Search results for "respiratory function"

showing 10 items of 175 documents

Circadian rhythm of COPD symptoms in clinically based phenotypes. Results from the STORICO Italian observational study

2019

Abstract Background Chronic Obstructive Pulmonary Disease (COPD) encompasses various phenotypes that severely limit the applicability of precision respiratory medicine. The present investigation is aimed to assess the circadian rhythm of symptoms in pre-defined clinical COPD phenotypes and its association with health-related quality of life (HR-QoL), the quality of sleep and the level of depression/anxiety in each clinical phenotype. Methods The STORICO (NCT03105999) Italian observational prospective cohort study enrolled COPD subjects. A clinical diagnosis of either chronic bronchitis (CB), emphysema (EM) or mixed COPD-asthma (MCA) phenotype was made by clinicians at enrollment. Baseline e…

MaleChronic bronchitisTime FactorsHealth StatusAnxietyHospital Anxiety and Depression ScaleSeverity of Illness IndexHealth StatuPulmonary Disease Chronic Obstructive0302 clinical medicineSurveys and QuestionnairesForced Expiratory VolumeClinical phenotypeMedicineSurveys and QuestionnaireRespiratory function030212 general & internal medicineProspective StudiesProspective cohort studyLungDepression (differential diagnoses)COPDDepressionMiddle AgedCircadian RhythmPhenotypeItalyAnxietyFemalemedicine.symptom24-hour symptoms Clinical phenotype Real-world Respiratory functionResearch ArticleHumanPulmonary and Respiratory Medicinemedicine.medical_specialtyChronic ObstructiveTime FactorSettore MED/10 - Malattie Dell'Apparato RespiratorioPulmonary Disease03 medical and health sciencesInternal medicineHumansAsthma24-hour symptoms; Clinical phenotype; Real-world; Respiratory function; Aged; Anxiety; Depression; Female; Forced Expiratory Volume; Health Status; Humans; Italy; Lung; Male; Middle Aged; Phenotype; Prospective Studies; Pulmonary Disease Chronic Obstructive; Severity of Illness Index; Sleep; Surveys and Questionnaires; Time Factors; Circadian Rhythm; Quality of LifeAgedlcsh:RC705-77924-hour symptomsbusiness.industryCorrectionlcsh:Diseases of the respiratory systemmedicine.disease24-hour symptomProspective Studie030228 respiratory systemReal-worldQuality of LifebusinessSleepRespiratory function
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Dental state and functional capacity in 75-year-olds in three Nordic localities

1995

summary The aims of the study were to compare dental state in three Nordic 75-year-old populations and to evaluate dental state as a marker of functional ageing. The study is part of a Nordic comparative study of 75-year-olds in Glostrup, Goteborg and Jyvaskyla. In the dental studies, 411 subjects in Denmark, 308 in Sweden and 310 in Finland participated. Odontological history was obtained from interviews. Other methods, which are described elsewhere, were used to measure various functional parameters. In Goteborg, 23% of the 75-year-olds reported they were edentulous and 27% that they had more than 20 of their own teeth. The corresponding figures in Glostrup were 45% and 15% and in Jyvasky…

MaleGerontologySpirometryAgingHealth StatusPhysical activityScandinavian and Nordic CountriesStatistics NonparametricTooth Lossstomatognathic systemResidence CharacteristicsPrevalencemedicineHumansDental CareDental Health SurveysGeriatric AssessmentGeneral DentistryAgedmedicine.diagnostic_testbusiness.industryDental healthSocial activitySmokingRespiratory Function Testsstomatognathic diseasesLogistic ModelsLifestyle factorsSocioeconomic FactorsLinear ModelsFemalebusinessJournal of Oral Rehabilitation
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Chronic bronchitis without airflow obstruction, asthma and rhinitis are differently associated with cardiovascular risk factors and diseases

