Search results for "retinal pigment epithelium"

showing 2 items of 62 documents

Cholesterol and ocular pathologies: focus on the role of cholesterol-24S-hydroxylase in cholesterol homeostasis

2015

The retina is responsible for coding the light stimulus into a nervous signal that is transferred to the brain via the optic nerve. The retina is formed by the association of the neurosensory retina and the retinal pigment epithelium that is supported by Bruch’s membrane. Both the physical and metabolic associations between these partners are crucial for the functioning of the retina, by means of nutrient intake and removal of the cell and metabolic debris from the retina. Dysequilibrium are involved in the aging processes and pathologies such as age-related macular degeneration, the leading cause of visual loss after the age of 50 years inWestern countries. The retina is composed of severa…

medicine.medical_specialtyretinaOrganes des sensgenetic structuresrétineCellSensory OrgansMédecine humaine et pathologielcsh:TP670-699BiologyBiochemistrydégénérescence maculaire liée à l'âgechemistry.chemical_compoundlipid[ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathologyInternal medicinemedicine[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organsage-related macular degenerationlipideRetinaRetinal pigment epitheliumCholesterolagingcholesterolcholestérolMetabolismMacular degenerationmedicine.diseaseSteroleye diseasesmedicine.anatomical_structureEndocrinologyglaucomachemistry[ SDV.MHEP.OS ] Life Sciences [q-bio]/Human health and pathology/Sensory OrgansglaucomeOptic nerveHuman health and pathologysense organslcsh:Oils fats and waxesretina;lipid;cholesterol;glaucoma;age-related macular degeneration;aging;rétine;lipide;cholestérol;glaucome;dégénérescence maculaire liée à l'âgeAgronomy and Crop Science[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyFood Science
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Analysis of a soluble lipid-protein complex carrying endogenous 11-cis retinaldehyde from bovine retinal pigment epithelium.

1989

A soluble lipid-protein complex in bovine retinal pigment epithelium is shown to carry endogenous 11-cis retinaldehyde, in the extent of 15% of the total 11-cis retinaldehyde found in this tissue. The complex, analyzed with respect to its chemical composition, exhibits a lipid composition close resembling the lipid composition of the rod outer segment membrane; the SDS-PAGE evidences the presence of a number of protein bands, two of which of 34 and 27 kDa appear glycoproteins. Finally, the lipid-protein complex exhibits a discrete level of a Cathepsin D-like protease activity. From the above, the possibility is discussed that the soluble lipid-protein complex could represent some phagolysos…

medicine.medical_treatmentPhagocytosisLipoproteinsClinical BiochemistryEndogenyBiologyPigmentRetinoidsCytosolmedicineAnimalsPigment Epithelium of EyeMolecular BiologyPhospholipidsTriglycerideschemistry.chemical_classificationCathepsinProteaseRetinal pigment epitheliumCell BiologyGeneral MedicineMolecular Weightmedicine.anatomical_structureCholesterolchemistryBiochemistryvisual_artRetinaldehydevisual_art.visual_art_mediumChromatography GelRetinaldehydeCattleElectrophoresis Polyacrylamide GelGlycoproteinCarrier ProteinsMolecular and cellular biochemistry
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