Search results for "removal"
showing 10 items of 316 documents
Current insights into the German lipoprotein apheresis standard: PCSK9-inhibitors, lipoprotein apheresis or both?
2017
Abstract According to current European guidelines, lipid lowering therapy for progressive cardiovascular disease including cardiovascular events has to be focused on a target level for LDL-C. In contrast for Lp(a) a threshold has to be defined with respect to the method of measurement. However, due to new lipid lowering drug developments like PCSK9-inhibitors (PCSK-9-I) a therapeutic algorithm for patients with severe hypercholesterolemia or isolated Lipoprotein(a)-hyperlipoproteinemia with progressive cardiovascular disease may be necessary to manage the use of PCSK9-I, lipoprotein apheresis (LA) or both. The therapeutic approach for patients with homozygous familial hypercholesterolemia i…
Long-term efficacy of lipoprotein apheresis and lomitapide in the treatment of homozygous familial hypercholesterolemia (HoFH): a cross-national retr…
2021
Abstract Background Homozygous familial hypercholesterolemia (HoFH) is a rare life-threatening condition that represents a therapeutic challenge. The vast majority of HoFH patients fail to achieve LDL-C targets when treated with the standard protocol, which associates maximally tolerated dose of lipid-lowering medications with lipoprotein apheresis (LA). Lomitapide is an emerging therapy in HoFH, but its place in the treatment algorithm is disputed because a comparison of its long-term efficacy versus LA in reducing LDL-C burden is not available. We assessed changes in long-term LDL-C burden and goals achievement in two independent HoFH patients’ cohorts, one treated with lomitapide in Ita…
Diagnostic and clinical procedures of a patient with oral-facial-digital type II syndrome: a case report
2011
The oral-facial-digital syndromes (OFD) are part of a great number of genetic disorders. They are classified in categories based on characteristic abnormalities, including OFD type I (Papillon-Leage and Psaume syndrome) and OFD type II (Mohr syndrome). The aim of this article is to describe a clinical case of a patient with oral- facial-digital type II syndrome or Mohr syndrome, who underwent surgery for supernumerary teeth removal under endovenous sedation. Moreover, it is intended to discuss the importance of diagnostic and clinical procedures, with proper and concise indications about the limitations of patients with special needs treatment. Due to their clinical and physiological limita…
The history of meniscal-surgery
2000
In comparison with other operative procedures, the history of meniscal-surgery offers some particular differences. Over a long period of time injuries of the semilunar-cartilages of the knee-joint were not generally recognised. In the 18th century only was the clinical picture roughly outlined. There is evidence, that parts of the meniscus were removed much earlier than we have historic proof of. These meniscal fragments were generally mistaken for "loose bodies" in the joints, not knowing the exact etiology. Operative interference with joints was afflicted with a very high incidence of infections and thus complications. Due to this reliable standards of sterility were imperative to obtain …
Antithrombotic therapy of Cerebral cavernous malformations
2020
Abstract Cavernous malformations are recognized as the most common vascular anomalies in the brain, that often lead to hemorrhage with neurological symptoms. Usually the treatment is surgical removal or stereotactic radiotherapy. We present a case of a slow-flow vascular anomaly located in the cavernous sinus with recurrent partial thrombotic areas. Inspired by treatment of peripheral venous anomalies antithrombotic therapy was initiated instead of surgery or stereotactic radiotherapy. This led to complete spontaneous resolution of the lesion and normalization of symptoms within nine months. The patient never showed any symptoms over a period of eight years while continuing antithrombotic t…
Clinical retrospective study of dental implant removal : do patients who require implant removal desire implant prosthesis again?
2020
Background This study investigated the causes of dental implant removal due to complications, and examined whether patients who had dental implant removal desired re-implant prosthesis treatments. Material and Methods A retrospective case–control study was conducted on patients who had their dental implants removed. We investigated whether the removed dental implant was replaced with other implant prostheses. Age, sex, diabetes, smoking, implant site distribution, reason for implant removal, and blade and root-form implants were categorized as predictive variables. The outcome variable was desire for re-implantation or use of other prosthetic methods after implant removal. A logistic regres…
Longitudinal metagenomics
2018
Culture-independent approaches are revolutionizing biology. Whether in a clinical or in an environmental sample, metagenomics can reveal which microorganisms exist and what they actually do. Metagenomic studies have unveiled more microbial diversity in a few years than traditional microbiology in centuries. From the top branches down to the roots, its discoveries are reshaping the tree of life dramatically. Metagenomics is a powerful tool for the study of microbial communities, but it requires equally powerful methods of analysis. Current challenges in the analysis of metagenomic data include the accurate comparison of samples, the estimation of the uncertainty in the results, and the effec…
EFFECT OF IONIC STRENGTH AND MEDIUM COMPOSITION ON THE REMOVAL OF Pb2+ BY ALGINATE GEL BEADS. DPVASV AND ICP-OES MEASUREMENTS.
2012
The biosorption, i.e. a passive sequestering process by metabolically inactive biomass, shows a growing interest for toxic metal ions removal from contaminated aqueous solutions (1), such as municipal and industrial wastewaters. Since the sorption mechanism occurs mainly by ion exchange between the metal ion present in solution and the counter ion of the biopolymer (2), the efficiency of the sorption process largely depends on ionic strength and on the medium composition of solution containing the metal ion to be removed. In order to evaluate quantitatively the influence of ionic strength and medium on the metal removal process by the biomass, we report here results of a study on the sorpti…
Modelling biological nitrogen and phosphorus removal with soluble microbial products (SMP) production-degradation processes
2011
Over the last two decades, Membrane Bioreactors (MBR) are increasingly used for wastewater treatment. Mathematical modelling of MBR systems has played a key role in order to better explain the effect of their peculiarities. Indeed, several MBR models have been presented in literature in order to improve the knowledge on MBR systems: biological models, hybrid models which include soluble microbial product (SMP) modelling, physical models able to describe the membrane fouling and integrated models which couple the hybrid models with the physical ones. However, among the existing MBR models only few integrated models have been developed which take into account the existing relationship between…
Removal of silicon from CFB-derived fly ash leachate in the context of phosphorus recovery
2018
High concentrations of dissolved silica in the acid leachate impose two major challenges on precipitation based recovery of phosphorus (P). Firstly, co-precipitation of colloidal silica in the acidic regimes decreases the purity and value of precipitated P-products. In addition, silica scaling on internal surfaces of equipment is also a problematic issue in industrial operations. Therefore, removal of dissolved silica prior to P-recovery process minimizes the risks of Si-contamination in P-products and Si-scaling. In the present study, silica removal was achieved by accelerated silica polymerization with higher acidity and ionic strength of mineral acid, which also assisted the leaching of …