2019

Background and objectives Cardiovascular and respiratory diseases can frequently coexist. Understanding their link may improve disease management. We aimed at assessing the associations of chronic bronchitis (CB), asthma and rhinitis with cardiovascular diseases and risk factors in the general population. Methods We used data collected in the Gene Environment Interactions in Respiratory Diseases study, an Italian multicentre, multicase-control study. Among 2463 participants (age 21–86, female 50%) who underwent standardized interviews, skin prick and lung function tests, we identified 254 cases of CB without airflow obstruction, 418 cases of asthma without CB, 959 cases of rhinitis alone, a…

MaleLUNG-DISEASEChronic bronchitisPulmonologyEpidemiologyBlood PressureCardiovascular Medicine030204 cardiovascular system & hematologyVascular Medicine[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tractCohort StudiesPulmonary Disease Chronic Obstructive0302 clinical medicineRisk FactorsMedicine and Health SciencesOdds Ratiochronic bronchitiLungRhinitisAged 80 and overeducation.field_of_studyAlcohol ConsumptionMultidisciplinaryQRHeartMiddle AgedCardiovascular diseaseCBRespiratory Function Tests3. Good healthPREVALENCE[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemBronchitis ChronicALLERGIC RHINITISINTERMITTENT CLAUDICATIONCardiovascular DiseasesHypertensionBronchitisMedicinechronic bronchitisFemaleAnatomymedicine.symptomResearch ArticleAdultmedicine.medical_specialtySciencePopulationbody mass indexSettore MED/10 - Malattie Dell'Apparato RespiratorioDIAGNOSISelderlychronic obstructive pulmonary diseaseYoung Adult03 medical and health sciencesHeart disorderBMI[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemInternal medicineConfidence IntervalsmedicineHumansCOPDCORONARY-HEART-DISEASEBronchitiseducationNutritionAgedAsthmaCORONARY-HEART-DISEASE; ALLERGIC RHINITIS; INTERMITTENT CLAUDICATION; MYOCARDIAL-INFARCTION; MUCUS HYPERSECRETION; CIGARETTE-SMOKING; LUNG-DISEASE; DIAGNOSIS; ATHEROSCLEROSIS; PREVALENCEbusiness.industryBiology and Life SciencesOdds ratioRhinologyasthmamedicine.diseaseIntermittent claudicationDietOtorhinolaryngology030228 respiratory systemMYOCARDIAL-INFARCTIONATHEROSCLEROSISMUCUS HYPERSECRETION[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologieMedical Risk FactorsCase-Control StudiesRelative riskNasal DiseasesCardiovascular Anatomy[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologieCIGARETTE-SMOKINGbusinessBMI body mass index; CB chronic bronchitis; COPD chronic obstructive pulmonary disease;
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Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol…

2017

Background Postoperative pulmonary complications (PPCs) increase the morbidity and mortality of surgery in obese patients. High levels of positive end-expiratory pressure (PEEP) with lung recruitment maneuvers may improve intraoperative respiratory function, but they can also compromise hemodynamics, and the effects on PPCs are uncertain. We hypothesized that intraoperative mechanical ventilation using high PEEP with periodic recruitment maneuvers, as compared with low PEEP without recruitment maneuvers, prevents PPCs in obese patients. Methods/design The PRotective Ventilation with Higher versus Lower PEEP during General Anesthesia for Surgery in OBESE Patients (PROBESE) study is a multice…

