Search results for "proteine"

Long-term efficacy of lipoprotein apheresis and lomitapide in the treatment of homozygous familial hypercholesterolemia (HoFH): a cross-national retr…

2021

Abstract Background Homozygous familial hypercholesterolemia (HoFH) is a rare life-threatening condition that represents a therapeutic challenge. The vast majority of HoFH patients fail to achieve LDL-C targets when treated with the standard protocol, which associates maximally tolerated dose of lipid-lowering medications with lipoprotein apheresis (LA). Lomitapide is an emerging therapy in HoFH, but its place in the treatment algorithm is disputed because a comparison of its long-term efficacy versus LA in reducing LDL-C burden is not available. We assessed changes in long-term LDL-C burden and goals achievement in two independent HoFH patients’ cohorts, one treated with lomitapide in Ita…

Addition of NMDA-receptor antagonist MK801 during oxygen/glucose deprivation moderately attenuates the upregulation of glucose uptake after subsequen…

2011

During stroke the blood–brain barrier (BBB) is damaged which can result in vasogenic brain edema and inflammation. The reduced blood supply leads to decreased delivery of oxygen and glucose to affected areas of the brain. Oxygen and glucose deprivation (OGD) can cause upregulation of glucose uptake of brain endothelial cells. In this letter, we investigated the influence of MK801, a non-competitive inhibitor of the NMDA-receptor, on the regulation of the glucose uptake and of the main glucose transporters glut1 and sglt1 in murine BBB cell line cerebEND during OGD. mRNA expression of glut1 was upregulated 68.7- fold after 6 h OGD, which was significantly reduced by 10 μM MK801 to 28.9-fold.…

A targeted apoB38.9 mutation in mice is associated with reduced hepatic cholesterol synthesis and enhanced lipid peroxidation.

2006

Familial hypobetalipoproteinemia (FHBL) due to truncation-specifying mutations of apolipoprotein B (apoB), which impair hepatic lipid export in very low-density lipoprotein (VLDL) particles, is associated with fatty liver. In an FHBL-like mouse with the apoB38.9 mutation, fatty liver develops despite reduced hepatic fatty acid synthesis. However, hepatic cholesterol contents in apoB38.9 mice are normal. We found that cholesterogenic enzymes (3-hydroxy-3-methylglutaryl-coenzyme A reductase, sterol-C5-desaturase, and 7-dehydrocholesterol reductase) were consistently downregulated in two separate expression-profiling experiments using a total of 19 mice ( n = 7 each for apob+/+and apob+/38.9, …

Insulin resistance and familial dyslipidaemias

1999

Metodo per la purificazione da sistemi di produzione batterici di proteine ricombinanti attive

2009

Un metodo per la produzione e purificazione da sistemi di produzione batterici di proteine ricombinanti attive con pre-sequenza di sei istidine.

L'accumulation des protéines dans les graines de légumineuses

2017

The agroecological benefits of legumes and the renewed interest in the consumption of vegetable proteins stimulate researches on cognitive and applied aspects of seed biology aiming at optimizing protein composition of legume seeds. This article presents the state of knowledge on the genetic and environmental control of the accumulation of major proteins found in legume seeds, with a view to developing varieties with improved nutritional seed quality. It also shows how high-throughput genomics and post-genomics data, along with translational research aiming at transferring knowledge between model and crop species, can accelerate the identification of genes controlling the accumulation of st…

Una nuova mutazione di splicing del gene dell’ApoB responsabile di Ipobetalipoproteinemia Familiare in una paziente con steatosi epatica

2011

Effetti “beyond-cholesterol” delle statine: la terapia con simvastatina riduce le lipoproteine aterogene in pazienti con coronaropatia prematura

2002

Internalization of novel non-viral vector TAT-streptavidin into human cells

2007

BMC Biotechnology, 7 (1)