Search results for "programming."

The Use of Rule-Based and QSPR Approaches in ADME Profiling: A Case Study on Caco-2 Permeability.

2013

During the early ADME profiling the development of simple, interpretable and reliable in silico tools is very important. In this study, rule-based and QSPR approaches were investigated using a large Caco-2 permeability database. Three permeability classes were determined: high (H), moderate (M) and low (L). The main physicochemical properties related with permeability were ranked as follows: Polar Surface Area (PSA)>Lipophilicity (logP/logD)>Molecular Weight (MW)>number of Hydrogen Bond donors and acceptors>Ionization State>number of Rotatable Bonds>number of Rings. The best rule, based on the combination of PSA-MW-logD (3PRule), was able to identify the H, M and L classes with accuracy of …

Race course profiling of the cross country ski using kinematic GNSS

2018

An adaptive approach to learning the preferences of users in a social network using weak estimators

2012

Published version of an article in the journal: Journal of Information Processing Systems. Also available from the publisher at: http://dx.doi.org/10.3745/JIPS.2012.8.2.191 - Open Access Since a social network by definition is so diverse, the problem of estimating the preferences of its users is becoming increasingly essential for personalized applications, which range from service recommender systems to the targeted advertising of services. However, unlike traditional estimation problems where the underlying target distribution is stationary; estimating a user's interests typically involves non-stationary distributions. The consequent time varying nature of the distribution to be tracked i…

La gestión de la programación teatral en España

2007

El sector de las artes escénicas ha destacado en los últimos años por un gran dinamismo y crecimiento. La mayor oferta y demanda de estas actividades culturales ha puesto de manifiesto la necesidad de gestionar el diseño de la programación desde una perspectiva más profesional, al tiempo que investigar esta materia. Sin embargo, son todavía escasos los estudios de naturaleza académica al respecto. En este sentido, los autores han desarrollado un estudio empírico centrado en responsables de programación de entidades escénicas españolas. Si bien el criterio de programación más valorado ha sido el perfil de la audiencia, ello no parece implicar una total aplicación de los principios y técnicas…

And Now for Something Completely Different: Running Lisp on GPUs

2018

The internal parallelism of compute resources increases permanently, and graphics processing units (GPUs) and other accelerators have been gaining importance in many domains. Researchers from life science, bioinformatics or artificial intelligence, for example, use GPUs to accelerate their computations. However, languages typically used in some of these disciplines often do not benefit from the technical developments because they cannot be executed natively on GPUs. Instead existing programs must be rewritten in other, less dynamic programming languages. On the other hand, the gap in programming features between accelerators and common CPUs shrinks permanently. Since accelerators are becomi…

DEXML: A First Step Toward a UML Based Implementation Framework for PLCS

2011

Data exchange specifications not only must be broad and general to achieve acceptance, but also must be customizable in a controlled and interoperable manner to be useful. The Product Life Cycle Support (PLCS) suite of data exchange specifications (known as DEXs) uses templates to enable controlled customizability without sacrificing breadth or interoperability. DEXs are business context-specific subsets of ISO 10303 Application Protocol (AP) 239, subject to additional constraints imposed by the templates. A PLCS template defines how AP239 entities and their attributes will be instantiated using an externally-defined controlled vocabulary defined in a Reference Data Library. Template instan…

XML Integration and Toolkit for B2B Applications

2003

This paper presents a Web-based data integration methodology and tool framework, called X-TIME, for the development of business-to-business (B2B) design environments and applications. X-TIME provides a data model translator toolkit based on an extensible metamodel and XML. It allows the creation of adaptable semantics oriented metamodels to facilitate the design of wrappers or reconciliators (mediators) by taking into account several characteristics of interoperable information systems such as extensibility and composability. X-TIME defines a set of meta-types for representing meta-level semantic descriptors of data models found in the Web. The meta-types are organized in a generalization h…

How to Bootstrap a Language Workbench

2019

From Requirements to Code in a Model Driven Way

2010

Though there is a lot of support for model driven development the support for complete model driven path from requirements to code is limited. The approach proposed in this paper offers such a path which is fully supported by model transformations. The starting point is semiformal requirements containing behaviour description in a controlled natural language. A chain of models is proposed including analysis, platform independent and platform specific models. A particular architecture style is chosen by means of selecting a set of appropriate design patterns for these models. It is shown how to define informally and then implement in model transformation language MOLA the required transforma…

Statechart-based design controllers for FPGA partial reconfiguration

2015

Statechart diagram and UML technique can be a vital part of early conceptual modeling. At the present time there is no much support in hardware design methodologies for reconfiguration features of reprogrammable devices. Authors try to bridge the gap between imprecise UML model and formal HDL description. The key concept in author's proposal is to describe the behavior of the digital controller by statechart diagrams and to map some parts of the behavior into reprogrammable logic by means of group of states which forms sequential automaton. The whole process is illustrated by the example with experimental results.