Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders: Data From a New Biobank and Meta-Analysis of Previously Published Studies.

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RESEARCH PRODUCT

Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders: Data From a New Biobank and Meta-Analysis of Previously Published Studies.

Enrico Collantoni Marco Solmi Davide Gallicchio Paolo Santonastaso Paolo Meneguzzo Andrè F Carvalho Brendon Stubbs Maurizio Clementi Claudia Pinato Monica Forzan Matteo Cassina Francesca Fontana Ivana Piva Roberta Siani Pierandrea Salvo Elena Tenconi Nicola Veronese Christoph U Correll Angela Favaro

subject

Anorexia Nervosa Genotype Val158Met Catechol O-Methyltransferase Polymorphism Single Nucleotide catechol-O-methyltransferase (COMT)polymorphism Feeding and Eating Disorders Gene Frequency Case-Control Studies mental disorders Journal Article Humans Bulimia Nervosa Val158Met; anorexia nervosa; bulimia nervosa; catechol-O-methyltransferase (COMT); polymorphism Biological Specimen Banks

description

Objectives: We investigated whether catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with eating disorders (EDs). Methods: We conducted a systematic literature search of studies published until 15 January 2017 and added data from the Italian ‘Biobanca Veneta per i Disturbi Alimentari’ biobank, performing a meta-analysis comparing COMT Val158Met genotype and allele frequencies in EDs and anorexia nervosa (AN) or bulimia nervosa (BN) patients versus controls. Results: Ten studies plus Biobanca Veneta per i Disturbi Alimentari (ED: n = 920, controls: n = 261 controls) with 3541 ED patients (AN = 2388; BN = 233) and 3684 controls were included. There were no significant group differences in COMT Val158Met alleles and genotype frequencies between patients and controls, for all EDs pooled together [range of odds ratios (ORs): 0.96–1.04, p-values: 0.46–0.97, I2 = 0%] and when analysing separately patients with AN (ORs: 0.94–1.04, p-values: 0.31–0.61, I2 = 0%) or BN (ORs: 0.80–1.09, p-values: 0.28–0.64, I2 = 0–44%). Conclusions: Meta-analysing data results from 11 studies and 7225 subjects show that COMT Val158Met polymorphism is not associated with EDs. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.

year	journal	country	edition	language
2017-01-01	European eating disorders review : the journal of the Eating Disorders Association

10.1002/erv.2555 https://pubmed.ncbi.nlm.nih.gov/29057600