Search results for "rck"
showing 10 items of 31 documents
Ranke, Burckhardt e il "rinascimento orientale"
2020
Il saggio ricostruisce le reazioni di Ranke e di Burckhardt al "Rinascimento Orientale" del romanticismo e della cultura del tardo Ottocento. I temi trattati riguardano il tema della violenza nella storia, il significato del "sacrificio", il pericolo dell'anonimato e del quantitativo nella vita metropolitana. Un riferimento importante è svolto nel saggio da Quinet, cui si ricorre come a un "fil rouge". What stance on “Eastern Renaissance” did Ranke and Burckhardt take? This subject needed to make a survey of the German-Romantic idea of the East, focusing on Herder’s anthropology. Notoriously, Ranke and Burckhardt were very different historians, but they shared a negative opinion on “Eastern…
Curcumin modulates chronic myelogenous leukemia exosomes composition and affects angiogenic phenotype, via exosomal miR-21
2016
Abstract: Tumor derived exosomes are vesicles which contain proteins and microRNAs that mediate cell-cell communication and are involved in angiogenesis and tumor progression. Curcumin derived from the plant Curcuma longa, shows anticancer effects. Exosomes released by CML cells treated with Curcumin contain a high amount of miR-21 that is shuttled into the endothelial cells in a biologically active form. The treatment of HUVECs with CML Curcu-exosomes reduced RhoB expression and negatively modulated endothelial cells motility. We showed that the addition of CML control exosomes to HUVECs caused an increase in IL8 and VCAM1 levels, but Curcu-exosomes reversed these effects thus attenuating …
Canova divulgato tra «Können» e «Wollen» nell’opera di Alfred Gotthold Meyer
2014
This article is a critical introduction to the Italian translation of Meyer's Canova monograph (1898), it focuses on the editorial process and on the use of photography during this early stage of popular art history. Further consideration is given to Meyer's critical point of view in the context of the German fin-de-siècle art discourse (Burckhardt, Springer, Bode, Wölfflin, Hildebrand).
Kauppaneuvos Bernt Starckjohann (1923–1997)
2017
Solid-Phase Synthesis and Biological Evaluation of a Teleocidin Library—Discovery of a Selective PKC Down Regulator
2000
Protein kinaseC (PKC) is linked to the signal-induced modulation of a wide variety of cellular processes, such as growth, differentiation, secretion, apoptosis, and tumor development. The design and synthesis of small molecules that regulate these different cellular signaling systems is at the forefront of modern drug design. Herein we report a) an efficient method for the synthesis of indolactamV (6), a PKC activator, and its N13-des(methyl) analogues (19) using a regioselective organometallic transformation, a convenient aminomalonate derivative (10) to introduce the appropriate functionality and an enantiospecific enzymic hydrolysis as key steps; b) the use of this method in the first so…
Expression of protein kinase C gene family members is temporally and spatially regulated during neural development in vitro.
1998
We used primary cultures of rat hippocampal neurons and PCC7-Mz1 cells to correlate the expression of the protein kinase C (PKC) gene family with specific events during neural differentiation. Multipotent PCC7-Mz1 embryonic carcinoma stem cells develop into a tissue-like pattern of neuronal, fibroblast-like and astroglial cells by all-trans retinoic acid (RA) treatment. Western blot analyses demonstrate that PKCalpha, betaI, gamma, theta, mu, lambda, and zeta were constitutively expressed but the expression of PKCbetaII, delta, epsilon, and eta was up-regulated three days after addition of RA when cells mature morphologically. While the protein levels of the PKC isoforms betaII, delta and e…
1793 - I BENI NATURALI DIVENTANO BENI CULTURALI
2009
Il 1793 fu l’anno in cui l’istruzione fu riformata in Francia. Erano passati quattro anni dalla Rivoluzione e si imponevano nuovi criteri per l’insegnamento delle Scienze Naturali, che dovevano diventare la base di una nuova cultura, più attenta a tutti i viventi e meno antropocentrica. Come emblemi del passato, le Chiese venivano chiuse, o dedicate ad altre funzioni: così stava per succedere alla Chiesa di Saint Sulpice a Parigi che, dopo una grande festa popolare di inaugurazione, doveva diventare Tempio della Filosofia. Il periodo era assai turbolento e pericoloso, tanto che fu in seguito chiamato Terrore. Il Governo stesso temeva distruzioni e atti di vandalismo, soprattutto verso due s…
Iris bismarckiana in Israel and Jordan—New findings and taxonomic remarks
2001
Iris bismarckiana (Iris section Oncocyclus) was found for the first time in the west Gilead in Jordan. This discovery was utilized to shed some light on the taxonomic relationships among the light-colored irises in the Levant. Morphometric quantitative analysis of the Jordanian population compared to I. bismarckiana allies in Israel (I. bismarckiana in the Galilee and I. hermona in the Golan) suggests that the Jordanian population is I. bismarckiana, despite the large distance from the main distribution area. Cluster analysis, based on the morphology, revealed that some of the populations of I. bismarckiana have closer affinities to I. hermona than to each other. Populations of I. hermona a…
Data from: Phylogenomics of Lophotrochozoa with consideration of systematic error
2021
Phylogenomic studies have improved understanding of deep metazoan phylogeny and show promise for resolving incongruences among analyses based on limited numbers of loci. One region of the animal tree that has been especially difficult to resolve, even with phylogenomic approaches, is relationships within Lophotrochozoa (the animal clade that includes molluscs, annelids, and flatworms among others). Lack of resolution in phylogenomic analyses could be due to insufficient phylogenetic signal, limitations in taxon and/or gene sampling, or systematic error. Here, we investigated why lophotrochozoan phylogeny has been such a difficult question to answer by identifying and reducing sources of sys…
Data from: Phylogenomics of Lophotrochozoa with consideration of systematic error
2016
Phylogenomic studies have improved understanding of deep metazoan phylogeny and show promise for resolving incongruences among analyses based on limited numbers of loci. One region of the animal tree that has been especially difficult to resolve, even with phylogenomic approaches, is relationships within Lophotrochozoa (the animal clade that includes molluscs, annelids, and flatworms among others). Lack of resolution in phylogenomic analyses could be due to insufficient phylogenetic signal, limitations in taxon and/or gene sampling, or systematic error. Here, we investigated why lophotrochozoan phylogeny has been such a difficult question to answer by identifying and reducing sources of sys…