Search results for "proPO"
showing 10 items of 1325 documents
Melanoma epidemiology, prognosis and trends in Latvia
2012
Background Melanoma incidence and mortality rates are increasing worldwide within the white population. Clinical and histological factors have been usually used for the prognosis and assessment of the risk for melanoma. Objectives The aim of the study was to describe the clinical and histopathological features of the cutaneous melanoma (CM) in the Latvian population, to test the association between melanoma features and patient survival, and to assess the time trends for melanoma incidence. Methods We undertook a descriptive, retrospective analysis of archive data of 984 melanoma patients treated at the largest oncological hospital of Latvia, Riga East University Hospital Latvian Oncology C…
Supportive Efficacy Analyses for the Phase 3 Study of Temsirolimus Versus Investigator’s Choice Therapy for the Treatment of Patients with Relapsed o…
2008
Abstract Temsirolimus (Torisel®) is a specific inhibitor of the mTOR kinase with antitumor activity in patients with relapsed or refractory mantle cell lymphoma. In a phase 3, randomized, open-label study, patients treated with temsirolimus 175 mg weekly 3 times followed by 75 mg weekly (175/75-mg) had significantly longer progression-free survival (PFS) than those treated with investigator’s choice therapy (p-value temsirolimus: investigator’s choice = 0.0009; hazard ratio = 0.44; 97.5% CI = 0.25, 0.78; Hess et al. J Clin Oncol.2008, 28:abs 8513). Patients treated with temsirolimus 175 mg weekly 3 times followed by 25 mg weekly (175/25-mg) showed a trend towards longer PFS than those treat…
Chiral bis(amino alcohol)oxalamides as ligands for asymmetric catalysis. Ti(IV) catalyzed enantioselective addition of diethylzinc to aldehydes
2005
Abstract Several chiral bis(aminoalcohol)oxalamides with C 2 -symmetry have been prepared and used as ligands for the enantioselective addition of diethylzinc to aromatic and aliphatic aldehydes. The reaction proceeds in the presence of titanium isopropoxide to give the corresponding ( S )-alcohols with ee up to 78%. In the absence of Ti(IV), the alcohols with the opposite configuration are obtained.
Has pharmaceutical research become more scientific?
1996
Pharmaceutical research continues to be highly empirical, despite some recent writings arguing that it has become more scientific. Contrary to a study asserting that Mevacor, Tagamet, and Capoten demonstrate the success of targeted research, these drugs were discovered only after many years of following leads. Two hypotheses implied by the proposition that pharmaceutical research has become more scientific are tested. The first hypothesis is that the uncertainty of research has fallen. The second is that the number of publications by scientists in the industry has increased. Both are rejected.
Que proposent les conseils de classe en 1987 ?
1987
International audience
L'AMBITO FAMIGLIARE
2011
Il capitolo si prefigge di analizzare i processi di abbandono dei modelli di famiglia "tradizionale" ed analizza le principali trasformazioni del concetto di famiglia nei paesi occidentali. La parte empirica è rivolta all'analisi della discriminazione delle persone trans nelle loro famiglie di appartenenza e allo studio delle famiglie con figli omosessuali relativamente al processo di coming out.
Next Generation Search for Axion and ALP Dark Matter with the International Axion Observatory
2018
International audience; More than 80 years after the postulation of dark matter, its nature remains one of the fundamental questions in cosmology. Axions are currently one of the leading candidates for the hypothetical, non-baryonic dark matter that is expected to account for about 25% of the energy density of the Universe. Especially in the light of the Large Hadron Collider at CERN slowly closing in on Weakly-Interacting Massive Particle (WIMP) searches, axions and axion-like particles (ALPs) provide a viable alternative approach to solving the dark matter problem. The fact that makes them particularly appealing is that they were initially introduced to solve a long-standing problem in qu…
Prognostic Influence of Pre-Operative C-Reactive Protein in Node-Negative Breast Cancer Patients
2014
The importance of inflammation is increasingly noticed in cancer. The aim of this study was to analyze the prognostic influence of pre-operative serum C-reactive protein (CRP) in a cohort of 148 lymph node-negative breast cancer patients. The prognostic significance of CRP level for disease-free survival (DFS), metastasis-free survival (MFS) and overall survival (OS) was evaluated using univariate and multivariate Cox regression, also including information on age at diagnosis, tumor size, tumor grade, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) status, proliferation index (Ki67) and molecular subtype, as well as an assessment of the…
Immunohistochemical Detection of Hormone Receptors in Breast Carcinomas (ER-ICA, PgR-ICA): Prognostic Usefulness and Comparison with the Biochemical …
1994
In a prospective study conducted since 1983, the hormone-receptor status of primary breast carcinomas was investigated using immunohistochemical (ER-ICA, PgR-ICA) and biochemical (DCC) methods. The degree of immunohistochemical staining was evaluated according to the immunoreactive score (IRS) devised by Remmele and Stegner [Frauenarzt 28, 41-43 (1987)]. The findings obtained using the biochemical radioactive-ligand-binding assay (cutoff level, 20 fmol/mg) and those obtained using qualitative immunohistochemical methods were in agreement in 72.5% (ER-ICA) and 72.2% (PgR-ICA) of cases. For the 789 cases of primary breast carcinoma examined, postoperative data were available for a mean follow…
Proporcionālās spriešanas attīstīšana pamatskolas matemātikas kursā
2022
Pētījums balstīts uz nepieciešamību mērķtiecīgi attīstīt skolēnu proporcionālo spriešanu kā domāšanas stratēģiju, lai uzlabotu izpratni par matemātikas mācību saturu, sniedzot ieteikumus pedagogiem, kā virzīt mācīšanos, lai katrs skolēns pilnveidotu savas spriešanas prasmes. Pētījuma mērķis ir analizēt proporcionālās spriešanas attīstības pēctecību matemātikas mācību programmā 5. – 9. klasei un aprobēt mācību materiālus proporcionālās spriešanas mērķtiecīgai attīstīšanai 6. klasē, sniedzot metodiskos ieteikumus skolēnu domāšanas stratēģiju pilnveidei. Šī pētījuma rezultātā ir apkopoti temati un aktivitātes no matemātikas mācību programmas, lai plānotu ilgtermiņa proporcionālās spriešanas at…