Search results for "relationship"
showing 10 items of 3616 documents
How Does Tyrosinase Work? Recent Insights from Model Chemistry and Structural Biology
2000
ChemInform Abstract: How Does Tyrosinase Work? Recent Insights from Model Chemistry and Structural Biology
2010
Prediction of perception using structure–activity models
2016
IntroductionThe possible link between the molecular structure and a biological activity was pointed out by Linus Pauling (1946) just before the middle of the 20th century. Nevertheless, this concept has been already suggested a century before by Emil Fisher and “lock-and-key” theory: “To use a metaphor, I would say that enzyme and glucoside are such lock and key that fit together in order to exert a reciprocal chemical effect on each other”a (Fischer, 1894). The notion that the biological properties of a compound would be a function of its chemical characteristics is now well admitted, and is closely linked to that of pharmacophore. The pharmacophore concept is related to the interaction of…
New perspective of learner-centered education in nowadays didactics
2017
An approach to education that is based on the educational context in which the student comes and track progress in achieving the learning objectives. The learner-centred education learning places the responsibility on the shoulders of students, while the teacher takes responsibility for facilitating the education process. The approach tends to be unique, flexible, competency-based methodology and not always varied in time and space constrained. Teaching will have complex changes, so if, traditionally, it is just a business communication / transmission of knowledge, actual perspectives follows specifically aims in organizing and managing learning processes. According to the researchers in th…
Opposing Forces of Social Attraction and Social Avoidance Drive Network Modularity
2020
SUMMARY: How interactions between individuals contribute to the emergence of complex societies is a major question in biology. Nonetheless, little remains known about how simple rules of social attraction (e.g. to information) and social avoidance (e.g. of disease) interact to shape sociality. We developed an individual-based model where individuals choose with whom to interact depending on the status of group mates (informed and/or infected). Statistical models indicate that the emergence of social structure depends on the cost/benefit trade-offs underlying the system. Critically, pressures that optimize social relationships – i.e. minimize risky connections while favouring those that maxi…
To Hit or Not to Hit, That Is the Question - Genome-wide Structure-Based Druggability Predictions for Pseudomonas aeruginosa Proteins.
2015
Pseudomonas aeruginosa is a Gram-negative bacterium known to cause opportunistic infections in immune-compromised or immunosuppressed individuals that often prove fatal. New drugs to combat this organism are therefore sought after. To this end, we subjected the gene products of predicted perturbative genes to structure-based druggability predictions using DrugPred. Making this approach suitable for large-scale predictions required the introduction of new methods for calculation of descriptors, development of a workflow to identify suitable pockets in homologous proteins and establishment of criteria to obtain valid druggability predictions based on homologs. We were able to identify 29 pert…
School adjustment in children who stutter: The quality of the student-teacher relationship, peer relationships, and children's academic and behaviora…
2020
Abstract Introduction The aim of this study was to investigate the quality of the student-teacher relationship, peer relationship, emotional and behavioral outcomes and academic performance in school adjustment of children who stutter. Methods The convenience sample consisted of 536 children – 62 affected by stuttering and 474 in the control group – and 36 prevalent teachers from six primary and secondary schools in Northwest Italy. Children were assessed with a sociometric questionnaire. Teacher evaluations were also used to assess their perception of their relationships with the student (Student-Teacher Relationship Scale), children’ behavior (Strengths and Difficulties Questionnaire), an…
Bullying in Students Who Stutter: The Role of the Quality of the Student–Teacher Relationship and Student’s Social Status in the Peer Group
2020
Children who stutter are at risk of being excluded, rejected, or bullied at school because of their impairment. The aim of the current research is to assess the relationship between students and te...
Changes in the cerebrovascular effects of endothelin-1 and nicardipine after experimental subarachnoid hemorrhage.
1993
The role of endothelium-related factors in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH) has gained interest since the discovery of endothelin-1 (ET-1). We have examined, before and after SAH, the responsiveness of the cerebrovascular bed of the goat to ET-1, the sources of Ca2+ in ET-1-induced responses, and the ability of the Ca2+ entry blocker nicardipine to counteract them. Before SAH, injection of ET-1 into the cerebral circulation increased cerebrovascular resistance, thereby producing dose-dependent reductions in cerebral blood flow (CBF), which were prevented by nicardipine. In isolated middle cerebral arteries, ET-1 induced concentration-dependent contr…
Acid- and Base-Catalysis in the Mononuclear Rearrangement of Some (Z)-arylhydrazones of 5-Amino-3-benzoyl-1,2,4-oxadiazole in Toluene: Effect of Subs…
2011
The reaction rates for the rearrangement of eleven (Z)-arylhydrazones of 5-amino-3-benzoyl-1,2,4-oxadiazole 3a-k into the relevant (2-aryl-5-phenyl-2H-1, 2,3-triazol-4-yl)ureas 4a-k in the presence of trichloroacetic acid or of piperidine have been determined in toluene at 313.1 K. The results have been related to the effect of the aryl substituent by using Hammett and/or Ingold-Yukawa-Tsuno correlations and have been compared with those previously collected in a protic polar solvent (dioxane/water) as well as with those on the analogous rearrangement of the corresponding (Z)-arylhydrazones of 3-benzoyl-5-phenyl-1,2,4-oxadiazole 1a-k in benzene. Some light can thus be shed on the general di…