Search results for "proof-of-concept"
showing 2 items of 2 documents
A phase 2 randomized, double-blind, placebo-controlled, proof-of-concept study of oral seletalisib in primary Sjögren’s syndrome
2020
Abstract Objectives This phase 2 proof-of-concept study (NCT02610543) assessed efficacy, safety and effects on salivary gland inflammation of seletalisib, a potent and selective PI3Kδ inhibitor, in patients with moderate-to-severe primary Sjögren’s syndrome (PSS). Methods Adults with PSS were randomized 1:1 to seletalisib 45 mg/day or placebo, in addition to current PSS therapy. Primary end points were safety and tolerability and change from baseline in EULAR Sjögren’s Syndrome Disease Activity Index (ESSDAI) score at week 12. Secondary end points included change from baseline at week 12 in EULAR Sjögren’s Syndrome Patient Reported Index (ESSPRI) score and histological features in salivary …
On Apache Log4j2 Exploitation in Aeronautical, Maritime, and Aerospace Communication
2022
Apache Log4j2 is a prevalent logging library for Java-based applications. In December 2021, several critical and high-impact software vulnerabilities, including CVE-2021-44228, were publicly disclosed, enabling remote code execution (RCE) and denial of service (DoS) attacks. To date, these vulnerabilities are considered critical and the consequences of their disclosure far-reaching. The vulnerabilities potentially affect a wide range of internet of things (IoT) devices, embedded devices, critical infrastructure (CI), and cyber-physical systems (CPSs). In this paper, we study the effects and feasibility of exploiting these vulnerabilities in mission-critical aviation and maritime environment…