Search results for "relation"
showing 10 items of 10542 documents
Dual targeting of higher-order DNA structures by azacryptands induces DNA junction-mediated DNA damage in cancer cells
2021
Abstract DNA is intrinsically dynamic and folds transiently into alternative higher-order structures such as G-quadruplexes (G4s) and three-way DNA junctions (TWJs). G4s and TWJs can be stabilised by small molecules (ligands) that have high chemotherapeutic potential, either as standalone DNA damaging agents or combined in synthetic lethality strategies. While previous approaches have claimed to use ligands that specifically target either G4s or TWJs, we report here on a new approach in which ligands targeting both TWJs and G4s in vitro demonstrate cellular effects distinct from that of G4 ligands, and attributable to TWJ targeting. The DNA binding modes of these new, dual TWJ-/G4-ligands w…
Utilización de muestras clínicas para la investigación científica
2004

 SUMARIO: 1. Introducción. 2. Clasificación de las muestras con fundamento en criterios que afecten al régimen de su utilización para la investigación. 2.1. Clasificación de las muestras atendiendo a la posible identificación de su origen. 2.2. Otros tipos relevantes de clasificaciones de muestras clínicas. 3. Consentimiento informado en materia sanitaria y consentimiento para la utilización de datos personales. 3.1. Normas que aparentemente regulan la utilización de muestras para la docencia y la investigación. 3.2. Sentido y funcionalidad del consentimiento informado. 3.3. Remisión a la protección a la intimidad. 4. Algunas cuestiones jurídicas previas en orden a la determinación de…
Políticas de acceso abierto a la ciencia en las universidades españolas
2013
El objetivo del artículo es analizar el estado de la cuestión de las políticas en favor del acceso abierto (OA) a la ciencia en las universidades españolas. Para ello se han establecido cinco grandes mecanismos de intervención (la creación de infraestructuras y prestación de servicios, la comunicación y difusión, la incentivación económica, la coordinación institucional así como la reglamentación u obligación) que permiten llevar a cabo políticas a favor del acceso abierto y que hemos utilizado para el análisis y la valoración de la situación. La recogida de datos se ha basado en un cuestionario enviado a los vice-rectores de investigación y se ha complementado con la consulta de directorio…
Using Crowdsourcing to Overcome Barriers to Women Entrepreneurship
2015
This chapter presents crowdsourcing as a novel way of overcoming barriers facing women entrepreneurs, offering alternatives to conventional solutions. The study analyzes three barriers to women entrepreneurship: access to financing, access to specific management knowledge, and access to information and communication technologies (ICTs). For each barrier, a different form of crowdsourcing is proposed: crowdfunding, crowd wisdom, and crowdfunded media, respectively. Using these crowdsourcing tools, women entrepreneurs can overcome major difficulties when starting businesses.
Impacto de la Sociedad del Conocimiento en la universidad y en la comunicación científica
2014
A la largo de las dos últimas décadas y como resultado de la introducción y uso intensivo de las tecnologías de la información y del conocimiento en general y de internet en particular, la universidad esta viviendo un proceso de transformación complejo que afecta a sus estructuras académicas y organizativas así como también a su concepción de metodología docente. Las TIC han evidenciado la necesidad de establecer estrategias de coherencia institucional en su uso y aplicación, así como la posibilidad de ampliar los ámbitos de acción institucional y el acceso masivo a la formación superior. Y todo ello pone de manifiesto el cambio existente de un modelo de formación basado en la transmisión d…
Power and language in a multicultural workplace
2015
Today’s work markets are increasingly shaped by the multilingual reality. The present research offers an intercultural communication perspective on language diversity and power relations at modern work environment. Study investigates how young professionals and their foreign colleagues perceive diversity affecting in their communicative behaviours in culturally heterogeneous workplace. Analysis of data from participants has been conducted through an analysis of open ended self‐report questionnaire in a multinational company where English is used daily as a corporate language. In particular, results of present study indicate that more diverse language skills are attributed to perception of p…
The self-perceived commitment and relationship maintenance behaviors among Finnish-Chinese couples in Finland : an application of the investment mode…
2015
The investment model (2003) has been widely used in romantic relationship studies but rarely in an intercultural context. This study tests the investment model by examining Finnish-Chinese couples’ self-perceptions of commitment level and relationship maintenance behaviors. A qualitative research method with deductive thematic analysis approach is applied. This study finds that Finnish-Chinese couples have relatively high level of commitment. They tend to remain in their relationships, to actively derogate alternatives, to sacrifice self-welfare for gratifying relationship well-being, to perceive their relationships as good and healthy and to choose relationship constructive responses under…
Il contratto collettivo aziendale in una prospettiva comparata. Italia, Francia, Spagna e Stati Uniti a confronto
2014
Sulla scorta del metodo comparato, la tesi analizza le recenti modifiche alla disciplina del contratto collettivo aziendale in Italia, Francia e Spagna, introdotte dalla legge e dagli accordi interconfederali; l'obiettivo è dimostrare un tendenziale avvicinamento degli stati europei analizzati al sistema nord-americano di relazioni industriali, in cui il rapporto di lavoro è regolato non tanto dalla legge o dall'accordo di categoria, ma dal contratto aziendale.Vengono inoltre analizzati i recenti accordi collettivi firmati alla Fiat ed alla Chrysler a partire dal processo di integrazione iniziato nel 2009. According to the comparative method, the thesis analyses the recent changes to the di…
Jeux et enjeux du paraître lors de l'entrée en cours préparatoire et de l'entrée en sixième
1993
International audience
Assisted baseline subtraction in complex chromatograms using the BEADS algorithm.
2017
The data processing step of complex signals in high-performance liquid chromatography may constitute a bottleneck to obtain significant information from chromatograms. Data pre-processing should be preferably done with little (or no) user supervision, for a maximal benefit and highest speed. In this work, a tool for the configuration of a state-of-the-art baseline subtraction algorithm, called BEADS (Baseline Estimation And Denoising using Sparsity) is developed and verified. A quality criterion based on the measurement of the autocorrelation level was designed to select the most suitable working parameters to obtain the best baseline. The use of a log transformation of the signal attenuate…