Search results for "regeneration"
showing 10 items of 889 documents
In vitro and in vivo characterization of porcine acellular dermal matrix for gingival augmentation procedures
2013
Recently, porcine acellular dermal matrix (PADM) has been proposed as a possible alternative to autogenous grafts in periodontal plastic surgery. The aim of the present study was to investigate the in vitro responses of four different oral cell lines cultured on a novel PADM. Furthermore, tissue reaction to PADM was evaluated histologically after subcutaneous implantation in mice.Human gingival fibroblasts (HGF), human osteoblast-like cells, human umbilical vein endothelial cells and human oral keratinocytes (HOK) were cultured and transferred on to the PADM. A tissue culture polystyrene surface served as the control. The viability of all tested cell lines on PADM was measured by using the …
Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk
2014
A fundamental goal in cancer biology is to identify the cells and signalling pathways that are keys to induce tumour regression. Here we use a spontaneously self-regressing tumour, cutaneous keratoacanthoma (KAs), to identify physiological mechanisms that drive tumour regression. By using a mouse model system that recapitulates the behaviour of human KAs, we show that self-regressing tumours shift their balance to a differentiation programme during regression. Furthermore, we demonstrate that developmental programs utilized for skin hair follicle regeneration, such as Wnt, are hijacked to sustain tumour growth and that the retinoic acid (RA) signalling pathway promotes tumour regression by …
The Sustainable Energy Action Plan. A Sicilian case study
2012
The European Union, to reach the objective of the emission reduction, has introduced several projects, including the “Convenant of Mayors”, vo-luntary action aimed to involve the cities of the European Community in the process towards environmental and enrgetic sustainability. Over 2100 muni-cipalities in Europe have joined or are in the process of ratification, but for the 954 italians signatories, only four have drawn up the required tools. The case study "Lampedusa" (presented by the writer as a master's thesis CasaClima - speaker arch. Fattor S., Co-prof. Trombino) comes from the de-sire to measure, in a Sicilian reality, multidisci-disciplinary approaches to de-fine strategic planning …
Diluire Mondello Descrizioni per un progetto
2012
Il volume pubblica i materiali originali del concorso internazionale di idee per la riqualificazione urbana di Mondello, una localita balneare della costa settentrionale di Palermo. Concorso vinto dall'autore stesso. Il libro utilizza questa occasione di riflessione a partire da una occasione concreta di trasformazione, per affrontare criticamente le questioni scientifico disciplinari legate al tema del Landscape Urbanism e alle evoluzioni contemporanee della nozione di Progetto Urbano. Il volume ripercorre i contributi critici e teorici della disciplina degli ultimi vent'anni e propone un'avanzamento critico delle teorie sul paesaggio urbano e sulle geografie della città contemporanea. Il …
Ad “Uso e Consumo” del suolo
2021
Parlare di consumo di suolo significa affrontare di una questione attuale che pone le sue basi in una lunga storia complessa e articolata. La complessità e l'incertezza del concetto di consumo di suolo è da ricercare anche nella sua storia che è legata a quella dell'uso del suolo. Pertanto, definire chiaramente il termine consumo di suolo è difficile nonostante una ricca letteratura sull'argomento sia oggi disponibile. Si potrebbe dire che il consumo di suolo deve essere inteso come un processo antropico che opera una trasformazione, attraverso la realizzazione, soprattutto nelle aree agricole, di infrastrutture di vario tipo che spesso distruggono le caratteristiche ambientali del territor…
Increased hepatic fibrosis and JNK2-dependent liver injury in mice exhibiting hepatocyte-specific deletion of cFLIP.
2012
Chronic liver disease promotes hepatocellular injury involving apoptosis and triggers compensatory regeneration that leads to the activation of quiescent stellate cells in the liver. The deposition of extracellular matrix from activated myofibroblasts promotes hepatic fibrosis and the progression to cirrhosis with deleterious effects on liver physiology. The role of apoptosis signaling pathways in the development of fibrosis remains undefined. The aim of the current study was to determine the involvement of the caspase-8 homologue cellular FLICE-inhibitory protein (cFLIP) during the initiation and progression of fibrosis. Liver injury and fibrosis from carbon tetrachloride (CCl4) and thioa…
Liver stiffness measurement in patients with nodular regenerative hyperplasia undergoing magnetic resonance elastography
2020
Purpose Nodular regenerative hyperplasia (NRH) may mimic cirrhosis at imaging. We aim to investigate the effect of NRH on liver stiffness measurement (LSM) obtained with magnetic resonance elastography (MRE).Methods This retrospective, Institutional Review Board-approved study included 37 subjects with NRH (Group 1) and no or minimal fibrosis (F0-F1), a control group (Group 2) made of 30 subjects with non-advanced fibrosis (F0-F2), and a control group (Group 3) made of 30 subjects with advanced fibrosis (F3-F4), all with available MRE. LSM was measured in each subject along with assessment of hepatic morphological features of cirrhosis and signs of portal hypertension. The significance of t…
StellaTUM: current consensus and discussion on pancreatic stellate cell research
2011
The field of pancreatic stellate cell (PSC) biology is very young, as the essential in-vitro tools to study these cells (ie, methods to isolate and culture PSC) were only developed as recently as in 1998. Nonetheless, there has been an exponential increase in research output in this field over the past decade, with numerous research groups around the world focusing their energies into elucidating the biology and function of these cells. It is now well established that PSC are responsible for producing the stromal reaction (fibrosis) of two major diseases of the pancreas—chronic pancreatitis and pancreatic cancer. Despite exponentially increasing data, the methods for studying PSC remain var…
Rilpivirine attenuates liver fibrosis through selective STAT1-mediated apoptosis in hepatic stellate cells
2020
ObjectiveLiver fibrosis constitutes a major health problem worldwide due to its rapidly increasing prevalence and the lack of specific and effective treatments. Growing evidence suggests that signalling through cytokine-activated Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathways regulates liver fibrosis and regeneration. Rilpivirine (RPV) is a widely used anti-HIV drug not reported to produce hepatotoxicity. We aimed to describe the potential hepatoprotective effects of RPV in different models of chronic liver injury, focusing on JAK-STAT signalling regulation.DesignThe effects of RPV on hepatic steatosis, inflammation and fibrogenesis were studied in a nut…