Search results for "resolution"
showing 10 items of 1928 documents
Cylindrical Cell-Based Refractometers to Analyse Biomedical Liquids
2015
Compact device of high sensitivity for measurement of the refractive indices of both stationary and flowing liquids has been developed. This device can be used to analyse a variety of biomedical liquids: urine, serum protein. The refractive index (RI) is determined by measuring the deviation of a laser beam passing through a cylindrical cell containing the test liquid. In order to significantly improve the resolution and stability of RI measurements, the repeated reflections and refractions of the light beam travelling through the cylindrical cell are employed.
Spatial and spectral properties of small area THz generation for sub-wavelength microscopy
2010
A highly localized THz source is a promising candidate for sub-wavelength microscopy, due to its superior radiation power throughput with respect to others near-field techniques. Here, we report on the spatial and the spectral near-field properties of our highly localized THz source.
Real-space imaging and motion analysis in sheared colloidal crystals
2007
Microscopic imaging of single particles is a powerful tool to investigate the local structure of colloidal suspensions. For single-particle identification with high-resolution microscopy the resolution power is limited by refraction to roughly the wavelength of light. In this case the depth of sharpness is on a scale of less than this limit. For this reason the simultaneous observation of particles in two or more layers of a colloidal crystal seems to be impossible. We report a method with which we can image more than one particle layer in dilute colloidal suspensions with preserved resolution. The analysis of the images obtained, in particular for the investigation of crystal layer motion …
SU-E-I-83: Detectability Limits of a New Positron Emission Mammography in Relation to Tumour-Size, Tumour-To-Background Ratio and Activity Concentrat…
2017
Purpose:Positron emission mammography(PEM) improves spatial resolution and sensitivity, making it suitable for early breast tumours detection. The aim of this study is to evaluate the limits of a dedicated breast PET in terms of tumour‐size, tumour‐to‐background activity concentration ratio (TBR) and activity concentration. Methods: A dedicated PEM is evaluated. To characterize the device, we use a phantom of 15 cm of diameter containing 6 inserts of inner diameters 18, 15, 11, 8, 5 and 3 mm. To evaluate the detectability limits images are acquired by varying the TBR from 10 to 2 and without background activity concentration. In all the studies the activity concentration for the 6 inserts i…
MR-Perfusionsbildgebung des Herzens mit TrueFISP
2001
OBJECTIVE Development and test of a saturation-recovery TrueFISP (SR-Trufi) pulse sequence for myocardial perfusion MR imaging (MRI) using improved gradient hardware. MATERIAL AND METHODS Measurements were performed on a 1.5 T scanner with prototype gradients (50 mT/m, minimum rise time 300 microseconds). T1-weighted first-pass MRI of Gd-DTPA (0.025 mumol/kg) kinetics in the myocardium was performed using an SR-Trufi pulse sequence (TR/TE/alpha = 2.6 ms/1.4 ms/55 degrees) with a saturation preparation of TD = 30 ms before the TrueFISP readout. Measurements were performed in volunteers (n = 4) and in a pig model of chronic ischemia (n = 1). RESULTS In phantoms, the signal intensity was linea…
A comparison of three different micro-tomography systems for accurate determination of microvascular parameters
2008
The investigation of micro-vessel dimensions in 3D is currently problematic due to their complex structures and fine scale. Quantification of vascular parameters is important in several fields of biomedicine; including embryogenesis, wound healing, diseases characterized by uncontrolled angiogenesis (e.g. tumor growth and metastasis) and the development of implantable bio-materials where a functional vascular supply is critical to their successful integration into host tissue. However, techniques that can resolve the micron-scaled features of these capillary beds, such as scanning electron and confocal microscopy, do not allow for total image reconstitution in 3 D in thick tissue samples [1…
Nanographenes: Ultrastable, Switchable, and Bright Probes for Super-Resolution Microscopy.
2019
Abstract Super‐resolution fluorescence microscopy has enabled important breakthroughs in biology and materials science. Implementations such as single‐molecule localization microscopy (SMLM) and minimal emission fluxes (MINFLUX) microscopy in the localization mode exploit fluorophores that blink, i.e., switch on and off, stochastically. Here, we introduce nanographenes, namely large polycyclic aromatic hydrocarbons that can also be regarded as atomically precise graphene quantum dots, as a new class of fluorophores for super‐resolution fluorescence microscopy. Nanographenes exhibit outstanding photophysical properties: intrinsic blinking even in air, excellent fluorescence recovery, and sta…
A new approach for actinic defect inspection of EUVL multilayer mask blanks: Standing wave photoemission electron microscopy
2006
Extreme ultraviolet lithography (EUVL) at 13.5 nm is the next generation lithography technique capable of printing sub-50 nm structures. With decreasing feature sizes to be printed, the requirements for the lithography mask also become more stringent in terms of defect sizes and densities that are still acceptable and the development of lithography optics has to go along with the development of new mask defect inspection techniques that are fast and offer high resolution (preferable in the range of the minimum feature size) at the same time. We report on the development and experimental results of a new 'at wavelength' full-field imaging technique for defect inspection of multilayer mask bl…
Characterization of a pulsed injection-locked Ti:sapphire laser and its application to high resolution resonance ionization spectroscopy of copper
2017
A high repetition rate pulsed Ti:sapphire laser injection-locked to a continuous wave seed source is presented. A spectral linewidth of 20 MHz at an average output power of 4W is demonstrated. An enhanced tuning range from 710-920 nm with a single broadband mirror set is realized by the inclusion of a single thin birefringent quartz plate for suppression of unseeded emission. The spectral properties have been analyzed using both a scanning Fabry-P´erot interferometer as well as crossed beam resonance ionization spectroscopy of the hyperfine levels of natural copper. Delayed ionization of the long-lived excited state is demonstrated for increased resolution. For the excited state hyperfine c…
Fundamentals of the design and the operation of an intelligent tutoring system for the learning of the arithmetical and algebraic way of solving word…
2013
Designers of interactive learning environments with a focus on word problem solving usually have to compromise between the amount of resolution paths that a user is allowed to follow and the quality of the feedback provided. We have built an intelligent tutoring system (ITS) that is able to both track the user's actions and provide adequate supervision during the resolution. This is done without imposing any restriction on the resolution paths that are allowed. Instead, the system attempts to enforce metacognitive learning by requiring an appropriate definition of quantities before they are used. The program (a) supports both the arithmetical and algebraic way of solving problems; (b) allow…