Search results for "quiescence"
showing 5 items of 15 documents
Individual and culture-level components of survey response styles: A multi-level analysis using cultural models of selfhood
2016
Variations in acquiescence and extremity pose substantial threats to the validity of cross-cultural research that relies on survey methods. Individual and cultural correlates of response styles when using 2 contrasting types of response mode were investigated, drawing on data from 55 cultural groups across 33 nations. Using 7 dimensions of self-other relatedness that have often been confounded within the broader distinction between independence and interdependence, our analysis yields more specific understandings of both individual- and culture-level variations in response style. When using a Likert-scale response format, acquiescence is strongest among individuals seeing themselves as simi…
Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain.
2018
The function of somatic stem cells declines with age. Understanding the molecular underpinnings of this decline is key to counteract age-related disease. Here, we report a dramatic drop in the neural stem cells (NSCs) number in the aging murine brain. We find that this smaller stem cell reservoir is protected from full depletion by an increase in quiescence that makes old NSCs more resistant to regenerate the injured brain. Once activated, however, young and old NSCs show similar proliferation and differentiation capacity. Single-cell transcriptomics of NSCs indicate that aging changes NSCs minimally. In the aging brain, niche-derived inflammatory signals and the Wnt antagonist sFRP5 induce…
Acquiescence to opacity
2017
Opacity may affect both the means used to implement policies and the real objectives that they pursue. Our concern with opacity is limited to the cases when it is the result of obfuscation. that is, of some effort on the part of governments or other public bodies (central banks or international organisations) to hide or misrepresent their choices. In the literature concerned with accounting for inefficient policies, there are now models in which opacity plays no significant role. This chapter provides a number of mechanisms that account for or lead to the phenomenon the authors are interested in, that is, voters preferring a policy to be opaque rather than transparent. It then discusses two…
Improved Properties of the Big Five Inventory and the Rosenberg Self-Esteem Scale in the Expanded Format Relative to the Likert Format.
2019
Previous research by Zhang and Savalei (2015) proposed an alternative scale format to the Likert scale format: the Expanded format. Scale items in the Expanded format present both positively worded and negatively worded sentences as response options for each scale item; therefore, they were less affected by the acquiescence bias and method effects that often occur in the Likert scale items. The major goal of the current study is to further demonstrate the superiority of the Expanded format to the Likert format across different psychological scales. Specifically, we aim to replicate the findings of Zhang and Savalei and to determine whether order effect exists in the Expanded format scales. …
Unveiling neural stem cell quiescence: a crosstalk with the extracellular matrix niche
2023
Neural stem cells (NSCs) in the subependymal zone (SEZ) reside in a very specialized microenvironment that tightly regulates their activation state. Three NSC populations coexist in the niche, quiescent (qNSCs), primed and activated (aNSCs), which display unique, actively modulated, molecular identities. One of the specialized extrinsic properties that affect NSC quiescence-to-activation transitions is the extracellular matrix (ECM). The SEZ is the only region in the whole mouse brain that has two basement membrane (BM) structures: vascular and speckled BMs. Further, it displays higher stiffness compared to non-neurogenic areas, suggesting that both composition and ECM properties could part…