Search results for "renal"
showing 10 items of 1828 documents
"Det pirrar inte i magen" : Einstellungen von Deutsch- und Schwedisch lernenden finnischen Senioren zum Sprechen und zur mündlichen Sprachkompetenz
2014
Työn tarkoituksena oli selvittää, miten yli 60-vuotiaat saksan ja ruotsin oppijat suhtautuvat vieraan kielen puhumiseen. Kokemukseni mukaan vanhemmat kielenoppijat keskittyvät suullisen ja kommunikatiivisen kielitaidon sijasta eniten kielen kirjalliseen muotoon. Tämän lisäksi suurin osa vanhemmista kielenoppijoista on aloittanut kieliopintonsa kielioppi-käännös-menetelmän aikana, jolloin suulliseen kielitaitoon ei kiinnitetty juurikaan huomiota. Koska nykyään suullinen kielitaito on pääosassa koulujen kielenopetuksessa, halusin tutkimuksen avulla myös selvittää, mikä puhetaidon asema on kansalaisopistossa opiskelevien ikääntyvien kielenoppijoiden mielestä suhteessa kielitaidon muihin osa-al…
Genetic profile and immunohistochemical study of clear cell renal carcinoma: Pathological-anatomical correlation and prognosis.
2021
Abstract Introduction Renal cell carcinoma (RCC) accounts for 2–3% of all tumors being the most frequent solid lesion in the kidney. Objective To determine what genetic alterations and immunohistochemical (IHC) of clear cell renal carcinoma (ccRCC) are associated with prognosis and tumor aggressiveness. Patients and Methods Experimental analytical study with 57 patients who underwent radical and partial nephrectomy between 2005 and 2011, all with diagnosis of ccRCC and minimum post-operative follow-up of 36 months. The pathological study included IHC determination of biomarkers associated (CAIX, CAM 5.2, CD10, c-erbB-2, EGFR, HIF-1a, Ki67, MDM2, PAX-2 y 8, p53, survivin and VEGFR 1 and 2). …
Hypothalamic-Pituitary-Adrenal axis and cognitive function in healthy older people: genetic, situational and individual factors
2019
The world population is getting older, and this age group faces important health challenges, among which age-related cognitive decline stands out. Therefore, it is important to identify vulnerability and protective health factors in order to understand ways to prevent cognitive decline. This thesis aimed to address the relationship between the Hypothalamic–Pituitary–Adrenal (HPA) axis and cognitive functioning during aging, taking into account genetic (Apolipoprotein E, ApoE, polymorphism), situational (loneliness), and individual factors (personality traits). To do this, a group of healthy older people over 55 years of age, men and women, were evaluated. A neuropsychological battery was ad…
Feasible Low-Phosphorus Dietary Patterns in Maintenance Hemodialysis Patients: Need for Original Research
2020
Introduction The standard low-phosphorus diet restricts pulses, nuts, and whole grains and other high phosphorus foods to control hyperphosphatemia. We conducted a randomized controlled trial to evaluate the effectiveness, safety, and tolerability of the modified diet, which introduced some pulses and nuts, increased the use of whole grains, increased focus on the avoidance of phosphate additives, and introduced the prescription of low-biological-value protein such as bread. Methods We conducted a multicenter, pragmatic, parallel-arm, open-label, randomized controlled trial of modified versus standard diet in 74 adults on hemodialysis with hyperphosphatemia over 1 month. Biochemistry was as…
Análisis proteómico no dirigido en pacientes con shock séptico y fracaso renal agudo (PROTEOSEP)
2022
La sepsis es una de las patologías más frecuentes y la primera causa de muerte en las Unidades de Cuidados Intensivos, siendo el shock séptico su forma más grave de presentación. En la actualidad la sepsis constituye un problema de salud importante por su elevada mortalidad empeorando el pronóstico cuando asocia una lesión renal aguda. El diagnóstico precoz y la aplicación inmediata de un tratamiento adecuado han demostrado ser esenciales para frenar el fallo multiorgánico y reducir la mortalidad. Aunque se ha avanzado en el conocimiento de la fisiopatología de la sepsis, la identificación de biomarcadores para guiar terapias farmacológicas eficaces sigue siendo un desafío, debido fundament…
external iliac artery pseudoaneurysm complicating renal transplantation
2008
Antitumor Effect of Cabozantinib in Bone Metastatic Models of Renal Cell Carcinoma
2021
Background: The presence of bone metastases in renal cell carcinoma (RCC) negatively affects patients’ survival. Data from clinical trials has highlighted a significant benefit of cabozantinib in bone metastatic RCC patients. Here, we evaluated the antitumor effect of cabozantinib in coculture models of renal cell carcinoma (RCC) and osteoblasts (OBs) to investigate whether and how its antiproliferative activity is influenced by OBs. Methods: Bone/RCC models were generated, coculturing green fluorescent protein (GFP)-tagged Caki-1 and 786-O cells with human primary OBs in a “cell–cell contact” system. RCC proliferation and the OB molecular profile were evaluated after the cabozantinib treat…
Nieru audzēju klīniski morfoloģiskais raksturojums
2020
Saslimstība ar ļaundabīgajiem nieru audzējiem palielinās katru gadu, visizteiktāk tas vērojams pasaules attīstītajās valstīs, kā arī Latvijā. Nieru šūnu karcinoma ir viens no visbiežākajiem ļaundabīgajiem nieru audzējiem. Agrīnajās stadijās nieru šūnu karcinomai nav raksturīga kāda konkrēta simptomātika un lielākajā daļā gadījumu, tā tiek diagnosticēta netīši- veicot izmeklējumus kādas citas saslimšanas gadījumā. Pēc tam, kad audzējs ir ticis diagnosticēts, ir būtiski izvērtēt pacienta vispārējo stāvokli un riska faktorus, no kā ir atkarīga pacientu kopējā dzīvildze un recidīva risks. Ja iespējams, noteikt histoloģisko nieru šūnu karcinomas subtipu un ņemot vērā šos faktorus, izvēlēties pie…
Kinetics of Renal Function during Induction in Newly Diagnosed Multiple Myeloma: Results of Two Prospective Studies by the German Myeloma Study Group…
2021
Background: Preservation of kidney function in newly diagnosed (ND) multiple myeloma (MM) helps to prevent excess toxicity. Patients (pts) from two prospective trials were analyzed, provided postinduction (PInd) restaging was performed. Pts received three cycles with bortezomib (btz), cyclophosphamide, and dexamethasone (dex
EtG Quantification in Hair and Different Reference Cut-Offs in Relation to Various Pathologies: A Scoping Review
2022
Ethyl glucuronide (EtG) is a non-volatile, non-oxidative, hydrophilic, and stable ethanol phase II metabolite. EtG is produced through ethanol glucuronidation by UDP-glucuronosyltransferase (UGT), a phase II enzyme. EtG can be extracted from different biological matrices, including keratin ones, such as hair or nails. The purpose of this scoping review is to describe the relationship between EtG levels in hair and some of the most common and frequent pathological conditions and verify whether different reference cut-offs in relation to various pathologies have been identified in the scientific literature. In fact, in-depth knowledge of the influence of pathologies, such as diabetes mellitus…