brain by mature interneurons. Moreover, the enzymatic removal of PSA by neuroaminidase-N not only affects the structure of…
Association of interleukin-6 rs1800796 polymorphism with reduced cognitive performance in healthy older adults
2019
© 2018 Elsevier B.V. With increasing life expectancy, age-associated cognitive impairment is an escalating problem worldwide. Inflammation is one of the features that characterises cognitive decline and can stimulate neurodegeneration. Interleukin 6 (IL-6) is a cytokine frequently associated with a pro-inflammatory phenotype and increased levels have been associated with the pathogenesis of dementia. The rs1800796 polymorphism in the promoter region of IL-6 gene was previously shown to influence IL-6 expression and therefore we hypothesised this gene polymorphism would be associated with IL-6 plasma levels and cognitive performance of older adults. The present study investigated the associa…
Crucial role for Nox2 and sleep deprivation in aircraft noise-induced vascular and cerebral oxidative stress, inflammation, and gene regulation
2018
Abstract Aims Aircraft noise causes endothelial dysfunction, oxidative stress, and inflammation. Transportation noise increases the incidence of coronary artery disease, hypertension, and stroke. The underlying mechanisms are not well understood. Herein, we investigated effects of phagocyte-type NADPH oxidase (Nox2) knockout and different noise protocols (around-the-clock, sleep/awake phase noise) on vascular and cerebral complications in mice. Methods and results C57BL/6j and Nox2 −/− (gp91phox −/−) mice were exposed to aircraft noise (maximum sound level of 85 dB(A), average sound pressure level of 72 dB(A)) around-the-clock or during sleep/awake phases for 1, 2, and 4 days. Adverse effec…
Longevity and risk factors of post restorations after up to 15 years: A practice-based study.
2020
Abstract Introduction The aims of this multicenter, practice-based cohort study were to evaluate the success and survival of endodontically treated teeth with post restorations (ETT+Ps) and to analyze factors associated with the longevity of ETT+Ps. Methods Eight general dental practitioners each placed up to 27 ETT+Ps without any restriction to post materials or dimensions. Only incisors, canines, and premolars were included. At the last follow-up visit, ETT+Ps were considered as successful if the post and the initially placed definitive restoration were sufficient, whereas ETT+Ps were considered as survived if the post was still in function. Multilevel Cox proportional hazards models were…
Sleep, alertness and alertness management among commercial airline pilots on short-haul and long-haul flights
2016
Item does not contain fulltext Airline pilots' sleep and on-duty alertness are important focus areas in commercial aviation. Until now, studies pertaining to this topic have mainly focused on specific characteristics of flights and thus a comprehensive picture of the matter is not well established. In addition, research knowledge of what airline pilots actually do to maintain their alertness while being on duty is scarce. To address these gaps in research knowledge, we conducted a field study on a representative sample of the airline pilots of a medium-sized airline. The sample consisted of 90 pilots, of whom 30 flew long-haul (LH) routes, 30 short-haul (SH) routes, and 30 flew both. A tota…
Gated Housing Estates in the Arab World: Case Studies in Lebanon and Riyadh, Saudi Arabia
2002
The authors analyze the cultural, economic, and political background of new gated housing estates in the Arab world with the aid of case studies in Lebanon and Riyadh. Their question is to what extent these developments represent a reappearance of the fragmented settlement patterns in many of the old towns. On the one hand, new compounds of several villas and common facilities housing extended families in Riyadh may be interpreted as a revival of certain sociospatial settings in the old town, in which extended families often shared a common courtyard. The compounds for Western foreigners in Saudi Arabia follow the principle of spatial seclusion of social groups with different cultural and r…
Material Deprivation: a Case of Latvia
2021
Material deprivation has recently gained prominence as a topic of debate as its proliferation is raising throughout Europe in particular in the countries hit hardest by financial and economic turbulences what leads to the gap in material deprivation levels throughout Europe. The aim of the study is to analyze material deprivation in the regions of Latvia. Research methods used in preparation of the paper: scientific publication and previous conducted research results analysis, analysis of anonimised data of EU-SILC survey results and European Central Bank conducted survey on Household income and expenses survey results, results are compared with the results of other EU countries. Survey ano…
Developing an Analytical Framework for Analyzing and Comparing National E-Government Strategies
2020
Part 1: E-Government Foundations; International audience; Across the world, e-government strategies are developed for the effective digitalization of the public sector. They offer governments a framework for dealing with challenges such as technical and legal interoperability and collaboration between public and private sector stakeholders, and for promoting a future vision for a digital public sector. Since e-government strategies are policy document and, thus, likely to convey biased perspectives, analyses of these strategies can yield insights into these biases and different perspectives on public sector digitalization. Until now, there has been no widely recognized framework for systema…