Search results for "problems"
showing 10 items of 620 documents
Cultural institutions as agents of urban and community regeneration in the (post-)pandemic city. The case of the «Laboratorio Zen Insieme» in Palermo
2022
Although all cities in the world have been affected by the COVID-19 pandemic, its impacts on the territories, yet to be understood, are unevenly distributed, revealing extremely varied imbalances depending on the places. However, it is clear that the virus and its variants have aggravated pre-existing socio-spatial inequalities, creating new ones and bringing attention back to those implications between space, planning, public health and citizenship that are at the origins of contemporary urbanism. In a reference framework in which the crisis is globalized but unequal and in the absence of a welfare system capable of responding to the urgencies of the most marginalized social contexts and g…
Genetic determinants of ototoxicity during and after childhood cancer treatment: Protocol for the pancarelife study
2019
BACKGROUND: Survival rates after childhood cancer now reach nearly 80% in developed countries. However, treatments that lead to survival and cure can cause serious adverse effects with lifelong negative impacts on survivor quality of life. Hearing impairment is a common adverse effect in children treated with cisplatin-based chemotherapy or cranial radiotherapy. Ototoxicity can extend from high-tone hearing impairment to involvement of speech frequencies. Hearing impairment can impede speech and language and neurocognitive development. Although treatment-related risk factors for hearing loss following childhood cancer treatment have been identified, the individual variability in toxicity of…
Association of candidate pharmacogenetic markers with platinum-induced ototoxicity
2020
Genetic association studies suggest a genetic predisposition for cisplatin-induced ototoxicity. Among other candidate genes, thiopurine methyltransferase (TPMT) is considered a critical gene for susceptibility to cisplatin-induced hearing loss in a pharmacogenetic guideline. The PanCareLIFE cross-sectional cohort study evaluated the genetic associations in a large pan-European population and assessed the diagnostic accuracy of the genetic markers. 1,112 pediatric cancer survivors who had provided biomaterial for genotyping were screened for participation in the pharmacogenetic association study. 900 participants qualified for inclusion. Based on the assessment of original audiograms, patien…
Optimization Problems via Best Proximity Point Analysis
2014
1 Department of Mathematics, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia 2Department of Mathematics, Atilim University, Incek, 06836 Ankara, Turkey 3 Department of Mathematics, Babes-Bolyai University, Kogalniceanu Street No. 1, 400084 Cluj-Napoca, Romania 4Universita Degli Studi di Palermo, Dipartimento di Matematica e Informatica, Via Archirafi 34, 90123 Palermo, Italy
Guaranteed lower bounds for cost functionals of time-periodic parabolic optimization problems
2019
In this paper, a new technique is shown for deriving computable, guaranteed lower bounds of functional type (minorants) for two different cost functionals subject to a parabolic time-periodic boundary value problem. Together with previous results on upper bounds (majorants) for one of the cost functionals, both minorants and majorants lead to two-sided estimates of functional type for the optimal control problem. Both upper and lower bounds are derived for the second new cost functional subject to the same parabolic PDE-constraints, but where the target is a desired gradient. The time-periodic optimal control problems are discretized by the multiharmonic finite element method leading to lar…
Greedy and K-Greedy algoritmhs for multidimensional data association
2011
[EN] The multidimensional assignment (MDA) problem is a combinatorial optimization problem arising in many applications, for instance multitarget tracking (MTT). The objective of an MDA problem of dimension $d\in\Bbb{N}$ is to match groups of $d$ objects in such a way that each measurement is associated with at most one track and each track is associated with at most one measurement from each list, optimizing a certain objective function. It is well known that the MDA problem is NP-hard for $d\geq3$. In this paper five new polynomial time heuristics to solve the MDA problem arising in MTT are presented. They are all based on the semi-greedy approach introduced in earlier research. Experimen…
Short term association between ozone and mortality: global two stage time series study in 406 locations in 20 countries
2020
Objective To assess short term mortality risks and excess mortality associated with exposure to ozone in several cities worldwide. Design Two stage time series analysis. Setting 406 cities in 20 countries, with overlapping periods between 1985 and 2015, collected from the database of Multi-City Multi-Country Collaborative Research Network. Population Deaths for all causes or for external causes only registered in each city within the study period. Main outcome measures Daily total mortality (all or non-external causes only). Results A total of 45 165 171 deaths were analysed in the 406 cities. On average, a 10 µg/m3 increase in ozone during the current and previous day was associated with a…
Short term associations of ambient nitrogen dioxide with daily total, cardiovascular, and respiratory mortality: multilocation analysis in 398 cities
2021
Objective To evaluate the short term associations between nitrogen dioxide (NO2) and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide, using a uniform analytical protocol. Design Two stage, time series approach, with overdispersed generalised linear models and multilevel meta-analysis. Setting 398 cities in 22 low to high income countries/regions. Main outcome measures Daily deaths from total (62.8 million), cardiovascular (19.7 million), and respiratory (5.5 million) causes between 1973 and 2018. Results On average, a 10 μg/m3 increase in NO2 concentration on lag 1 day (previous day) was associated with 0.46% (95% confidence interval 0.36% to 0.5…
Detachment From Parents, Problem Behaviors, and the Moderating Role of Parental Support Among Italian Adolescents
2012
This study examined the relationship of emotional detachment from parents, parental support, and problem behaviors and focused on the unique and common contribution that detachment and parental support made to internalizing and externalizing behavioral problems. A total of 461 young adolescents, 13 to 14 years old ( M = 13.4; SD = 0.44), 234 boys and 227 girls, completed self-reporting measures of detachment, parental support, and internalizing and externalizing problems. Data showed that detachment was related positively to internalizing problem behaviors. Results revealed that parental support played a moderating role in the relationship between detachment and internalizing problems, suc…
Higher aggression is related to poorer academic performance in compulsory education
2019
Background To conduct a comprehensive assessment of the association between aggression and academic performance in compulsory education. Method We studied aggression and academic performance in over 27,000 individuals from four European twin cohorts participating in the ACTION consortium (Aggression in Children: Unraveling gene‐environment interplay to inform Treatment and InterventiON strategies). Individual level data on aggression at ages 7–16 were assessed by three instruments (Achenbach System of Empirically Based Assessment, Multidimensional Peer Nomination Inventory, Strengths and Difficulties Questionnaire) including parental, teacher and self‐reports. Academic performance was measu…