Search results for "reversibility"
showing 10 items of 17 documents
Reversibility of Central Nervous System Adverse Events in Course of Art
2022
The purpose of this study is to evaluate the frequency of central nervous system adverse events (CNS-AE) on dolutegravir (DTG) and non-DTG containing ART, and their reversibility, in the observational prospective SCOLTA cohort. Factors associated with CNS-AE were estimated using a Cox proportional-hazards model. 4939 people living with HIV (PLWH) were enrolled in DTG (n = 1179) and non-DTG (n = 3760) cohorts. Sixty-six SNC-AE leading to ART discontinuation were reported, 39/1179 (3.3%) in DTG and 27/3760 (0.7%) in non-DTG cohort. PLWH naïve to ART, with higher CD4 + T count and with psychiatric disorders were more likely to develop a CNS-AE. The risk was lower in non-DTG than DTG-cohort (aH…
On singularities of discontinuous vector fields
2003
Abstract The subject of this paper concerns the classification of typical singularities of a class of discontinuous vector fields in 4D. The focus is on certain discontinuous systems having some symmetric properties.
A novel strategy for solving the stochastic point location problem using a hierarchical searching scheme
2014
Stochastic point location (SPL) deals with the problem of a learning mechanism (LM) determining the optimal point on the line when the only input it receives are stochastic signals about the direction in which it should move. One can differentiate the SPL from the traditional class of optimization problems by the fact that the former considers the case where the directional information, for example, as inferred from an Oracle (which possibly computes the derivatives), suffices to achieve the optimization-without actually explicitly computing any derivatives. The SPL can be described in terms of a LM (algorithm) attempting to locate a point on a line. The LM interacts with a random environme…
Exergy analysis of electrodialysis for water desalination: Influence of irreversibility sources
2022
The increasing freshwater demand is pushing the development and adoption of desalination technologies. In this framework, electrodialysis has a consolidated role in brackish water desalination, but to make it competitive with other technologies for the desalination of more concentrated solutions (e.g., seawater), the specific energy consumption should be reduced. Exergy analysis provides a useful tool for determining the contribution of each thermodynamic inefficiencies on the process efficiency and the specific energy consumption. In this regard, this paper presents an exergy analysis of the electrodialysis process. A 1-D model is used for evaluating the performance of industrial-scale sys…
Tests for time reversibility: a complementarity analysis
2003
Abstract Since time reversibility (TR) is a necessary condition for an independent and identically distributed (iid) sequence, several tests for TR have been suggested to be applied as tests for model misspecification. In this paper, we analyze possible complementarities among two well known TR tests (Ramsey and Rothman's test, and Chen et al.'s test) in two situations: (1) the fitted model is a linear ARMA model when the true data generating process is a nonlinear-in-mean model (either threshold autoregressive or bilinear), and (2) the fitted model is a symmetric GARCH model but the true process belongs to the asymmetric GARCH family (either EGARCH or GJR). The results suggest that there a…
Calorie Restriction in Adulthood Reduces Hepatic Disorders Induced by Transient Postnatal Overfeeding in Mice
2019
International audience; Impaired early nutrition influences the risk of developing metabolic disorders in later life. We observed that transient postnatal overfeeding (OF) in mice induces long-term hepatic alterations, characterized by microsteatosis, fibrosis associated with oxidative stress (OS), and stress-induced premature senescence (SIPS). In this study, we investigated whether such changes can be reversed by moderate calorie restriction (CR). C57BL/6 male mice pups were maintained during lactation in litters adjusted to nine pups in the normal feeding (NF) group and three pups in the transient postnatal OF group. At six months of age, adult mice from the NF and OF groups were randoml…
Irreversible gelation of thermally unfolded proteins:structural and mechanical properties of lysozyme aggregates
2010
The formation of protein aggregates is important in many fields of life science and technology. The morphological and mechanical properties of protein solutions depend upon the molecular conformation and thermodynamic and environmental conditions. Non-native or unfolded proteins may be kinetically trapped into irreversible aggregates and undergo precipitation or gelation. Here, we study the thermal aggregation of lysozyme in neutral solutions. We characterise the irreversible unfolding of lysozyme by differential scanning calorimetry. The structural properties of aggregates and their mechanisms of formation with the eventual gelation are studied at high temperature by spectroscopic, rheolog…
ERGODICITY IN RANDOMLY COLLIDING QUBITS
2009
The dynamics of a single qubit randomly colliding with an environment consisting of just two qubits is discussed. It is shown that the system reaches an equilibrium state which coincides with a pure random state of three qubits. Furthermore the time average and the ensemble averages of the quantities used to characterize the approach to equilibrium (purity and tangles) coincide, a signature of ergodic behavior.
Persistence of both reversible airway obstruction and higher blood eosinophils may predict lung function decline in severe asthma.
2021
Objective: This study analysed whether the persistence of both reversible airway obstruction (RAO) and elevated BE counts was associated to reduced asthma control and accelerated lung function decline in treated severe asthmatics. Methods: About 202 severe asthmatics were studied after 12–120 months of step-5 treatment associated to anti-IgE therapy. Following treatments, reversibility tests, after inhaling 400 mcg of Salbutamol, were performed. FEV1 > 12% or ≤12% changes differentiated RAO+ from RAO− subjects. Blood eosinophil (BE) counts after treatment were considered. Results: Pre-/post-treatment bronchodilator FEV1% and ACT were lower (61% [50–71], 74.4% [62.5–83.7] and 20[18–22]), …
Integrability via Reversibility
2017
Abstract A class of left-invariant second order reversible systems with functional parameter is introduced which exhibits the phenomenon of robust integrability: an open and dense subset of the phase space is filled with invariant tori carrying quasi-periodic motions, and this behavior persists under perturbations within the class. Real-analytic volume preserving systems are found in this class which have positive Lyapunov exponents on an open subset, and the complement filled with invariant tori.