Search results for "programme"

IAP proteins as targets for drug development in oncology.

2013

The inhibitors of apoptosis (IAPs) constitute a family of proteins involved in the regulation of various cellular processes, including cell death, immune and inflammatory responses, cell proliferation, cell differentiation, and cell motility. There is accumulating evidence supporting IAP-targeting in tumors: IAPs regulate various cellular processes that contribute to tumor development, such as cell death, cell proliferation, and cell migration; their expression is increased in a number of human tumor samples, and IAP overexpression has been correlated with tumor growth, and poor prognosis or low response to treatment; and IAP expression can be rapidly induced in response to chemotherapy or …

Mechanisms of cell death in canine parvovirus-infected cells provide intuitive insights to developing nanotools for medicine

2010

Jonna Nykky, Jenni E Tuusa, Sanna Kirjavainen, Matti Vuento, Leona GilbertNanoscience Center and Department of Biological and Environmental Science, University of Jyväskylä, FinlandAbstract: Viruses have great potential as nanotools in medicine for gene transfer, targeted gene delivery, and oncolytic cancer virotherapy. Here we have studied cell death mechanisms of canine parvovirus (CPV) to increase the knowledge on the CPV life cycle in order to facilitate the development of better parvovirus vectors. Morphological studies of CPV-infected Norden laboratory feline kidney (NLFK) cells and canine fibroma cells (A72) displayed characteristic apoptotic events. Apoptosis was f…

The Major Heat Shock Proteins, Hsp70 and Hsp90, in 2-Methoxyestradiol-Mediated Osteosarcoma Cell Death Model

2020

2-Methoxyestradiol is one of the natural 17&beta

Opettaja television opetusohjelman käyttäjänä : tapaustutkimus ohjelmien käytöstä 6. luokkien historian löytöretkijaksolla

1997

Lessons learned from Creation of Digitally Competent Educators SLP

2021

[Introduction] Mismatch of competences and socio-economical results of this issue is recognized as an important problem for higher education institutes (HEIs) in Europe. To cope with this issue HEIs need to create new more flexible and modular structures. In this context, a European HEIs are encouraged to create micro-credentials and short learning programmes (Futures et al., 2020). European Short Learning Programmes (E-SLPs) are one of these new and flexible structures suggested by an EU Project funded under Erasmus+ Programme, Key Action 3: Support for Policy Reform, Initiatives for Policy Innovation, "Forward Looking Cooperation Projects". SLPs have potential to respond to market needs a…

Analysing students’rating of the SLP Digitally Competent Educators

2021

This article uses student feedback to examine the perspective of participants in the short learning programme (SLP) pilot Digitally Competent Educators (DCE). This SLP was targeted at the continuous professional development and lifelong learning for educators at various levels and several education areas. Student feedback was collected in 2020 using anonymous surveys at the end of each course. This implies that respondents were those participants who completed the course. Feedback, used on further development of the SLP, focused on the content and implementation of the course modules. The SLP followed the design guidelines produced inside the E-SLP project and was based on the Digital Compe…

Apollon gene silencing induces apoptosis in breast cancer cells via p53 stabilisation and caspase-3 activation

2009

We analysed the effects of small interfering RNA (siRNA)-mediated silencing of Apollon, a member of the inhibitors of apoptosis protein family, on the proliferative potential and ability of human breast cancer cell lines to undergo apoptosis. In wild-type p53 ZR75.1 cells, Apollon knockdown resulted in a marked, time-dependent decline of cell growth and an increased rate of apoptosis, which was associated with p53 stabilisation and activation of the mitochondrial-dependent apoptotic pathway. Pre-incubation of cells with a p53-specific siRNA resulted in a partial rescue of cell growth inhibition, as well as in a marked reduction of the apoptotic response, indicating p53 as a major player in …

Molecular mechanisms of MYCN-dependent apoptosis and the MDM2-p53 pathway: an Achille’s heel to be exploited for the therapy of MYCN amplified neurob…

2012

The p53 oncosuppressor is very seldom mutated in neuroblastoma, but several mecha- nisms cooperate to its functional inactivation in this tumor. Increased MDM2 levels, due to genetic amplification or constitutive inhibition of p14ARF, significantly contribute to this event highlighting p53 reactivation as an attractive perspective for neuroblastoma treat- ment. In addition to its role in tumorigenesis, MYCN sensitizes untransformed and cancer cells to apoptosis. This is associated to a fine modulation of the MDM2-p53 pathway Indeed MYCN induces p53 and MDM2 transcription, and, by evoking a DNA damage response (DDR), it stabilizes p53 and its proapoptotic kinase Homeodomain Interacting Prote…

Video programmes as learning tools : teaching the gas laws and behaviour of gases in Finnish and Canadian senior high schools

2003

La médiatisation du culinaire

2010

coordination du dossier : Jean-Jacques Boutaud et Véronique Madelon; International audience; Ce dossier se penche sur la rencontre entre l'univers des médias et celui du culinaire. Qu'est-ce qui justifie cette rencontre ? Le culinaire est à prendre dans le sens généralisant de ce qui a trait à la cuisine. Terme polysémique, la cuisine est tout à la fois rabattue sur un lieu, des pratiques, des aliments, des styles et des cultures. De sorte que si le goût, comme sensation à la fois élémentaire et complexe, relève de l'indicible et contrarie la communication, l'univers culinaire se prête à la multiplication des angles, des éclairages. Mais comment expliquer, alors que la littérature culinaire…