Search results for "rex"
showing 10 items of 701 documents
Aversive tension of adolescents with anorexia nervosa in daily course: a case-controlled and smartphone-based ambulatory monitoring trial.
2014
Introduction Monitoring and reduction of aversive tension is a core issue in dialectical behaviour therapy of patients. It has been shown that aversive tension is increased in adult borderline personality disorder and is linked to low emotion labelling ability. However, until now there is no documented evidence that patients with anorexia nervosa suffer from aversive tension as well. Furthermore the usability of a smartphone application for ambulatory monitoring purposes has not been sufficiently explored. Methods and analysis We compare the mean and maximum self-reported aversive tension in 20 female adolescents (12–19 years) with anorexia nervosa in outpatient treatment with 20 healthy co…
Emotion regulation in adolescents with anorexia and bulimia nervosa: Differential use of adaptive and maladaptive strategies compared to healthy adol…
2021
Objective: Adolescents with anorexia (AN) and bulimia nervosa (BN) often struggle with emotion regulation (ER). These difficulties have predominantly been assessed across emotions, without considering adaptive and maladaptive ER separately.We compared adolescents with AN or BN to healthy adolescents (HCs) regarding the adaptive and maladaptive ER of three emotions. Methods: A treatment-seeking sample of 197 adolescents (atypical/full-threshold AN: N = 118, atypical/full-threshold BN: N = 32; HC: N = 47) reported emotion-specific ER with the FEEL-KJ questionnaire. Mixed models were calculated for adaptive and maladaptive ER to assess differences between emotions (anxiety, anger, sadness) and…
Altered Mitochondrial Function and Oxidative Stress in Leukocytes of Anorexia Nervosa Patients
2014
ContextAnorexia nervosa is a common illness among adolescents and is characterised by oxidative stress.ObjectiveThe effects of anorexia on mitochondrial function and redox state in leukocytes from anorexic subjects were evaluated.Design and settingA multi-centre, cross-sectional case-control study was performed.PatientsOur study population consisted of 20 anorexic patients and 20 age-matched controls, all of which were Caucasian women.Main outcome measuresAnthropometric and metabolic parameters were evaluated in the study population. To assess whether anorexia nervosa affects mitochondrial function and redox state in leukocytes of anorexic patients, we measured mitochondrial oxygen consumpt…
Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders: Data From a New Biobank and Meta-Analysis of Previously Published St…
2017
Objectives: We investigated whether catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with eating disorders (EDs). Methods: We conducted a systematic literature search of studies published until 15 January 2017 and added data from the Italian ‘Biobanca Veneta per i Disturbi Alimentari’ biobank, performing a meta-analysis comparing COMT Val158Met genotype and allele frequencies in EDs and anorexia nervosa (AN) or bulimia nervosa (BN) patients versus controls. Results: Ten studies plus Biobanca Veneta per i Disturbi Alimentari (ED: n = 920, controls: n = 261 controls) with 3541 ED patients (AN = 2388; BN = 233) and 3684 controls were included. There were no significant …
Molecular bases of anorexia nervosa, bulimia nervosa and binge eating disorder: shedding light on the darkness
2017
International audience; Eating-disorders (EDs) consequences to human health are devastating, involving social, mental, emotional, physical and life-threatening aspects, concluding on impairment and death in cases of extreme anorexia nervosa. It also implies that people suffering an ED need to find psychiatric and psychological help as soon as possible to achieve a fully physical and emotional recovery. Unfortunately, to date, there is a crucial lack of efficient clinical treatment to these disorders. In this review, we present an overview concerning the actual pharmacological and psychological treatments, the knowledge of cells, circuits, neuropeptides, neuromodulators and hormones in the h…
Is the selective information processing of food and body words specific to patients with eating disorders?
1993
The selective processing of food- and body size-related information was investigated using a modified version of the Stroop task. Anorexic and bulimic patients and matched female controls were compared on the basis of categorical (diagnosis), dimensional (restraint and drive for thinness) criteria, or both. The findings suggest that the phenomenon assessed by the Stroop paradigm is not exclusive to patients with a clinical eating disorder, but patients and those control subjects who are restrained eaters with a high drive for thinness share a selective processing of information related to shape and eating. The discussion focuses on the implications of these findings. © 1993 by lohn Wiley & …
La transversalidad de los trastornos del comportamiento alimentario: un reto para los cuidados de salud
2004
Los trastornos de la conducta alimentaria son una causa importante de morbilidad física y psicosocial en jóvenes adolescentes y en mujeres adultas jóvenes y, aunque en distinto grado, afectan a personas tanto de países desarrollados como de países en vías de desarrollo. En este trabajo se expone como ejemplo la situación España y Perú. Se trata de un problema de origen multicausal que es transversal a condiciones socioeconómicas y clase social y en la actualidad, es la teoría del factor sociocultural la que mejor soporta la interpretación de los datos disponibles. En este contexto, el rol y la responsabilidad que compete a Enfermería y a otros profesionales de la salud tiene grandes dimensi…
The New Microtubule-Targeting Agent SIX2G Induces Immunogenic Cell Death in Multiple Myeloma
2022
Microtubule-targeting agents (MTAs) are effective drugs for cancer treatment. A novel diaryl [1,2]oxazole class of compounds binding the colchicine site was synthesized as cis-restricted-combretastatin-A-4-analogue and then chemically modified to have improved solubility and a wider therapeutic index as compared to vinca alkaloids and taxanes. On these bases, a new class of tricyclic compounds, containing the [1,2]oxazole ring and an isoindole moiety, has been synthetized, among which SIX2G emerged as improved MTA. Several findings highlighted the ability of some chemotherapeutics to induce immunogenic cell death (ICD), which is defined by the cell surface translocation of Calreticulin (CAL…
Asymptotic behavior for the heat equation in nonhomogeneous media with critical density
2013
Abstract We study the long-time behavior of solutions to the heat equation in nonhomogeneous media with critical singular density | x | − 2 ∂ t u = Δ u , in R N × ( 0 , ∞ ) in dimensions N ≥ 3 . The asymptotic behavior proves to have some interesting and quite striking properties. We show that there are two completely different asymptotic profiles depending on whether the initial data u 0 vanishes at x = 0 or not. Moreover, in the former the results are true only for radially symmetric solutions, and we provide counterexamples to convergence to symmetric profiles in the general case.
Reducing Mortality of Shrews in Rodent Live Trapping — a Method Increasing Live-Trap Selectivity with Shrew Exits
2013
Shrews have very high metabolic rates and are often unintentionally starved in rodent live-traps during capture-mark-recapture (CMR) studies. Here, we suggest a shrew exit as a modification to rodent traps. To test whether this modification is (1) saving shrews and (2) not jeopardizing results of rodent captures, we compared captures in Ugglan traps with and without shrew exits, studying bank voles (Myodes glareolus) in a spruce forest in central Finland. Numbers of captured bank voles and body size of smallest juvenile bank voles were not affected by the shrew exit, while the number of captured common shrews (Sorex araneus) was reduced from 31 to 0 individuals per 100 trap nights. However,…