MaleLung DiseasesTime Factors[SDV]Life Sciences [q-bio]Respiratory Medicine and Allergymedicine.medical_treatmentRESPIRATORY-DISTRESS-SYNDROMEMedicine (miscellaneous)HemodynamicsMechanical ventilation; Obesity; Positive end-expiratory pressure; Postoperative pulmonary complication; Recruitment maneuver; Medicine (miscellaneous); Pharmacology (medical)LAPAROSCOPIC BARIATRIC SURGERYLung DiseaseBody Mass Indexlaw.inventionPositive-Pressure RespirationStudy Protocol0302 clinical medicineMechanical ventilationClinical ProtocolsRandomized controlled trialRisk Factors030202 anesthesiologylawMedicine and Health SciencesClinical endpointAnesthesiaPharmacology (medical)Respiratory function030212 general & internal medicineLungLungmedicin och allergi2. Zero hungerlcsh:R5-920ddc:617Positive end-expiratory pressurerespiratory systemOperative3. Good healthTreatment OutcomeRecruitment maneuverTIDAL VOLUMESResearch DesignMechanical ventilation Positive end-expiratory pressure Recruitment maneuver Obesity Postoperative pulmonary complicationSurgical Procedures OperativeAnesthesiaBreathingFemaleErratumlcsh:Medicine (General)ALVEOLAR RECRUITMENT MANEUVERHumancirculatory and respiratory physiologymedicine.medical_specialtyTime FactorMechanical ventilation ; Obesity ; Positive end-expiratory pressure ; Postoperative pulmonary complication ; Recruitment maneuverAnesthesia GeneralLung injuryMechanical ventilation; Obesity; Positive end-expiratory pressure; Postoperative pulmonary complication; Recruitment maneuver; Body Mass Index; Clinical Protocols; Female; Humans; Intraoperative Care; Lung; Lung Diseases; Male; Obesity; Positive-Pressure Respiration; Protective Factors; Research Design; Risk Factors; Time Factors; Treatment Outcome; Anesthesia General; Surgical Procedures Operative; Medicine (miscellaneous); Pharmacology (medical)NOGENERAL-ANESTHESIADRIVING PRESSURE03 medical and health sciencesmedicineHumansddc:610ObesityClinical ProtocolGeneralProtective FactorPositive end-expiratory pressurePOSTOPERATIVE PULMONARY COMPLICATIONSMechanical ventilationSurgical ProceduresIntraoperative CareINTERNATIONAL CONSENSUSbusiness.industryRisk FactorProtective FactorsSurgeryMechanical ventilation; Obesity; Positive end-expiratory pressure; Postoperative pulmonary complication; Recruitment maneuverrespiratory tract diseasesbusinessPostoperative pulmonary complicationLUNG INJURY
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MUC16 Is Overexpressed in Idiopathic Pulmonary Fibrosis and Induces Fibrotic Responses Mediated by Transforming Growth Factor-β1 Canonical Pathway

2021

Several transmembrane mucins have demonstrated that they contribute intracellularly to induce fibrotic processes. The extracellular domain of MUC16 is considered as a biomarker for disease progression and death in IPF patients. However, there is no evidence regarding the signalling capabilities of MUC16 that contribute to IPF development. Here, we demonstrate that MUC16 was overexpressed in the lung tissue of IPF patients (n = 20) compared with healthy subjects (n = 17) and localised in fibroblasts and hyperplastic alveolar type II cells. Repression of MUC16 expression by siRNA-MUC16 transfection inhibited the TGF-β1-induced fibrotic processes such as mesenchymal/ myofibroblast transformati…

MaleMUC16Gene ExpressionIdiopathic pulmonary fibrosis0302 clinical medicineBiology (General)PhosphorylationMyofibroblastsLungSpectroscopytransforming growth factor betabiologyChemistryGeneral MedicineTransfectionMiddle Agedrespiratory systemidiopathic pulmonary fibrosisImmunohistochemistryRespiratory Function TestsComputer Science ApplicationsChemistrymedicine.anatomical_structure030220 oncology & carcinogenesisFemaleDisease SusceptibilityMyofibroblastSignal TransductionQH301-705.5Models BiologicalArticleCatalysisCell LineTransforming Growth Factor beta1Inorganic Chemistry03 medical and health sciencesmedicineHumansPhysical and Theoretical ChemistryFibroblastQD1-999Molecular BiologyAgedCell ProliferationA549 cellOrganic ChemistryMesenchymal stem cellMembrane ProteinsTransforming growth factor betaFibroblastsmedicine.diseaserespiratory tract diseases030228 respiratory systemCA-125 AntigenCase-Control StudiesCancer researchbiology.proteinIdiopathic Pulmonary Fibrosis ; Muc16 ; Transforming Growth Factor BetaBiomarkersTransforming growth factorInternational Journal of Molecular Sciences
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Acute cardio-respiratory effects in rats of PS4α, an antineoplastic peptidoglycan from Mycobacterium vaccae

