Search results for "proportion"
showing 10 items of 877 documents
Il governo tecnocratico della moneta e i crocevia del processo di integrazione europea. Riflessioni alla luce della sentenza Weiss
2021
The well known judgment of the German Constitutional Court in the “Weiss” case has been widely criticized under EU law, mainly because of its being in contrast with a preliminary ruling rendered by the European Court of Justice in 2018. At variance with these criticisms, it is here submitted that such a judgment brings well into focus some institutional ambiguities of the Economic and Monetary Union (EMU); namely, the powers (more and more) exercised by the European Central Bank (ECB) in the field of macroeconomic regulation and control, in spite of (its) not being provided with political legitimacy. Seen in this perspective, the “Karlsruhe” judgment objectively looks as aimed at restoring …
The Protection of the Right of Freedom on the European Union Level: The European Arrest Warrant and Non-custodial Pre Trial Measures. The Guideline o…
2013
"Protection of fundamental rights in particular must be central to the operation of the system": la formula, adoperata al culmine del più recente documento valutativo sull’esperienza del MAE (2011), ben sintetizza, sul piano dell'indirizzo politico, il progressivo spostamento degli accenti logici, dalla prospettiva dell'efficienza e della sicurezza a quella della primazia della tutela dei diritti individuali, dell'intero quadrante delle misure limitative della libertà individuale in ambito UE. I vissuti del principio di proporzionalità divengono, per questa via, paradigmi di fondo per la lettura del sistema in termini di applied law: i tre livelli attraverso i quali il filtro di proporziona…
Proporzionalità, diritti, democrazia
2014
Il principio di proporzionalità è ormai uno dei concetti centrali del costituzionalismo globale, di fatto una parte essenziale della grammatica di una nuova lingua franca che fa dialogare e interagire attori giuridici sostanzialmente in tutto il mondo, agevolando la circolazione di modelli giuridici e di standard di argomentazione. In questo saggio intendo discutere due questioni attinenti al profilo della legittimità dell’utilizzazione del test di proporzionalità in sede giudiziaria. La prima questione riguarda la compatibilità tra l’utilizzo sempre più diffuso del test di proporzionalità e l’intensità della tutela che ci aspettiamo debbano ricevere i diritti fondamentali. La seconda quest…
Diritti fondamentali e principio di proporzionalità
2014
the paper assesses the widespread use of the test of proportionality in fundamental rights adjudication. While constitutional and human rights courts all over the world appear to be consistently engaged in deploying the test of proportionality in order to assess the permissibility of a given rights limitation, this approach is under severe criticism insofar as it is considered an attack to the very idea of fundamental rights. The paper will discuss this criticism of the use of proportionality, and will provide a defense of its use by courts in light of some basic features of the contemporary discourse of fundamental rights.
Prognostic significance of p16INK4a alterations and 9p21 loss of heterozigosity in locally advanced laryngeal squamous cell carcinoma
2002
The p16INK4a gene, localized within chromosome 9p21, has been identified as a cyclin-dependent kinase inhibitor and may negatively regulate the cell cycle acting as a tumor suppressor. Genetic alterations involving the 9p21 region are common in human cancers. A consecutive series of 64 untreated patients (median of follow up 53 months) undergoing surgical resection for locally advanced laryngeal squamous-cell carcinomas (LSCCs) has been studied prospectively. Our purpose was to investigate p16 alterations (9p21 allelic loss, hypermethylation and point mutations) and their possible association with clinico-pathological data and flow cytometric variables (DNA-ploidy and S-phase fraction (SPF)…
The association of uric acid with mortality modifies at old age: data from the uric acid right for heart health (URRAH) study
2021
Objectives: In older individuals, the role of serum uric acid (SUA) as risk factor for mortality is debated. This study investigated the association of SUA with all-cause and cardiovascular (CV) mortality in older adults participating in the large multicentre observational uric acid right for heart health (URRAH) study. Methods: Eight thousand URRAH participants aged 65+ were included in the analysis. The predictive role of SUA was assessed using Cox regression models stratified according to the cut-off age of 75. SUA was tested as continuous and categorical variable (age-specific quartiles). The prognostic threshold of SUA for mortality was analysed using receiver operating characteristic …
A Proposal to estimate the roaming–dog Total in an urban area through a PPSWOR spatial sampling with sample size greater than two
2018
What keeps young adults in permanent poverty? A comparative analysis using ECHP
2009
Abstract Previous studies suggest that there are strong differences in the rates of youth poverty across European countries. Rather surprisingly, it is found to be high in Scandinavian countries, and relatively speaking, lower in Mediterranean and Anglo-Saxon countries. This somewhat unexpected finding prompts the question whether the incidence of poverty is an appropriate measure of youth disadvantage. Instead of considering poverty rates we consider the length of recorded poverty spells, taking into account explicitly the temporal sequencing of the episodes of poverty. Using the European Community Household Panel, individuals are classified into different groups of poverty permanence, eac…
Sorafenib in advanced hepatocellular carcinoma
2008
none 25 BACKGROUND: No effective systemic therapy exists for patients with advanced hepatocellular carcinoma. A preliminary study suggested that sorafenib, an oral multikinase inhibitor of the vascular endothelial growth factor receptor, the platelet-derived growth factor receptor, and Raf may be effective in hepatocellular carcinoma. METHODS: In this multicenter, phase 3, double-blind, placebo-controlled trial, we randomly assigned 602 patients with advanced hepatocellular carcinoma who had not received previous systemic treatment to receive either sorafenib (at a dose of 400 mg twice daily) or placebo. Primary outcomes were overall survival and the time to symptomatic progression. Seconda…
Survival analysis of proposed BCLC-B subgroups in hepatocellular carcinoma patients
2013
Background & Aims The BCLC-staging system is used to facilitate treatment decisions in patients with hepatocellular carcinoma (HCC). Owing to the observed clinical heterogeneity of the intermediate stage BCLC-B, a subclassification was proposed taking Child–Pugh score and extended criteria for transplantation into account. Analysis of the prognostic significance of a proposed subclassification of the BCLC-B score in a European cohort of HCC patients. Methods Eight hundred and eighty four consecutive HCC patients were retrospectively analysed. Patients with stage BCLC-B were grouped according to the proposed subclassification. Baseline patient and tumour characteristics, therapy and overall …