Search results for "proPO"
showing 10 items of 1325 documents
Inhibition of Saccharomyces cerevisiae Pdr5p by a natural compound extracted from Brazilian Red Propolis
2011
Multidrug resistance of cancer cells and pathogenic microorganisms leading to the treatment failure of some forms of cancer or life-threatening bacterial or fungal infections is often caused by the overexpression of multidrug efflux pumps belonging to the ATP-binding cassette transporters superfamily. The multidrug resistance of fungal cells often involves the overexpression of efflux pumps belonging to the pleiotropic drug resistance (PDR) family of ABC transporters. Possibly the best-studied fungal PDR transporter is the multidrug resistance transporter Pdr5p of Saccharomyces cerevisiae. Some research groups have been searching for new inhibitors of these efflux pumps in order to alleviat…
PER LA PRIMA VOLTA IL LIMITE ITALIANO AL SUBAPPALTO AL VAGLIO DELLA CORTE DI GIUSTIZIA
2018
Per la prima volta, con l’ordinanza n. 148 dello scorso 19 gennaio 2018 del TAR Lombardia, sez. I, è stata rimessa alla Corte di giustizia la validità della normativa italiana ex art. 105, comma 2, terzo periodo del d.lgs. n. 50/2016 che fissa il limite del 30% al subappalto. La questione, però, non è nuova né a livello interno, né a livello europeo.
3D Printing : Challenging Existing Business Models
2016
Technologies labelled as “disruptive” challenge conventional business procedures. The development of 3D printing technology and additive manufacturing (AM) is expected to transform product design and manufacturing. 3D printing technology makes it possible to produce complex and unique physical products from digitally designed CAD models. It is estimated that the effects of 3D printing on business will be diverse and far‐reaching. Hence, it is vital for business owners to observe how 3D printing may impact on business models and business networks, considering also the effects on stakeholders’ value propositions and on value creation. This paper reports on the potential impact of 3D printing …
Exploring the impact of sustainable value proposition on firm performance
2022
Considering the immense potential of sustainable business models in tackling the broader challenge of corporate sustainability, this paper integrates the literature streams on sustainability practices and organizational business models to analyze the performance implications of a firm's sustainable value proposition. Based on the analysis of a large panel dataset across different industries, consistent with the proposed theory, a sustainable value proposition has been found to have a positive impact on a firm's market-based financial performance (namely, Tobin's Q). Yet, this impact turns out to be highly context-dependent. In particular, the findings reveal that a firm's R&D capabilities i…
Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses
2019
The present work aimed to explain the differences in oral performance in fasted humans who were categorized into groups based on the three different drug product formulations of dexketoprofen trometamol (DKT) salt&mdash
Changes in Oxidative Stress Index and Lipid Peroxidation Product in the Brain of Rats with Lesion of Central Dopaminergic System after Propofol Admin…
2019
Propofol is a commonly used intravenous anesthetic agent with antioxidant properties. However, the effect of propofol on oxidative stress index (OSI) and lipid peroxidation in Parkinson’s disease is still unknown. The present study aimed to evaluate the effect of propofol on OSI and malondialdehyde (MDA) level in the selected brain regions of the rats with Parkinson’s disease (PD). 32 male Wistar rats were divided into four groups: I- control group, II- group with PD, III-control group with propofol, IV-PD group with propofol. 60mg/kg of propofol was given to the 8-weeks-old rats intraperitoneally, and the selected parts of the rats’ brains (frontal cortex, striatum, thalamus and hippocampu…
Changes in Oxidative Stress Index and Lipid Peroxidation Product in the Brain of Rats with Lesion of Central Dopaminergic System after Propofol Admin…
2019
Propofol is a commonly used intravenous anesthetic agent with antioxidant properties. However, the effect of propofol on oxidative stress index (OSI) and lipid peroxidation in Parkinson’s disease is still unknown. The present study aimed to evaluate the effect of propofol on OSI and malondialdehyde (MDA) level in the selected brain regions of the rats with Parkinson’s disease (PD). 32 male Wistar rats were divided into four groups: I- control group, II- group with PD, III-control group with propofol, IV-PD group with propofol. 60mg/kg of propofol was given to the 8-weeks-old rats intraperitoneally, and the selected parts of the rats’ brains (frontal cortex, striatum, thalamus and hippocampu…
La re-constitución del objeto mental "relativamente" en futuros maestros
2017
Investigaciones precedentes manifiestan que muchos estudiantes para maestro no adquieren adecuadamente los conceptos de razón y proporción (Ben-Chaim, Keret e Ilany, 2012; Valverde, 2012). Estos estudiantes parecen no tener bien constituidos ciertos objetos mentales que, de acuerdo con Fernández (2009), pueden considerarse precursores de estos conceptos. Esto puede ser debido a que este tópico no se enseña bien, que parece asentarse con un enfoque precario, pobre y breve desconectado de la realidad (Streefland, 1985). En este sentido, esta tesis doctoral estudia el ensayo de una experiencia didáctica con futuros maestros, centrada en la resolución de una tarea donde interviene implícitament…
Does Car Sharing Contribute to Urban Sustainability from User-Motivation Perspectives?
2021
Mobility, its current state and development perspectives in the future creates challenges with respect to sustainability, the first of which is the uncontrolled increase in greenhouse gas emissions in the last few decades, while road transport is one of the “sinners” creating long-term negative impact. The second is the dominance of car travel and car usage in the passenger transportation segment before the latest COVID-19 pandemic accelerated environmental problems. Although recent trends show new, greener patterns in consumption, there is still a relatively low share of consumers acknowledging the importance of sustainable and green preferences. This research study aims to investigate car…
Awareness and partitional information structures
1994
This is the first of two papers where we present a formal model of unawareness. We contrast unawareness with certainty and uncertainty. A subject is certain of something when he knows that thing; he is uncertain when he does not know it, but he knows he does not: he is consciously uncertain. On the other hand, he is unaware of something when he does not know it, and he does not know he does not know, and so on ad infinitum: he does not perceive, does not have in mind, the object of knowledge. The opposite of unawareness is awareness, which includes certainty and uncertainty. This paper has three main purposes. First, we formalize the concept of awareness, and introduce a symmetry axiom whic…