Search results for "rasa"
showing 10 items of 125 documents
Safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of the novel enzyme replacement therapy avalglucosidase alfa (neoG…
2019
This multicenter/multinational, open-label, ascending-dose study (NCT01898364) evaluated safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of repeat-dose avalglucosidase alfa (neoGAA), a second-generation, recombinant acid α-glucosidase replacement therapy, in late-onset Pompe disease (LOPD). Patients ≥18 years, alglucosidase alfa naïve (Naïve) or previously receiving alglucosidase alfa for ≥9 months (Switch), with baseline FVC ≥50% predicted and independently ambulatory, received every-other-week avalglucosidase alfa 5, 10, or 20 mg/kg over 24 weeks. 9/10 Naïve and 12/14 Switch patients completed the study. Avalglucosidase alfa was well-tolerated; no deaths…
Spacer-separated sialyl LewisX cyclopeptide conjugates as potential E-selectin ligands.
2006
Completely protected sialyl LewisX azide was synthesized from a neolactosamine azide precursor carrying a 3-O-allyloxycarbonyl group as the temporary protecting group. After its Pd(0)-catalyzed deprotection and stereoselective alpha-fucosylation, the obtained LewisX azide was subjected to O-deacetylation in the galactose unit and subsequent regio- and stereoselective sialylation. Reduction of the anomeric azido group afforded the sialyl LewisX amine building block. Two molecules of this tetrasaccharide ligand were conjugated to a preformed cyclooctapeptide containing two equidistant l-asparagine units equipped with carboxy-terminated tetraethyleneglycol side chains to give, after deprotecti…
Total and Subtypes of Dietary Fat Intake and its Association with Components of the Metabolic Syndrome in a Mediterranean Population at High Cardiova…
2019
Background: The effect of dietary fat intake on the metabolic syndrome (MetS) and in turn on cardiovascular disease (CVD) remains unclear in individuals at high CVD risk. Objective: To assess the association between fat intake and MetS components in an adult Mediterranean population at high CVD risk. Design: Baseline assessment of nutritional adequacy in participants (n = 6560, men and women, 55&ndash
Zīda fibroīna izdalīšana apatītu kompozītmateriālu modificēšanai
2022
Zīda fibroīna izdalīšana apatītu kompozītmateriālu modificēšanai. Kleinberga A., zinātniskais vadītājs Dr. chem., doc. Agnese Osīte. Bakalaura darbs, 42 lappuses, 30 attēli, 10 tabulas, 53 literatūras avoti, 4 pielikumi. Latviešu valodā. Darbā veikta hidroksilapatīta sintēze, izdalīts zīda fibroīns no Bombyx mori zīda kokoniem un veikta to analīze ar FTIR, XRD u.c. metodēm. Apkopota literatūras informācija par hidroksilapatītiem, to izmantošanu un analīžu metodēm. Kā arī apkopota informācija par zīda šķiedrām, to attīrīšanas un analīžu metodēm, kā arī izmantošanu. Hidroksilapatīta kristāliskās struktūras raksturošanai tika izmantots Rentgenstaru difraktometrs. Hidroksilapatīta un zīda fibro…
Junceosides A-C, new triterpene saponins from Arenaria juncea.
2002
Three novel triterpenoid saponins, junceosides A (1), B (2), and C (3), together with two known saponins have been isolated from the roots of Arenaria juncea. Their structures were elucidated using a combination of homo- and heteronuclear 2D NMR techniques (COSY, TOCSY, NOESY, HSQC, and HMBC) and by FABMS. The new compounds were characterized as 3-O-alpha-L-arabinopyranosyl-(1-->2)-[beta-D-galactopyranosyl-(1-->3)]-beta-D-glucuronopyranosylgypsogenin-28-O-beta-D-glucopyranosyl(1-->3)-[beta-D-xylopyranosyl-(1-->4)]-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-fucopyranoside (1), 3-O-alpha-L-arabinopyranosyl-(1-->2)-[beta-D-galactopyranosyl-(1-->3)]-beta-D-glucuronopyranosylgypsogenin-28-O-beta-D-x…
Réponses des cellules de Nicotiana tabacum à des molécules microbiennes : évènements de signalisation précoce, influence de la dynamique membranaire …
2018
In their natural environment plants are in close interaction with beneficial, neutral, or pathogenic microbes, which are highly dependent on carbon resources exuded by plant roots. Sugar transport, which is a key process of plant physiology, is essential to support the fate of plant-microbe interactions. During evolution, plants have acquired the ability to perceive microbial molecules, initiating specific signal transduction cascades and leading to adapted response for microbe lifestyles (avirulent, virulent, or benefic). Plant survival will depend on the nature of the induced mechanisms. My PhD work, carried out on a simplified experimental system, contributes to the understanding of mech…
Potential predictability of crop impacting climate variables for East Africa and application to sorghum in the Mt Kenya area
2013
In Southern countries with rural low income populations, the vulnerability of rainfed agriculture to rainfall variability requires effective solutions to mitigate the effects of climatic hazards on crops. Predicting the characteristics of rainy seasons some time before they start should help the establishment of agricultural adaptation strategies to rainfall hazards. This is the objective of the present study, focused on East Africa (Kenya and northern Tanzania), and divided in three parts:- Define and document intra-seasonal descriptors (ISD) that will be considered in the predictability study. A new methodological approach has been developed in order to define the onset date (ORS) and the…
Prasa polskiej emigracji politycznej w Wielkiej Brytanii wobec protestów robotników w kraju w czerwcu 1976 roku
2016
Strajki i demonstracje w Polsce, do których doszło 25 czerwca 1976 r. odbiły się żywym echem wśród emigracji w Wielkiej Brytanii. W artykule przedstawiono opinie i oceny emigracyjnych polityków oraz publicystów dotyczące przyczyn, przebiegu i konsekwencji czerwcowych protestów w kraju.
Zvaigžņotā Debess: 2011, Vasara (212)
2011
Contents: “ZVAIGŽŅOTĀ DEBESS” FORTY YEARS AGO: A.Balklavs. Extremely Distant New Objects of Metagalaxy (abridged) ; Newspaper „Literaturnaja Rossija” 9 April 1971. Astronautics: Yesterday, Today, Tomorrow (abridged) ; CONFERENCE “The VIEW from SPACE. FIRST MANNED SPACE FLIGHT – 50”: M.Gills. Conference on the Eve of Human Space Flight Anniversary ; J.Ekmanis, S.Negrejeva. Mstislav Keldysh and Golden Age of Soviet Science ; T.Millers. Contribution of Scientists of the Institute of Inorganic Chemistry to the Development of Space Technologies and Materials ; G.Vilka. Remembrance of Friedrich Zander in Rīga ; O.Plepis. My Contribution to the Development of Space Medicine ; J.Stradiņš. Latvia’s …
Dimensión socio-laboral de las relaciones comerciales trasatlánticas: algunas lecciones del pasado.
2022
En la cumbre UE-EE.UU. del pasado 15 de junio de 2021, la Unión Europea y los Estados Unidos realizaron una declaración conjunta en la que anunciaron una asociación transatlántica renovada para la era posterior a la pandemia. De manera que en el momento en el que se refuerzan las negociaciones comerciales entre la UE y EE.UU. vale la pena analizar hasta dónde se llegó en las negociaciones del Acuerdo Transatlántico sobre Comercio e Inversión en el marco de la OMC, en particular en relación a los aspectos más controvertidos desde la perspectiva social. Lo que incluye un análisis comparado específicamente enfocado al tratamiento del desplazamiento de trabajadores en el AGCS y en la Directiva …