Search results for "relap"

Dimethyl fumarate vs Teriflunomide: an Italian time-to-event data analysis

2020

The introduction of oral disease-modifying therapies (DMTs) for relapsing-remitting multiple sclerosis (RRMS) changed the therapeutic landscape and algorithms of RRMS treatment (1). In Europe, dimethyl fumarate (DMF) and teriflunomide (TRF) are approved as first-line agents and are often used as the initial therapeutic choice (2, 3). Pivotal trials showed the efficacy of both DMTs on controlling clinical relapses, disability accrual and magnetic resonance imaging (MRI) activity (4-8). Both DMTs had overall good tolerability. There have been no head-to-head randomized trials to compare these two DMTs; however, several real-world evidence (RWE) studies have compared DMF and TRF and provided u…

Borrelia miyamotoi is widespread in Ixodes ricinus ticks in southern Norway.

2015

From April to October 2007, host-seeking Ixodes ricinus ticks were collected from four locations in southern Norway; Farsund, Mandal, Sogne and Tromoy, respectively. Larvae (n=210), nymphs (n=1130) and adults (n=449) were investigated for infection with Borrelia miyamotoi by real-time polymerase chain reaction (PCR) amplification of part of the 16S rRNA gene. Results were verified by direct sequencing of the PCR amplicon generated from the rrs (16S)-rrl (23S) intergenetic spacer. B. miyamotoi was detected at all sites and throughout the period of questing activity, with infection prevalence (≤1.26%) similar to what has been seen in other European countries. Detection of the relapsing fever …

Articaine versus lidocaine inferior alveolar nerve block in posterior mandible implant surgeries: a randomized controlled trial

2023

Background: The aim of this study is to compare the effects of %4 articaine and %2 lidocaine on inferior alveolar nerve block (IANB) for implant surgery in the posterior mandible.Material and Methods: The patients who have inserted implants in the posterior mandible were divided into 2 groups for IANB: lidocaine and articaine. VAS = visual analog scale, pain during surgery and injection, lip numb-ness time, mandibular canal-implant apex distance, age, gender, bone density, implant number, release incision, adjacent teeth, and duration of surgery were analyzed using t-test, Mann-Whitney U test, Spearman's coefficient, and, Pearson's chi-squared test. This trial followed the recommendations o…

Effect of sulpiride in endogenous depression.

1984

Clinical practice and pharmacological data suggest a possible antidepressive action of sulpiride given in low dosages. To further explore the therapeutic efficacy of sulpiride 11 patients with an endogenous type of depression were studied during treatment with an oral daily dose of 150 mg sulpiride. The present data allows the conclusion that (A) low dosed sulpiride seems to act as an antidepressant in severe and milder forms of depression, (B) a clinical progress is seen earlier than is common during treatment with tricyclics and (C) a significant increase of drive is observable. However, sulpiride maintenance therapy did not prevent early relapse into depression. The preliminary nature of…

Pre-Clinical Studies with D-Penicillamine as a Novel Pharmacological Strategy to Treat Alcoholism: Updated Evidences

2017

Ethanol, as other drugs of abuse, is able to activate the ventral tegmental area dopamine (VTA-DA) neurons leading to positively motivational alcohol-seeking behavior and use, and, ultimately to ethanol addiction. In the last decades, the involvement of brain-derived acetaldehyde (ACD) in the ethanol actions in the mesolimbic pathway has been widely demonstrated. Consistent published results have provided a mechanistic support to the use of ACD inactivating agents to block the motivational and reinforcing properties of ethanol. Hence, in the last years, several pre-clinical studies have been performed in order to analyze the effects of the sequestering ACD agents in the prevention of ethano…

The control of abstinence in the treatment of alcohol dependence: the use of acamprosate in relapse prevention

2014

"The alcoholism can also deal with drug treatments." This is the message that emerges from the press conference of presentation of Campral, trade name of acamprosate, a neuromodulator specifically indicated in the maintenance of abstinence in alcohol-dependent patients.Alcoholism is a disease characterized by: craving, loss of control, tolerance and physical dependence.For many years the prevention of relapse in use of alcohol after detoxification was supported almost exclusively by psychosocial procedures and techniques with modest success. Treatment with acamprosate is a valid tool to complement psychotherapy as it does not cause addiction, abuse or withdrawal of its suspension and does n…

Thermalhydraulic analyses of overpower transients in the EFIT reactor

2008

Analysis of Protected Accidental Transients in the EFIT Reactor With the RELAP5 Thermal-Hydraulic Code

2008

The European Facility for Industrial Transmutation (EFIT) is aimed at demonstrating the feasibility of transmutation process through the Accelerator Driven System (ADS) route on an industrial scale. The conceptual design of this reactor of about 400 MW thermal power is under development in the frame of the European EUROTRANS Integrated Project of the EURATOM Sixth Framework Program (FP6). EFIT is a pool-type reactor cooled by forced circulation of lead in the primary system where the heat is removed by steam generators installed inside the reactor vessel. The reactor power is sustained by a spallation neutron source supplied by a proton beam impinging on a lead target at the core centre. A …

TRACE and RELAP5 Codes for Beyond Design Accident Condition Simulation in the SPES3 Facility

2012

Code validation on qualified experimental data is a fundamental issue in the design and safety analyses of nuclear power plants. The SPES3 facility is being built at the SIET laboratories for an integral type SMR simulation, in the frame of an R&D program on nuclear fission, funded by the Italian Ministry of Economic Development and led by ENEA. The facility, based on the IRIS reactor design, reproduces the primary, secondary and containment systems with 1:100 volume scale, full elevation and prototypical fluid and thermal-hydraulic conditions. It is suitable to test the plant response to design and beyond design accidents in order to verify the effectiveness of the primary and containm…

P-78D-PENICILLAMINE PREVENTS THE ALCOHOL DEPRIVATION EFFECT IN THE OPERANT SELF-AMINISTRATION PARADIGM

2015

Although pharmacological treatments for relapse prevention have experienced some progress, their general effectiveness can be considered low and the problem could not be considered solved. In recent years, our group has explored the use of acetaldehyde (ACD) sequestering agents as a new and very promising strategy. These agents, such as …