Search results for "quantitative"
showing 10 items of 2409 documents
Expression of calpain-calpastatin system (CCS) member proteins in human lymphocytes of young and elderly individuals; pilot baseline data for the CAL…
2013
Abstract Background Ubiquitous system of regulatory, calcium-dependent, cytoplasmic proteases – calpains – and their endogenous inhibitor – calpastatin – is implicated in the proteolytic regulation of activation, proliferation, and apoptosis of many cell types. However, it has not been thoroughly studied in resting and activated human lymphocytes yet, especially in relation to the subjects’ ageing process. The CALPACENT project is an international (Polish-Italian) project aiming at verifying the hypothesis of the role of calpains in the function of peripheral blood immune cells of Polish (Pomeranian) and Italian (Sicilian) centenarians, apparently relatively preserved in comparison to the g…
Fiscal Policy and Asset Price Cycles: Evidence from Four European Countries
2014
OS; International audience; We test for non-linear effects of asset prices on the fiscal policy of four major European economies (France, Italy, Spain and UK). We model government spending and revenue as time-varying transition probability Markovian processes (TVPMS), and find that: (i) in France and Italy, the impact of housing prices on government revenue is conditioned by the phase of the stock price cycle; (ii) a similar asymmetric pattern is found for the UK when considering the effect of stock price fluctuations on government revenue and spending vis-à-vis the troughs and peaks of aggregate wealth; and (iii) for Spain, a fall in government revenue is typically associated with a negati…
Methods of research Textual analysis
2014
Can evolution of sexual dimorphism be triggered by developmental temperatures?
2012
Genetic prerequisites for the evolution of sexual dimorphism, sex-specific heritabilities and low or negative genetic correlations between homologous traits in males and females are rarely found. However, sexual dimorphism is evolving rapidly following environmental change, suggesting that sexual dimorphism and its genetic background could be environmentally sensitive. Yet few studies have explored the sensitivity of the genetic background of sexual dimorphism on environmental variation. In this study, on Drosophila melanogaster, we used a large nested full-sib–half-sib breeding design where families were split into four different developmental temperatures: two constant temperature treatme…
Discovery of novel trichomonacidals using LDA-driven QSAR models and bond-based bilinear indices as molecular descriptors
2008
Few years ago, the World Health Organization estimated the number of adults with trichomoniasis at 170 million worldwide, more than the combined numbers for gonorrhea, syphilis, and chlamydia. To combat this sexually transmitted disease, Metronidazole (MTZ) has emerged, since 1959, as a powerful drug for the systematic treatment of infected patients. However, increasing resistance to MTZ, adverse effects associated to high-dose MTZ therapies and very expensive conventional technologies related to the development of new trichomonacidals necessitate novel computational methods that shorten the drug discovery pipeline. Therefore, bond-based bilinear indices, new 2-D bond-based TOMOCOMD-CARDD M…
Information – theoretic characterization of concurrent activity of neural spike trains
2021
The analysis of massively parallel spike train recordings facilitates investigation of communications and synchronization in neural networks. In this work we develop and evaluate a measure of concurrent neural activity, which is based on intrinsic firing properties of the recorded neural units. An overall single neuron activity is unfolded in time and decomposed into working and non-firing state, providing a coarse, binary representation of the neurons functional state. We propose a modified measure of mutual information to reflect the degree of simultaneous activation and concurrency in neural firing patterns. The measure is shown to be sensitive to both correlations and anti-correlations,…
Dependence of 85Kr(β)-Clearance rCBF Determination on the Input Function
1969
Two procedures have been proposed for the quantitative determination of rCBF by analysis of radioactive inert gas clearance curves, following intra-arterial injection: 1. the slope-method [1], 2. the height-over-area-method [4].
A proof of bistability for the dual futile cycle
2014
Abstract The multiple futile cycle is an important building block in networks of chemical reactions arising in molecular biology. A typical process which it describes is the addition of n phosphate groups to a protein. It can be modelled by a system of ordinary differential equations depending on parameters. The special case n = 2 is called the dual futile cycle. The main result of this paper is a proof that there are parameter values for which the system of ODE describing the dual futile cycle has two distinct stable stationary solutions. The proof is based on bifurcation theory and geometric singular perturbation theory. An important entity built of three coupled multiple futile cycles is…
Identification of clusters of investors from their real trading activity in a financial market
2012
We use statistically validated networks, a recently introduced method to validate links in a bipartite system, to identify clusters of investors trading in a financial market. Specifically, we investigate a special database allowing to track the trading activity of individual investors of the stock Nokia. We find that many statistically detected clusters of investors show a very high degree of synchronization in the time when they decide to trade and in the trading action taken. We investigate the composition of these clusters and we find that several of them show an over-expression of specific categories of investors.
Higher Education from a Longitudinal and Life Course Perspective
2015
International audience; This symposium brings together scholars from across Canada, Europe, and the United States to explore how longitudinal and life course research can be used to study higher education. Highlighting both qualitative and quantitative research, we will explore aspects of social reproduction, inequality, stratification, wellbeing, and school-to-work transitions.