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showing 10 items of 2426 documents
The Biopharmaceutics Classification System: Subclasses for in vivo predictive dissolution (IPD) methodology and IVIVC
2013
The Biopharmaceutics Classification System (BCS) has found widespread utility in drug discovery, product development and drug product regulatory sciences. The classification scheme captures the two most significant factors influencing oral drug absorption; solubility and intestinal permeability and it has proven to be a very useful and a widely accepted starting point for drug product development and drug product regulation. The mechanistic base of the BCS approach has, no doubt, contributed to its wide spread acceptance and utility. Nevertheless, underneath the simplicity of BCS are many detailed complexities, both in vitro and in vivo which must be evaluated and investigated for any given…
Protective and Risk Factors for Adolescent Substance Use in Spain: Self-Esteem and Other Indicators of Personal Well-Being and Ill-Being
2020
Although self-esteem has traditionally been considered as an important correlate of psychosocial adjustment, some empirical studies have found a positive relationship between some domains of self-esteem and drug use among adolescents. The present study analyzes self-esteem and other adjustment personal indicators as protective or risk factors for substance use. Participants were 644 Spanish adolescents aged 12&ndash
Erste Erfahrungen mit Amisulprid, einem in Deutschland neuen, atypischen Neuroleptikum in der Behandlung von Jugendlichen mit psychischen Erkrankungen
2001
Zusammenfassung: Fragestellung: Neben den klassischen Neuroleptika finden bei Jugendlichen zunehmend atypische Neuroleptika zur Behandlung schizophrener und schizoaffektiver Psychosen Verwendung. Seit Beginn des Jahres 1999 ist in Deutschland in der Behandlung akuter schizophrener Psychosen ein neues, offensichtlich wirkungsvolles Neuroleptikum aus der Gruppe der Benzamide verfügbar: Amisulprid. Erste Erfahrungen mit der Anwendung von Amisulprid werden berichtet. Methode: Zehn gut dokumentierte Behandlungsverläufe bei Jugendlichen unter Behandlung mit Amisulprid werden hinsichtlich Effektivität, unerwünschter Wirkungen und Dosierung berichtet. Ergebnisse: Erste Erfahrungen im Einsatz von Am…
Development of a Multiparametric Cell-based Protocol to Screen and Classify the Hepatotoxicity Potential of Drugs
2012
Hepatotoxicity is a major reason for drug nonapprovals and withdrawals. The multiparametric analysis of xenobiotic toxicity at the single cells level using flow cytometry and cellular imaging-based approaches, such as high-content screening (HCS) technology, could play a key role in the detection of toxicity and the classification of compounds based on patterns of cellular injury. This study aimed to develop and validate a practical, reproducible, in vitro multiparametric cell-based protocol to assess those drugs that are potentially hepatotoxic to humans and to suggest their mechanisms of action. The assay was applied to HepG2 human cell line cultured in 96-well plates and exposed to 78 di…
Evaluation of Internet Social Networks using Net scoring Tool: A Case Study in Adverse Drug Reaction Mining
2015
Suspected adverse drug reactions (ADR) reported by patients through social media can be a complementary tool to already existing ADRs signal detection processes. However, several studies have shown that the quality of medical information published online varies drastically whatever the health topic addressed. The aim of this study is to use an existing rating tool on a set of social network web sites in order to assess the capabilities of these tools to guide experts for selecting the most adapted social network web site to mine ADRs.First, we reviewed and rated 132 Internet forums and social networks according to three major criteria: the number of visits, the notoriety of the forum and th…
Condizioni per l’incidenza della ricerca didattica nel miglioramento della scuola
2018
Il dibattito in corso sull’ Evidence Based Education (EBE) dimostra come la questione della cumulabilità delle conoscenze didattiche sia particolarmente sentita da coloro che si occupano di ricerca empirica in campo scolastico. E’ avvertita l’esigenza di fare il punto su quanto nella comunità scientifica si sa, con un’accettabile certezza, su un determinato tema, senza dover ogni volta ripartire da zero. Il problema è formulabile in questi termini: fino a che punto e a quali condizioni è possibile cumulare i risultati delle ricerche empiriche in campo didattico, per ricavare da essi utili indicazioni per le azioni degli insegnanti, che auspicabilmente dovrebbero essere coinvolti dai ricerca…
A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts
2020
Polymerase chain reaction (PCR) detection has become the gold standard for diagnosis and typing of enterovirus (EV) and human parechovirus (HPeV) infections. Its effectiveness depends critically on using the appropriate sample types and high assay sensitivity as viral loads in cerebrospinal fluid samples from meningitis and sepsis clinical presentation can be extremely low. This study evaluated the sensitivity and specificity of currently used commercial and in‐house diagnostic and typing assays. Accurately quantified RNA transcript controls were distributed to 27 diagnostic and 12 reference laboratories in 17 European countries for blinded testing. Transcripts represented the four human EV…
Determinants of COVID-19 Vaccine Rollouts and Their Effects on Health Outcomes
2022
Background Vaccination against the coronavirus disease (SARS-CoV-2) is understood to be the key way out of the COVID-19 pandemic. Limited evidence exists on the determinants of vaccine rollouts and their health effects at the country level. Objective Examine the determinants of COVID-19 vaccine rollouts and their effects on health outcomes. Methods Ordinary least squares regressions with standard errors clustered at the country level for Cross-section and Panel daily data of vaccinations and various health outcomes (new COVID-19 cases, fatalities, intensive care unit (ICU) admissions) for an unbalanced sample of about 200 countries during the period 16 December 2020 to 20 June 2021. Results…
Student's achievement in french at junior high school
2012
Communication affichée - Résumé reproduit in International Journal of Psychology, 47, supplement 1, p. 20.; This research aims at studying, by means of a theoretical model, the role of certain personal features (gender, age, socioeconomic background, academic record) and some dynamical mechanisms of personality in predicting the students' achievement in French at junior high school. The dynamical mechanisms, relating to the affective entry characteristics (Bloom, 1979), were represented by five attitudes towards school: Negative feelings, Lack of scholastic interest, Aspirations for future studies, "Scholastic anxiety, worry and stress" and "Nice school, distraction place" (Bennacer, 2003).…
El trastorn de dèficit d'atenció amb hiperactivitat (TDAH) en població infantil i juvenil
2012
Fruit de la dedicació professional de les autores i enfront d'un problema no sols no resolt, sinó que es considera que està insuficientment abordat, el trastorn de dèficit d'atenció amb hiperactivitat (TDAH) en població infantil i juvenil, es planteja primerament una revisió de la bibliografia, seguida d'un recull de dades sobre la situació actual (amb abundància d'informació procedent dels Estats Units) i d'algunes consideracions i propostes per a posar en marxa les intervencions al nostre àmbit de referència, com ara l'educació que han de rebre, les concepcions morals, els hàbits, etc. Perquè avui dia els infants estan exposats a nombroses influències que han desencadenat que es disparen …