Search results for "relationship"

The Digitalisation of Political Parties in Comparative Perspective

2021

This chapter outlines the main findings of the edited book. Through the study of a wide range of political parties from Europe and beyond, this book has explored the different degrees of digitalisation that political parties present, and, at the same time, discussed the main technological, democratic issues and trade-offs that political parties have faced in their digital transition. The most relevant finding is that all political parties operating in the democracies analysed have digitalised their organisations to some extent. Our main finding across several cases shows that the digitalisation of parties does not entail a homogenous process of convergence towards a new mode of managing par…

TBBPA causes neurotoxic and the apoptotic responses in cultured mouse hippocampal neurons in vitro

2015

Abstract Background Tetrabromobisphenol A (TBBPA) is a brominated flame retardant widely used in a variety of commercial and household products. TBBPA can become bioaccumulated in human body fluids, and also in different brain regions. The aim of the present study was to determine the viability and apoptosis of cultured mouse hippocampal neurons in vitro after exposure to TBBPA. Additionally, we examined the involvement of ROS generation in the effect of TBBPA. Methods Primary hippocampal neuron cultures were prepared from Swiss mouse embryos on day 17/18 of gestation. The cultures were treated with TBBPA at concentrations ranging from 1 nM to 100 μM for 30 min or 3, 6 or 24 h. To study apo…

Emil Fischer—Unequalled Classicist, Master of Organic Chemistry Research, and Inspired Trailblazer of Biological Chemistry

2002

Polypeptoid-block-polypeptide Copolymers: Synthesis, Characterization, and Application of Amphiphilic Block Copolypept(o)ides in Drug Formulations an…

2013

We report the synthesis of polysarcosine-block-polyglutamic acid benzylester (PSar-block-PGlu(OBn)) and polysarcosine-block-polylysine-ε-N-benzyloxycarbonyl (PSar-block-PLys(Z)) copolymers. The novel polypeptoid-block-polypeptide copolymers (Copolypept(o)ides) have been synthesized by ring-opening polymerization (ROP) of N-carboxyanhydrides (NCAs). Polymerization conditions were optimized regarding protecting groups, block sequence and length. While the degree of polymerization of the PSar block length was set to be around 200 or 400, PGlu(OBn) and PLys(Z) block lengths were varied between 20 to 75. The obtained block copolymers had a total degree of polymerization of 220-475 and dispersity…

Supramolecular Assemblies Based on Complexes of Nonionic Amphiphilic Cyclodextrins and a meso-Tetra(4- sulfonatophenyl)porphine Tributyltin(IV) Deriv…

2013

Amphiphilic cyclodextrin (ACyD) provides water-soluble and adaptable nanovectors by modulating the balance between the hydrophobic and hydrophilic chains at both CyD sides. This work aimed to design nanoassemblies based on nonionic and hydrophilic ACyD (SC6OH) for the delivery of a poor-water-soluble organotin(IV)-porphyrin derivative [(Bu3Sn)4TPPS] to melanoma cancer cells. To characterize the porphyrin derivatives under simulated physiological conditions, a speciation was performed using complementary techniques. In aqueous solution (≤ 20 μM), (Bu3Sn)4TPPS primarily exists as a monomer (2 in Figure 1), as suggested by the low static anisotropy (ρ ≈ 0.02) with a negligible formation of por…

Missing the rarest: is the positive interspecific abundance–distribution relationship a truly general macroecological pattern?

2009

Lepidopterists have long acknowledged that many uncommon butterfly species can be extremely abundant in suitable locations. If this is generally true, it contradicts the general macroecological pattern of the positive interspecific relationship between abundance and distribution, i.e. locally abundant species are often geographically more widespread than locally rare species. Indeed, a negative abundance–distribution relationship has been documented for butterflies in Finland. Here we show, using the Finnish butterflies as an example, that a positive abundance–distribution relationship results if the geographically restricted species are missed, as may be the case in studies based on random…

l-Glutamate receptor binding in bovine retina

1982

Using a centrifugation technique saturable specific [ 3 H]glutamate binding in bovine retina could be demonstrated. Scatchard analysis revealed only one population of binding sites with a dissociation constant of about 3 μ m and a maximal number of binding sites of about 0·2 pmol/mg retinal protein. Several glutamic acid analogues inhibit specific [ 3 H]glutamate binding in bovine retina with half-maximal inhibitory concentrations similar to those reported in other areas of the CNS. Specific [ 3 H]glutamate binding and sodium dependent synaptosomal uptake of glutamate are largely concentrated in the P2 fraction of bovine retina homogenates consisting of conventionally sized synaptosomes. Th…

Estrategias ante el uso de Internet por población usuaria en Atención Primaria: una clasificación sociológica

2021

Resumen: Objetivo: Analizar y clasificar las estrategias comunicativas que desarrollan los/las profesionales de atención primaria de salud de la Comunitat Valenciana ante el uso de Internet como fuente de información de salud por parte de la población usuaria, a través de las categorías analíticas de poder y control que, según Basil Bernstein, caracterizan los procesos de comunicación de los encuentros terapéuticos. Método: Estudio cualitativo mediante entrevistas en profundidad a profesionales de atención primaria de salud de la Comunitat Valenciana (n = 18). Para el análisis de los discursos se ha aplicado el lenguaje de descripción de la teoría de Bernstein con el objetivo de clasificar …

Quasi-brittle porous material: Simulated effect of stochastic air void structure on compressive strength

2021

Abstract The effect of porosity comprised of spherical air voids on the compressive strength of quasi-brittle material was studied via simulations. The simulated porous structures were based on pore size distributions of two mortar samples measured by X-ray microtomography. While the simulation method set practical limits on the size of sample, the base of the statistics was established by simulating 128 small structures generated by sampling from pore structures of two mortars. By studying the application of the classical strength-porosity formulas to the simulated data, a new simple model was formed. A linear relationship was achieved between the cubic root of air void fraction (porosity)…

Sports participation and cultural trends. Running as a reflection of individualisation and post-materialism processes in Spanish society

2014

AbstractThis article examines the relationship between cultural change processes and the practice of running. The empirical basis is the national survey on Spanish sport habits carried out in 2005. Specifically, the subsamples of runners (n = 343) and other sport modalities (n = 2,687) were used. The study reveals that runners are characterised by more post-materialist and individualist tendencies than the rest of the participants. The results suggest the existence of a close relationship between the predominant cultural orientations and certain types of sport activity.