2001

Abstract PS4α is a high molecular weight peptidoglycan extracted from Mycobacterium vaccae, which has demonstrated considerable antineoplastic activity in-vivo without apparent toxicity. Available for testing in only small quantities, a sensitive in-vivo method for measuring pulse and breathing rates in cannulated rats was applied to this compound at doses of 5, 50 and 500 μg kg−1. Various parameters (mean arterial pressure, maximum transpulmonary pressure, compliance, heart rate, minute volume, respiratory rate and tidal volume) were followed for up to 1 h and demonstrated no significant deviation in the baseline values obtained before injection. This compound at doses up to 500 μg kg−1 ha…

MaleMean arterial pressureRespiratory ratePharmaceutical ScienceAntineoplastic AgentsBlood PressurePeptidoglycanPharmacologyBiologyCardiovascular SystemMycobacteriumRats Sprague-DawleyHeart RateAnimalsTidal volumePharmacologyDose-Response Relationship Drugbiology.organism_classificationAcute toxicityRatsRespiratory Function TestsToxicityImmunologyProteoglycansMycobacterium vaccaeRespiratory minute volumeTranspulmonary pressureJournal of Pharmacy and Pharmacology
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Prospective Study on Functional Results After Lung-Sparing Radical Pleurectomy in the Management of Malignant Pleural Mesothelioma

2012

Introduction:Malignant pleural mesothelioma (MPM) can reduce lung function by entrapping lung parenchyma via a rind of tumor with or without concurrent effusion. Radical pleurectomy (RP) allows expansion of the trapped lung. The purpose of this study was to investigate changes in pulmonary function and lung perfusion in patients undergoing RP.Methods:In a prospective, nonrandomized study, all patients with histologically proven MPM were evaluated from January to December 2010 for trimodality therapy including RP as surgical procedure. Pulmonary-function tests and perfusion scans were obtained before and 2 months after RP. Primary end points were pulmonary function (forced vital capacity [FV…

MaleMesotheliomaPulmonary and Respiratory MedicineVital capacitymedicine.medical_specialtyPulmonary functionPleural Neoplasmsmedicine.medical_treatmentVital CapacityUrologyPulmonary function testingFEV1/FVC ratiomedicineHumansProspective StudiesMesotheliomaDecorticationProspective cohort studyPleurectomyAgedLungbusiness.industryrespiratory systemDecorticationPrognosismedicine.diseaseRespiratory Function Testsrespiratory tract diseasesSurgeryPerfusionmedicine.anatomical_structureOncologyEffusionFemalebusinessJournal of Thoracic Oncology
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Hsp10 nuclear localization and changes in lung cells response to cigarette smoke suggest novel roles for this chaperonin

2014

Heat-shock protein (Hsp)10 is the co-chaperone for Hsp60 inside mitochondria, but it also resides outside the organelle. Variations in its levels and intracellular distribution have been documented in pathological conditions, e.g. cancer and chronic obstructive pulmonary disease (COPD). Here, we show that Hsp10 in COPD undergoes changes at the molecular and subcellular levels in bronchial cells from human specimens and derived cell lines, intact or subjected to stress induced by cigarette smoke extract (CSE). Noteworthy findings are: (i) Hsp10 occurred in nuclei of epithelial and lamina propria cells of bronchial mucosa from non-smokers and smokers; (ii) human bronchial epithelial (16HBE) a…

