Search results for "rafts"

Bioengineering Thymus Organoids to Restore Thymic Function and Induce Donor-Specific Immune Tolerance to Allografts.

2015

One of the major obstacles in organ transplantation is to establish immune tolerance of allografts. Although immunosuppressive drugs can prevent graft rejection to a certain degree, their efficacies are limited, transient, and associated with severe side effects. Induction of thymic central tolerance to allografts remains challenging, largely because of the difficulty of maintaining donor thymic epithelial cells in vitro to allow successful bioengineering. Here, the authors show that three-dimensional scaffolds generated from decellularized mouse thymus can support thymic epithelial cell survival in culture and maintain their unique molecular properties. When transplanted into athymic nude …

The use of normothermic machine perfusion to rescue liver allografts from expanded criteria donors

2021

The use of expanded criteria donors is one of the strategies used to overcome the gap between the demand for organs and the number of donors. Physicians debate the extent to which marginal grafts can be used. In recent years, normothermic machine perfusion (NMP) has been used to test liver viability before transplantation. Grafts underwent NMP whenever histological steatosis was > 40% or there were at least three Eurotransplant criteria for expanded criteria donor (ECD). We used NMP to test 19 grafts, 3 from donation after type 3 controlled cardiac death (DCD), and 16 from donation after brain death (DBD). Only two grafts from DBD were not transplanted, because perfusion proved they were…

Should kidney allografts from old donors be allocated only to old recipients?

2020

Contains fulltext : 226016.pdf (Publisher’s version ) (Closed access) In several deceased donor kidney allocation systems, organs from elderly donors are allocated primarily to elderly recipients. The Eurotransplant Senior Program (ESP) was implemented in 1999, and since then, especially in Europe, the use of organs from elderly donors has steadily increased. The proportion of ≥60-year-old donors reported to the Collaborative Transplant Study (CTS) by European centers has doubled, from 21% in 2000-2001 to 42% in 2016-2017. Therefore, in the era of organ shortage it is a matter of debate whether kidney organs from elderly donors should only be allocated to elderly recipients or whether <65-y…

La funzione tecnica e il mestiere dell'artigiano nella Grecia antica tra merito e responsabilità. Una rassegna critica

2017

This paper is a critical essay on the social value of craftsmen in ancient Greece as well of the merit and ethic responsibility connected to the social use of their skills and forms of knowledge, the so-called technai. On one hand a low grade of social consideration was attributed to craftsmen, especially among the upper classes in the Greek cities; on the other hand, craft and technical skills were an essential medium for all the material products and commodities to be supplied for the citizens. The origins of this ambiguous relationship between society and technical skills seem to lie in the particular social and political conditions of Greek craftsmen, mostly foreign people at the dispos…

Iron Age craftworks in the southeast of the Iberian Peninsula. An approach based in Cultural Inheritance Theory

2021

Este trabajo tiene por objeto realizar una aproximación a las artesanías sobre materias duras de origen animal durante la Edad del Hierro en la PI y al estudio de los materiales como un medio para acercarnos a la sociedad que los produjo.  La problemática abordada contempla los procesos de la producción artesanal, la transmisión del conocimiento y la circulación de algunos de estos bienes. Hemos elegido dos tipos de piezas singulares: los peines de marfil y las placas de telar de hueso. Consideramos que este tipo de producciones constituye un fenómeno complejo y conforma una práctica cultural que recrea con códigos propios los gustos y la demanda de la época. A nivel metodológico, la Théori…

Functional outcomes of peripheral nerve repair and regeneration: clinical and experimental study

This study investigated pre- and post-operative evaluation of peripheral nerve injuries and functional outcomes of peripheral nerve regeneration after different type of injuries and different type of treatments. Neuromas/scar neuritis and brachial plexus injuries are specifically addressed; literature and experimental evidence on the outcomes of vascularized nerve grafts are presented.

W mieście i na wsi. Symbole działalności rzemieślniczej i zawodowej na wybranych pieczęciach z zasobu Archiwum Państwowego w Opolu (XVI-1.poł. XX w.)

2021

Pieczęcie oprócz funkcji prawnej zawierają też istotny element komunikacyjny. W artykule przeanalizowano wybrane śląskie pieczęcie nawiązujące do działalności zawodowej ludności, które były używane w kancelariach miejskich, cechów rzemieślniczych oraz przez gminy wiejskie. Zidentyfikowano symbole poszukując typowych przedstawień dla określonych grup dysponentów.

The world is your oyster! : a material package for teaching handcrafts through CLIL

2014

Globalisoituvassa, verkottuvassa ja monikulttuuristuvassa maailmassa kyky kommunikoida vierailla kielillä ja kulttuurien tuntemus muuttuvat yhä tärkeämmiksi taidoiksi, joita myös suomalaisen koulun on kyettävä välittämään oppilaille. Eräs lähestymistapa tämän tavoitteen toteuttamiseksi on Content and Language Integrated Learning eli CLIL, jonka mukaisessa opetuksessa keskitytään sekä käytetyn vieraan kielen että käsiteltävänä olevan oppiaineen sisällön oppimiseen. CLIL mahdollistaa vieraan kielen käytön paitsi oppimisen kohteena, myös sen välineenä, mikä kasvattaa oppilaiden kommunikaatiotaitoja ja motivaatiota kielen oppimiseen. Tämä opinnäytetyö tarjoaa opettajien käyttöön oppimateriaalip…