Search results for "response"
showing 10 items of 4136 documents
Exploring the anticancer potential of pyrazolo[1,2-a]benzo[1,2,3,4] tetrazin-3-one derivatives: The effect on apoptosis induction, cell cycle and pro…
2013
In order to investigate their anticancer potential, four new pyrazolo[1,2-a]benzo[1,2,3,4]-tetrazinone derivatives, designed through the chemometric protocol VLAK, and three of the most active compounds of the previous series have been evaluated on some cellular events including proliferation, apoptosis induction, and cell cycle. The NCI one dose (10 mu M) screening revealed that the 8,9-di-methyl derivative showed activity against Leukemia (CCRF-CEM) and Colon cancer cell line (COLO 205), reaching 81% and 45% of growth inhibition (GI), respectively. Replacement of the two methyl groups with two chlorine atoms maintained the activity toward Leukemia cell (CCRF-CEM, GI 77%) and selectively e…
Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endopl…
2014
The macrolide archazolid inhibits vacuolar-type H(+)-ATPase (V-ATPase), a proton-translocating enzyme involved in protein transport and pH regulation of cell organelles, and potently suppresses cancer cell growth at low nanomolar concentrations. In view of the growing link between inflammation and cancer, we investigated whether inhibition of V-ATPase by archazolid may affect primary human monocytes that can promote cancer by sustaining inflammation through the release of tumor-promoting cytokines. Human primary monocytes express V-ATPase, and archazolid (10-100nM) increases the vesicular pH in these cells. Archazolid (10nM) markedly reduced the release of pro-inflammatory (TNF-α, interleuk…
Interaction of valproic acid and some analogues with microsomal epoxide hydrolase.
1992
Abstract Valproic acid (VPA) and its analogues valpromide (VPM), valproyl-Coenzyme A (VP-CoA) and valproyl-ethylester (VPE) were examined as potential inhibitors of microsomal epoxide hydrolase (mEHb) using styrene-7,8-oxide (STO) and benzo(a)pyrene-4,5-oxide (BPO) as enzyme substrates. The effect of each potential inhibitor was examined using mEHb from rat liver, human livers (from a child, woman and man) and from human placenta. Of the compounds tested, only VPM (2 mM) expressed significant inhibition of mEHb activity with a maximum inhibition of 49%, 48%, 35% and 33% for liver microsomes from the child, woman, man and rat, respectively, using STO (2 mM) as substrate. Human placenta mEHb …
A Management Model of ICT Adoption in Latvia
2012
AbstractThis paper describes and analyzes the validity of a managerial model for ICT adoption. The proposed model of ICT adoption decision has two components: an objective component (largely from an economic understanding) and a managerial component (from firm level factors). The factors in both components were considered at firm level. The analysis and confirmation come from a survey of 500 businesses in Latvia in 2008. Confirmation of the theoretical model was accomplished using Ordered Logistical Regression analysis. Analyses results revealed that the dimensions of perceived benefits (top line growth and efficiency gains), technology absorption capacity (employees openness to change, com…
The origins of the aesthetic enjoyment of music - A review of the literature
2009
Listeners attribute a positive or negative value to music. This aesthetic experience is known to be observable over the individuals’ entire life span, from early childhood to old age, and in every culture. It is then often concluded that such an aesthetic experience constitutes part of the human nature, having an important biological foundation. This assumption leads to the question of how aesthetic experience of music originated in the biological evolution. In this paper, we will explore this question in the light of evolutionary psychology, cognitive science, and systems neuroscience. After reviewing the existing proposals, we conclude that the explanation of the origin of aesthetic expe…
Design of Scales to Assess the subjective social value of education for students in primary and secondary school.
2017
Abstract The devaluation of education, related with multiple socio-economic and psycho-school factors may be influencing decisively on academic results. A target level is observed that the socio-economic and cultural level of families can decide the student performance, however, this international trend shows inconsistent results. In addition, in different studies, we can observe that students from disadvantaged backgrounds statistics exceed expectations in performance, surpassing the expected results depending on their socioeconomic and cultural level; and students should achieve optimal results for their family situation do not get the expected performance. An interpretative hypothesis ma…
Respuesta cardiovascular al estrés en pacientes con epilepsia farmacorresistente: datos preliminares
2021
El estrés es un factor de riesgo para las enfermedades cardiovasculares en la población general. La epilepsia se ha considerado un modelo adecuado de estrés crónico, con mayor incidencia de mortalidad cardiovascular que la población general. Este estudio proporciona datos preliminares sobre la respuesta cardiovascular ante un estresor cognitivo y una evaluación neuropsicológica en pacientes con epilepsia, explorando las relaciones entre la respuesta cardiovascular y el rendimiento cognitivo dependiendo del hemisferio responsable de la epilepsia. Treinta y cinco pacientes con epilepsia farmacorresistente, 17 con el área epileptógena(AE) en el hemisferio izquierdo (LH) y 18 con AE en el hemis…
Integrated thermodynamic and electrical modelling of a variable-speed reversible heat pump: analysis of the cooling mode operation
2022
Variable-speed reversible heat pumps are increasingly adopted for space heating and cooling in residential and tertiary sectors. It is recognized that these systems will play a key role in medium- and small-scale 4th generation district heating and cooling networks. Indeed, with the high penetration of intermittent renewable energy sources, such technology could help reduce issues related to the surplus of electricity from renewable energy sources by converting it into heat or cold. To reliably assess the benefits achievable in these emerging applications, it is necessary to develop models which can simulate not only the steady-state operation but also the dynamic response of the system wit…
Comparing Traditional and IRT Scoring of Forced-Choice Tests.
2018
This article explores how traditional scores obtained from different forced-choice (FC) formats relate to their true scores and item response theory (IRT) estimates. Three FC formats are considered from a block of items, and respondents are asked to (a) pick the item that describes them most (PICK), (b) choose the two items that describe them the most and the least (MOLE), or (c) rank all the items in the order of their descriptiveness of the respondents (RANK). The multi-unidimensional pairwise-preference (MUPP) model, which is extended to more than two items per block and different FC formats, is applied to obtain the responses to each item block. Traditional and IRT (i.e., expected a po…
In Vivo Modulation of Angiogenesis and Immune Response on a Collagen Matrix via Extracorporeal Shockwaves
2020
The effective management of tissue integration and immunological responses to transplants decisively co-determines the success of soft and hard tissue reconstruction. The aim of this in vivo study was to evaluate the eligibility of extracorporeal shock wave therapy (ESWT) with respect to its ability to modulate angiogenesis and immune response to a collagen matrix (CM) for tissue engineering in the chorioallantoic membrane (CAM) assay, which is performed with fertilized chicken eggs. CM were placed on the CAM on embryonic development day (EDD) 7