Search results for "quantitative method"
showing 10 items of 170 documents
A mathematical model for the therapy of the HIV infection
2005
In this paper we consider the evolution of the HIV infection under a highly effective treatment based on a combination of RTI and/or PI drugs. This is usually modelled with a set of ODEs where the drug efficacy is a constant. In this paper we consider the treatment efficacy as a dynamic variable which evolves during the treatment. To model the dynamics of the drug efficacy we use an evolutive type assumption. The resulting set of ODEs are able to reproduce the typical pattern of the illness evolution under treatment: a period of remission, which can last several years, followed by a progressive recrudescence and a viral rebound.
Insights into genome plasticity of the wine-making bacterium Oenococcus oeni strain ATCC BAA-1163 by decryption of its whole genome.
2008
International audience; Studying genomes of O. oeni strains having opposite oenological aptitudes is important for understanding why this lactic acid bacterium involved in malolactic fermentation is so well adapted to wine. Here, the genome of a strain ATCC BAA-1163, is described and compared with the recently reported genome of the better wine-adapted strain PSU-1. The BAA-1163 genome (8X) was obtained by shotgun sequencing and Phrap assembling. Compact and 62% AT-rich, it consists of a circular 1,792,103-bp chromosome and a 3,948-bp plasmid. It was analysed through a CAAT-Box annotation platform and manually inspected. A total of 51 RNA genes were detected, including two rRNA operons (the…
Probability and algorithmics: a focus on some recent developments
2017
Jean-François Coeurjolly, Adeline Leclercq-Samson Eds.; International audience; This article presents different recent theoretical results illustrating the interactions between probability and algorithmics. These contributions deal with various topics: cellular automata and calculability, variable length Markov chains and persistent random walks, perfect sampling via coupling from the past. All of them involve discrete dynamics on complex random structures.; Cet article présente différents résultats récents de nature théorique illustrant les interactions entre probabilités et algorithmique. Ces contributions traitent de sujets variés : automates cellulaires et calculabilité, chaînes de Mark…
Approche préventive de la qualité des données d'importation dans le contexte de la protéomique clinique
2011
International audience; Dans le domaine biomédical, la protéomique est confrontée à des sources de données de plus en plus nombreuses et à des volumes de données très importants du fait de la multiplication des technologies dites à haut débit. L'hétérogénéité de la provenance des données implique de fait une hétérogénéité dans la représentation et le contenu de ces données. Les données peuvent aussi se révéler incorrectes ce qui engendre des erreurs sur les conclusions des expériences protéomiques. Notre approche a pour objectif de garantir la qualité initiale des données lors de leur importation dans un système d'information dédié à la protéomique. Elle est basée sur le couplage entre des …
Congenital anomalies from a physics perspective. The key role of "manufacturing" volatility
2020
Genetic and environmental factors are traditionally seen as the sole causes of congenital anomalies. In this paper we introduce a third possible cause, namely random "manufacturing" discrepancies with respect to ``design'' values. A clear way to demonstrate the existence of this component is to ``shut'' the two others and to see whether or not there is remaining variability. Perfect clones raised under well controlled laboratory conditions fulfill the conditions for such a test. Carried out for four different species, the test reveals a variability remainder of the order of 10%-20% in terms of coefficient of variation. As an example, the CV of the volume of E.coli bacteria immediately after…
L'annuaire des Centres de Ressources Biologiques français
2011
International audience
The I3-CRB project and the French biological ressources centers
2010
International audience
The spatial analysis of cemeteries revisited. The example of the Late Iron Age and Early Gallo-Roman cemetery of Lamadelaine (Grand Duchy of Luxembou…
2012
Gräberfelder zeigen selten zufällig angelegte und verteilte Grabstrukturen. Die Gräber selbst entstehen normalerweise in einem spontanen Prozess; in ihnen werden meist vollständig erhaltene Grabbeigaben absichtlich deponiert. Aus diesem Grund eignet sich diese Gattung archäologischer Befunde gut für eine quantitative und räumliche Analyse, die erlaubt, Informationen über die räumliche Organisation, den zeitlichen Ablauf und über sozio-ökonomische Aspekte des Friedhofes zu erhalten. Dieser Artikel bewertet die wichtigsten Methoden der räumlichen Analyse eines Fundplatzes, angepasst an Gräberfelder, auf Basis der vorgeschichtlichen und römischen Nekropole von Lamadelaine; weiter hin liefert e…
Matrices de pondérations et contexte spatio-temporel en économétrie spatiale
2013
International audience
Climate and agriculture: empirical evidence for countries and agroecological zones of the Sahel
2022
International audience; ow heterogenous is the impact of climate change across space and the type of agricultural production? In this paper, we investigate the relationship between climate change and variability, measured by temperature and rainfall, and agricultural production at the country and agroecological zone levels of the Sahel. We consider a crop production index and five cereals (maize, millet, sorghum, wheat and rice). Based on an original climate database and an agricultural production function estimated for the period 1961–2016, we show that average rainfall and temperature during the growing season indeed have highly heterogeneous effects on agricultural production, depending …