Search results for "regulation"

Absorptive Capacity and Social Capital: Innovation and Environmental Regulation

2010

Norwegian paper and pulp mills are subject to strict environmental regulation. The mills conduct research and development for reducing pollution. Absorptive capacity indicates their competence. Firms are part of a social network of connections with external actors that include other paper and pulp mills, suppliers, customers, research institutes, and universities that help them in developing technologies. These relations represent their social capital. Some firms have access to more and better resources than other firms. Measuring firms’ absorptive capacity and access to social capital, we analyze their success in reducing pollution levels. There is a strong interaction effect between absor…

Ethical Climate as Social Norm: Impact on Judgements and Behavioral Intentions in the Workplace.

2021

We present a study that looks at the relationship between the ethical climate, considered as a set of social norms, and judgments and behaviors in the workplace. In this case we think that an ethical rule reflecting the climate is only actualized in conduct and/or decisions if the rule is applicable, is shared, and is the subject of social expectations. A total of 277 professionals responded to a questionnaire measuring the normativity of three ethical rules, socio-moral judgment, trust in supervisors, turnover intention, and discrimination as well as abusive supervision. The results confirm our hypothesis. This leads to a different view of how the ethical climate is measured and constructe…

Diverse stress signals activate the C1 subgroup MAP kinases ofArabidopsis

2007

AbstractMitogen-activated protein kinase (MAPK) cascades play an important role in mediating stress responses in plants. In Arabidopsis, 20 MAPKs have been identified and classified into four major groups (A–D). Little is known about the role of group C MAPKs. We have studied the activation of Arabidopsis subgroup C1 MAPKs (AtMPK1/AtMPK2) in response to mechanical injury. An increase in their kinase activity was detected in response to wounding that was blocked by cycloheximide. Jasmonic acid (JA) activated AtMPK1/AtMPK2 in the absence of wounding. Wound and JA-induction of AtMPK1/2 kinase activity was not prevented in the JA-insensitive coi1 mutant. Other stress signals, such as abscisic a…

Integration of polyamins in the cold acclimation response

2011

8 páginas, 1 figura, 3 tablas -- PAGS nros. 31-38

Regulation of antibiotic biosynthesis in Actinomycetes.

2013

Isoquercitrin and polyphosphate co-enhance mineralization of human osteoblast-like SaOS-2 cells via separate activation of two RUNX2 cofactors AFT6 a…

2014

Isoquercitrin, a dietary phytoestrogen, is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. Here we studied the combined effects of isoquercitrin, a cell membrane permeable 3-O-glucoside of quercetin, and polyphosphate [polyP], a naturally occurring inorganic polymer inducing bone formation, on mineralization of human osteoblast-like SaOS-2 cells. Both compounds isoquercitrin and polyP induce at non-toxic concentrations the mineralization process of SaOS-2 cells. Co-incubation experiments revealed that isoquercitrin (at 0.1 and 0.3μM), if given simultaneously with polyP (as Ca(2+) salt; at 3, 10, 30 and 100μM) amplifies the mineralization-enhanci…

Mobile Phone Data Statistics as Proxy Indicator for Regional Economic Activity Assessment

2019

The mobile data analysis is an authoritative source of information for problems solving in the fields of human activity recognition, population dynamics, tourism, transport planning, traffics measuring, public administration and other activities and could be the source for valuable information as a proxy indicator. One of the obstacles to user data from mobile operators is compliance to the General Data Protection Regulation, so the development of data analytics approach that protects personal data without a necessity to identify mobility of particular persons was developed, that still provides economically relevant data. In the present research, the method for the economic activity assessm…

Not Entirely Reliable: Private Scientific Organizations and Risk Regulation – The Case of Electromagnetic Fields

2013

Private scientific organizations exert a great deal of influence in the regulation of some technological risks. The high level of expertise of their members is arguably a good reason for them to participate in making and monitoring risk regulations, in order to adjust these to scientific progress. Nevertheless, there are also sound reasons why governments shouldn’t uncritically follow the views expressed by such organizations. Taking the role played by the International Commission on Non–Ionizing Radiation Protection in the regulation of electromagnetic fields as an illustrative example, this paper shows that private scientific organizations such as these are structurally less well suited t…

Blastic plasmacytoid dendritic cell neoplasm: genomics mark epigenetic dysregulation as a primary therapeutic target

2018

Blastic Plasmacytoid Dendritic Cell Neoplasm is a rare and aggressive hematological malignancy currently lacking an effective therapy. To possibly identify genetic alterations useful for a new treatment design, we analyzed by whole-exome sequencing fourteen Blastic Plasmacytoid Dendritic Cell Neoplasm patients and the patient-derived CAL-1 cell line. The functional enrichment analysis of mutational data reported the epigenetic regulatory program as the most significantly undermined (P<.0001). In particular, twenty-five epigenetic-modifiers were found mutated (e.g., ASXL1, TET2, SUZ12, ARID1A, PHF2, CHD8); ASXL1 was the most frequently affected (28.6% of cases). To evaluate the impact of …

Role of microglia in blood pressure and respiratory responses to acute hypoxic exposure in rats

2021

AbstractMicroglia modulate cardiorespiratory activities during chronic hypoxia. It has not been clarified whether microglia are involved in the cardiorespiratory responses to acute hypoxia. Here we investigated this issue by comparing cardiorespiratory responses to two levels of acute hypoxia (13% O2 for 4 min and 7% O2 for 5 min) in conscious unrestrained rats before and after systemic injection of minocycline (MINO), an inhibitor of microglia activation. MINO increased blood pressure but not lung ventilation in the control normoxic condition. Acute hypoxia stimulated cardiorespiratory responses in MINO-untreated rats. MINO failed to significantly affect the magnitude of hypoxia-induced bl…