Scandium-44: Benefits of a Long-Lived PET Radionuclide Available from the 44Ti/44Sc Generator System

6533b82bfe1ef96bd128e1b2

RESEARCH PRODUCT

Scandium-44: Benefits of a Long-Lived PET Radionuclide Available from the 44Ti/44Sc Generator System

subject

Materials science Transplantation Heterologous Mice Nude chemistry.chemical_element Heterocyclic Compounds 1-Ring Mice Positron Drug Stability Nickel Nuclear Reactors medicine Animals Humans Radiology Nuclear Medicine and imaging Cation Exchange Resins Scandium Chelating Agents Mice nude Radioisotopes Titanium Pharmacology Radionuclide medicine.diagnostic_test Radionuclide Generators Liver Neoplasms Neoplasms Experimental Transplantation chemistry Positron emission tomography Positron-Emission Tomography Puromycin Adsorption Radiopharmaceuticals Radionuclide Generator Molecular imaging Scandium Half-Life Nuclear chemistry

description

(44)Ti/(44)Sc radionuclide generators are of interest for molecular imaging. The 3.97 hours half-life of (44)Sc and its high positron branching of 94.27% may stimulate the application of (44)Sc-labeled PET radiopharmaceuticals. This review describes the current status of (44)Ti production, (44)Ti/(44)Sc radionuclide generator development, post-processing of generator eluates towards medical application, identification of ligands adequate to Sc(III) co-ordination chemistry, proof-of-principle labeling of (44)Sc-DOTA-octreotides, investigation of in vitro and in vivo parameters, and initial applications for molecular imaging - both in small animals and humans.

year	journal	country	edition	language
2011-12-09	Current Radiopharmaceuticals

https://doi.org/10.2174/1874471011205030187

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