MaleMitochondrionChaperoninPulmonary Disease Chronic ObstructiveCytosolSmokeSettore BIO/10 - Biochimicabronchial epithelial cellChaperonin 10nuclear localizationlcsh:QH301-705.5LungCOPD; Hsp10; bronchial epithelial cells; lung fibroblasts; nuclear localizationbronchial epithelial cellsGeneral NeuroscienceSmokingTobacco ProductsMiddle Aged33ImmunohistochemistryNucleosomesRespiratory Function TestsCell biologymedicine.anatomical_structureFemaleHSP60IntracellularResearch Article1001Hsp10ImmunologyBronchiBiologyGeneral Biochemistry Genetics and Molecular BiologyMitochondrial ProteinsOrganellemedicineHumansCOPDComputer SimulationIsoelectric PointAgedCell NucleusSettore BIO/16 - Anatomia UmanaResearchlung fibroblastsEpithelial CellsChaperonin 60DNAFibroblastsrespiratory tract diseasesMolecular WeightCell nucleusCytosollcsh:Biology (General)Immunologylung fibroblastNuclear localization sequenceOpen Biology
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A cohort study found good respiratory, sensory and motor functions decreased mortality risk in older people

2003

Abstract Background and Objective The main aims of this study were to evaluate the separate and joint effects of respiratory, sensory, and psychomotor function, muscle strength, and mobility in predicting mortality in older men and women, and to find a way to control multicollinearity in a multivariate Cox regression model. Methods Mortality was followed for 10 years (1990–2000) in an entire cohort of 75-year-old residents of the city of Jyvaskyla, Finland (born in 1914; N =388). Cox regression models and principal component estimation were employed to study the association between the covariates and mortality. Results The study indicated that, after adjustment for fatal diseases and cognit…

MaleMultivariate analysisEpidemiologyVital CapacityWalkingMotor ActivityVibrationSex FactorsHumansMedicineMortalityRisk factorMuscle SkeletalAgedPsychomotor functionProportional hazards modelbusiness.industryHazard ratioRespiratory Function TestsStandardized mortality ratioSensory ThresholdsCohortFemaleEpidemiologic MethodsbusinessPsychomotor PerformanceCohort studyDemographyJournal of Clinical Epidemiology
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Noninvasive assessment of respiratory muscle strength and activity in Myotonic dystrophy

2017

Objective To evaluate sensitivity/specificity of the maximum relaxation rate (MRR) of inspiratory muscles, amplitude of electromyographic activity of the sternocleidomastoid (SCM), scalene (SCA), parasternal (2ndIS) and rectus abdominis (RA) muscles; lung function and respiratory muscle strength in subjects with Myotonic dystrophy type 1 (DM1) compared with healthy subjects. Design and methods Quasi-experimental observational study with control group. MRR of inspiratory muscles, lung function and amplitude of the electromyographic activity of SCM, SCA, 2ndIS and RA muscles during maximum inspiratory pressure (PImax), maximum expiratory pressure (PEmax) and sniff nasal inspiratory pressure (…

MaleMuscle PhysiologyTime FactorsMuscle FunctionsPhysiologyMuscle RelaxationRespiratory Systemlcsh:MedicineElectromyographyPulmonary function testing0302 clinical medicineThoracic DiaphragmMedicine and Health SciencesMyotonic DystrophyMedicineRespiratory systemlcsh:ScienceMusculoskeletal SystemAbdominal MusclesMultidisciplinaryAnthropometrymedicine.diagnostic_testMusclesMuscle AnalysisRespiratory MusclesRespiratory Function TestsBioassays and Physiological AnalysisMuscle relaxationInhalationGenetic DiseasesExhalationParasternal lineCardiologyFemaleAnatomyMuscle ElectrophysiologyResearch ArticleAdult; Anthropometry; Electromyography; Exhalation; Female; Humans; Inhalation; Male; Muscle Relaxation; Muscle Strength; Myotonic Dystrophy; Pressure; ROC Curve; Respiratory Function Tests; Respiratory Muscles; Sample Size; Time FactorsAdultmedicine.medical_specialtyRespiratory physiologyResearch and Analysis Methods03 medical and health sciencesInternal medicineRespiratory musclesPressureRespiratory muscleHumansRespiratory PhysiologyMuscle StrengthClinical GeneticsElectromyographic activityElectromyographybusiness.industryElectrophysiological Techniqueslcsh:RBiology and Life SciencesExhalationSkeletal MusclesROC Curve030228 respiratory systemSample Sizelcsh:Qbusiness030217 neurology & neurosurgeryPLOS ONE
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