Search results for "radionuclide"
showing 10 items of 196 documents
Scandium-44: Benefits of a Long-Lived PET Radionuclide Available from the 44Ti/44Sc Generator System
2011
(44)Ti/(44)Sc radionuclide generators are of interest for molecular imaging. The 3.97 hours half-life of (44)Sc and its high positron branching of 94.27% may stimulate the application of (44)Sc-labeled PET radiopharmaceuticals. This review describes the current status of (44)Ti production, (44)Ti/(44)Sc radionuclide generator development, post-processing of generator eluates towards medical application, identification of ligands adequate to Sc(III) co-ordination chemistry, proof-of-principle labeling of (44)Sc-DOTA-octreotides, investigation of in vitro and in vivo parameters, and initial applications for molecular imaging - both in small animals and humans.
Gamma-ray spectrometric measurement of radionuclide purity of radiopharmaceuticals contained in bottle samples
2012
The radionuclide purity of a radiopharmaceutical product is usually measured by gamma-ray spectrometry with various measurement geometries. The importance of this test is that the radionuclide impurities, if present, result in an increase in the radiation dose to the patient without contributing to diagnostic information and in some cases may also interfere with the marking molecules and affect the proper conduct of diagnostic examination. In this work, gamma-ray spectrometry is used to determine the amounts of impurities by adopting as measurement geometry the same bottle containing eluted or prepared radiopharmaceuticals. In addition to high-purity germanium semiconductor detectors, the u…
PET Chemistry: An Introduction
2021
One major advantage of radioactivity is its extremely high sensitivity of detection. Regarding the medical applicability of radioactivity, it permits non-invasive in vivo detection of radiolabelled compounds at nano- to picomolar levels. The use of substances at such low concentrations usually precludes a physiological, toxic or immunologic response of the investigated biological system. Consequently, the considered physiological process or system is examined in an unswayed situation. Furthermore, a wide range of substances, even those which are toxic at higher concentrations, become considerable for the development of radiopharmaceuticals and use in nuclear medicine. In contrast to the wid…
CERN-MEDICIS: A Review Since Commissioning in 2017
2021
The CERN-MEDICIS (MEDical Isotopes Collected from ISolde) facility has delivered its first radioactive ion beam at CERN (Switzerland) in December 2017 to support the research and development in nuclear medicine using non-conventional radionuclides. Since then, fourteen institutes, including CERN, have joined the collaboration to drive the scientific program of this unique installation and evaluate the needs of the community to improve the research in imaging, diagnostics, radiation therapy and personalized medicine. The facility has been built as an extension of the ISOLDE (Isotope Separator On Line DEvice) facility at CERN. Handling of open radioisotope sources is made possible thanks to i…
Production of mass-separated Erbium-169 towards the first preclinical in vitro investigations
2021
The β−-particle-emitting erbium-169 is a potential radionuclide toward therapy of metastasized cancer diseases. It can be produced in nuclear research reactors, irradiating isotopically-enriched 168Er2O3. This path, however, is not suitable for receptor-targeted radionuclide therapy, where high specific molar activities are required. In this study, an electromagnetic isotope separation technique was applied after neutron irradiation to boost the specific activity by separating 169Er from 168Er targets. The separation efficiency increased up to 0.5% using resonant laser ionization. A subsequent chemical purification process was developed as well as activity standardization of the radionuclid…
Use of sulesomab in the diagnosis of brucellar spondylitis.
2004
ABSTRACT Twenty-two patients with suspected brucellar spondylitis were investigated to evaluate the possible diagnostic role of Sulesomab, a 99m Tc-antigranulocyte antibody Fab' fragment. Sensitivity and specificity were compared with those of magnetic resonance imaging (MRI). Skeletal involvement was detected by MRI in 11 cases, while leukoscintigraphy indicated normal vertebral uptake in seven of these patients, increased uptake in two patients, and decreased uptake in two patients. Leukoscintigraphy of the 11 patients negative by MRI demonstrated increased uptake in two cases. The sensitivity and specificity of leukoscintigraphy were 27.2% and 81.1%, respectively. Based on these results,…
[99mTc]Ca-Phytate: Some colloidal characteristics related to the optimal preparation conditions
1983
Abstract Some physico-chemical characteristics of the colloidal radiopharmaceutical [ 99 m Tc]Ca-phytate related to optimal preparation conditions have been studied. (1,2) It is demonstrated that the Ca 2+ -phytate stoichiometry is 6:1. Two different Ca-phytate colloids seem to be formed, mainly depending on the Ca 2+ :phytate molar ratio-one of low mycelar size for a 1:1 Ca 2+ :phytate molar ratio ( cmc ∗ = 5.10 −5 M ) , and another one, with a higher mycelar size for a 6:1 molar ratio (cmc = 8.10 −5 M). This last one it probably better for providing a good quality splenic uptake.
The activity concentration of post-Chernobyl Cs in the area of the Opole Anomaly (southern Poland)
2015
During the years 2007 and 2010, the activity concentration of 137Cs accumulated in soil, mosses Pleurozium schreberi and lichens Hypogymnia physodes was measured. The studies covered the areas of the so-called Opole Anomaly. In consequence of the Chernobyl nuclear power plant breakdown in 1986, relatively large amounts of this radionuclide were deposited in this area. In some areas of the Anomaly, over 100 times higher surface activity of 137Cs was detected, compared to the lowest values registered in Poland. Currently, 137Cs is still present in woodlands and wastelands. As at 2 April 2013, the surface activity concentration of 137Cs in soil on the tested area was from 0.34 to 67.5 kBq m−2.…
Past, present and future of 68Ge/68Ga generators.
2013
(68)Ga represents one of the very early radionuclides applied to positron emission tomography (PET) imaging at a time when even the wording PET itself was not established. Today it faces a renaissance in terms of new (68)Ge/(68)Ga radionuclide generators, sophisticated (68)Ga radiopharmaceuticals, and state-of-the-art clincial diagnoses via positron emission tomography/computed tomography (PET/CT). Thanks to the pioneering achievement of radiochemists in Obninsk, Russia, a new type of (68)Ge/(68)Ga generators became commercially available in the first years of the 21st century. Generator eluates based on hydrochloric acid provided "cationic" (68)Ga instead of "inert" (68)Ga-complexes, openi…
Laser resonance ionization spectroscopy on lutetium for the MEDICIS project
2017
The MEDICIS-PROMED Innovative Training Network under the Horizon 2020 EU program aims to establish a network of early stage researchers, involving scientific exchange and active cooperation between leading European research institutions, universities, hospitals, and industry. Primary scientific goal is the purpose of providing and testing novel radioisotopes for nuclear medical imaging and radionuclide therapy. Within a closely linked project at CERN, a dedicated electromagnetic mass separator system is presently under installation for production of innovative radiopharmaceutical isotopes at the new CERN-MEDICIS laboratory, directly adjacent to the existing CERN-ISOLDE radioactive ion beam …