Search results for "progre"

Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters

2002

In the present study, we addressed the question of a putative relevance of Rho proteins in tumour progression by analysing their expression on protein and mRNA level in breast tumours. We show that the level of RhoA, RhoB, Rac1 and Cdc42 protein is largely enhanced in all tumour samples analysed (n=15) as compared to normal tissues originating from the same individual. The same is true for 32P-ADP-ribosylation of Rho proteins which is catalysed by Clostridium botulinum exoenzyme C3. Also the amount of Rho-GDI and ERK2 as well as the level of overall 32P-GTP binding acvitity was tumour-specific elevated, yet to a lower extent than Rho proteins. Although the amount of Rho proteins was enhance…

Associations between teacher quality, instructional quality and student reading outcomes in Nordic PIRLS 2016 data

2022

AbstractProgress in International Reading Literacy Study (PIRLS) focuses on the reading proficiency of students mostly in the fourth year of schooling. A wide selection of studies has shown that family background and early literacy activities at home have substantial associations with student achievement in reading literacy. However, research focusing on teacher qualities and teaching processes is inadequate. In this study, we focus on associations of teacher quality (formal qualifications and professional identity) and instructional quality (classroom management, cognitive activation and teacher support) with cognitive and affective-motivational student outcomes (variables Reading Achievem…

Rho GTPases: Promising Cellular Targets for Novel Anticancer Drugs

2006

Ras-homologous (Rho) GTPases play a pivotal role in the regulation of numerous cellular functions associated with malignant transformation and metastasis. Rho GTPases are localized at membranes and become activated upon stimulation of cell surface receptors. In their GTP-bound (=active) state, Rho proteins bind to effector proteins, thereby triggering specific cellular responses. Members of the Rho family of small GTPases are key regulators of actin reorganization, cell motility, cell-cell and cell-extracellular matrix (ECM) adhesion as well as of cell cycle progression, gene expression and apoptosis. Each of these functions is of importance for the development and progression of cancer. Fu…

Cypriana Norwida słowo i druk

2009

Sekundāri progresējoši noritošas multiplās sklerozes riska faktori izvērtējot slimības norises formas un pielietoto terapiju

2016

Ievads: Multiplā skleroze ir viena no biežāk sastopamajām hroniskām neirodeģeneratīvām saslimšanām, kas progresējot pacientam izraisa darba nespēju un būtiski ietekmē pacienta dzīves kvalitāti. Darba mērķis: ir noskaidrot invaliditātes attīstības straujumu pacientiem ar sekundāri progresējošu multiplo sklerozi, atkarībā no slimības progresēšanas, saslimšanas vecuma, slimības ilguma, dzimuma un terapijas. Metodes un materiāli: Retrospektīva pētījuma ietvaros tika skatītas pacientu ambulatorās kartiņas ar sekundāri progresējošu multiplo sklerozi Latvijas Jūras Medicīnas Centra Latvijas Multiplās sklerozes centrā. Kopumā tika apskatītas 80 pacientu ambulatorās kartiņas no saslimšanas brīža līd…

Le temps de l'expérimentation et l'expérience du temps chez Richard Pinhas

2014

International audience

Appraisals of education-related goals during educational transitions in late adolescence : consequences for academic well-being and goal attainment

2012

Voimaharjoittelun vaikutukset dynaamiseen ja staattiseen tasapainoon nuorilla ja ikääntyneillä

2017

Tasapainolle ei ole olemassa universaalia määritelmää mutta se tiedetään, että sitä kontrolloivat useat eri mekanismit. Ikääntyminen aiheuttaa siinä heikkenemistä, joka aiheutuu muutoksista sekä sensorisissa että motorisissa prosesseissa. Kaatumisesta aiheutuneiden vammojen määrä kasvaa koko ajan ikääntyneillä. Heidän onkin havaittu pärjäävän nuoria huonommin sekä staattisissa että dynaamisissa testeissä mutta dynaamisissa testeissä ero on vieläkin suurempi. Erityisesti dynaamisten ominaisuuksin tutkiminen on tärkeää sillä staattiset testit eivät välttämättä paljasta tasapaino-ongelmia tai ikääntymiseen liittyviä eroja yhtä hyvin kuin dynaamiset testit. Tämän tutkimuksen suoritti loppuun 4 …

Open-ended projects opened up — aspects of openness

2017

Abstract—One of the most important areas of competence for professional engineers is the ability to function well in project work, in particular they need to be able to efficiently solve open-ended problems in different collaborative settings. The development of this ability is however not prominent in engineering education despite numerous authors suggesting openended problems as a pedagogical tool to promote development of collaborative problem solving competence by including elements of group or project work in courses. In our own long experience of using open-ended problems in collaborative student projects, we have identified a lack of systematic progression in learning outcomes and sk…

Humanisierung des technischen Fortschritts. Ein Projekt von Papst Franziskus

2020

Theology of technique, in addition to the philosophy of technique, opens up a new research perspective on technique that defines everything or almost everything in the reality that surrounds us. The aim of these considerations my research is to seek a new idea of technological progress that will allow building of an integral vision of reality. The teaching of Pope Francis, especially in the Encyclical Laudato si’ (2015), forms the basis for the selected topic. The structure of the considerations refers to the principles of the social doctrine of the so-called three steps: look, judge, act. Therefore, the text presents firstly the features of technical progress (1), then its evaluation (2), …