Search results for "rheumatoid arthriti"

showing 10 items of 211 documents

Rheumatoid arthritis associated with the occurrence, severity and extension of periodontitis : a case-control study

2021

Background Emerging evidence pointed to a potential association between periodontitis (PE) and rheumatoid arthritis (RA), based on shared characteristics and similarities in risk factors, immunogenetics and pathways of tissue destruction. The aim of this study was to evaluate the potential association between RA and PE, as well as the influence of risk variables in this association. Material and Methods The present case-control study comprised 471 individuals (157 cases with RA and 314 controls) that underwent a full-mouth periodontal examination. The association between risk variables and the occurrence of AR and PE were evaluated through univariate and multivariate logistic analysis. Resu…

Periodontitismedicine.medical_specialtybusiness.industryPeriodontal examinationResearchCase-control studyImmunogeneticsmedicine.diseaseDental flossInternal medicineRheumatoid arthritisLogistic analysismedicinePeriodontologybusinessGeneral DentistryUNESCO:CIENCIAS MÉDICAS
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Association between rheumatoid arthritis and periodontitis in an adult population – A cross sectional study

2021

Background This investigation was aimed to analyse the existence of an association between rheumatoid arthritis and periodontitis among Indian subjects. Material and Methods This observational study included a total of 110 individuals between 18-78 years of age, which were divided equally into RA (Rheumatoid Arthritis) and NRA (Non-Rheumatoid Arthritis) groups. General, Oral and a complete Periodontal examination included recording of Gingival Index (GI), Plaque index (PI), Pocket Probing Depth (PPD), Clinical attachment level (CAL) in a questionnaire form. Laboratory and rheumatologcal parameters like C-reactive protein (CRP), Erythrocyte sedimentation rate (ESR) and Disease Activity Score…

Periodontitismedicine.medical_specialtymedicine.diagnostic_testbusiness.industryResearchArthritisOdds ratiomedicine.diseaseChronic periodontitisSevere periodontitisErythrocyte sedimentation rateRheumatoid arthritisInternal medicinemedicineRheumatoid factorPeriodontologybusinessGeneral DentistryUNESCO:CIENCIAS MÉDICASJournal of Clinical and Experimental Dentistry
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Hsp60 and Hsp10 as antitumour molecular agents

2007

The molecular chaperones Hsp60 and Hsp10 are, according to recent reports, involved in cancer development and progression. We, for instance, have found that their expression varies with distinctive patterns in different malignancies: they are overexpressed in colorectal, exocervical and prostate carcinogenesis, and colorectal cancer progression, but they are downregulated during bronchial carcinogenesis. There is also evidence showing that Hsp60 and Hsp10 can be used as therapeutic agents, for example in rheumatoid arthritis. In view of these findings we want now to call attention to the potential of Hsp60 and Hsp10 in cancer therapy.

PharmacologyOncologyCancer Researchmedicine.medical_specialtyanimal structuresbusiness.industryColorectal cancermedicine.medical_treatmentfungiCancerImmunotherapyMouse model of colorectal and intestinal cancermedicine.diseasemedicine.disease_causeOncologyRheumatoid arthritisInternal medicineMolecular MedicineMedicineHSP60Cancer developmentbusinessCarcinogenesisCancer Biology & Therapy
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T cell-independent joint destruction

1998

Rheumatoid Arthritis (RA) is a chronic systemic disorder of unknown etiology. Although, early and late stages of the disease may be driven by different processes, affected joints are characterized by inflammation, synovial hyperplasia, and abnormal immune responses [1]. The abundance of T cells within the rheumatoid synovium as well as the association of certain major histocompatibility complex (MHC) class II molecules with RA [2] implied a central role for T cells in the pathophysiology of the disease. However, recent advances in molecular biology have fostered new concepts for the pathogenesis of RA. Specifically, the investigation of early stages of disease, the development of novel anim…

Property (philosophy)media_common.quotation_subjectT cellInflammationDiseaseBiologyMajor histocompatibility complexExperiential learningExistentialismPathogenesisMode (music)Immune systemPerceptionSynovitismedicineRelation (history of concept)media_commonTime perceptionmedicine.diseasemedicine.anatomical_structureRheumatoid arthritisImmunologySpitebiology.proteinmedicine.symptomPsychologyCognitive psychology
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Physical inactivity in patients with rheumatoid arthritis: data from twenty-one countries in a cross-sectional, international study.

2008

Objective Regular physical activity is associated with decreased morbidity and mortality. Traditionally, patients with rheumatoid arthritis (RA) have been advised to limit physical exercise. We studied the prevalence of physical activity and associations with demographic and disease-related variables in patients with RA from 21 countries. Methods The Questionnaires in Standard Monitoring of Patients with Rheumatoid Arthritis (QUEST-RA) is a cross-sectional study that includes a self-report questionnaire and clinical assessment of nonselected consecutive outpatients with RA who are receiving usual clinical care. Frequency of physical exercise (≥30 minutes with at least some shortness of brea…

QuestionnairesMalemedicine.medical_specialtyInternationalityCross-sectional studyImmunologyArthritisPhysical exerciseMotor Activity*Arthritis Rheumatoid/physiopathologyArthritis RheumatoidRheumatologyInternal medicineImmunopathologySurveys and QuestionnairesmedicineImmunology and AllergyHumansPharmacology (medical)In patient*Motor Activitybusiness.industryMiddle Agedmedicine.diseaseComorbidityObesityCross-Sectional StudiesRheumatoid arthritisPhysical therapyFemalebusiness
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Efficacy and safety of rituximab with and without methotrexate in the treatment of rheumatoid arthritis patients: Results from the GISEA register

2014

Abstract Introduction Rituximab (RTX) is a monoclonal anti-CD20 antibody approved for the treatment of rheumatoid arthritis (RA) in association with methotrexate (MTX). Objectives To evaluate the efficacy and safety of RTX–MTX combination therapy compared with RTX alone in the treatment of RA. Methods We analyzed data from a prospective cohort study, the Italian biologic register GISEA, to investigate the efficacy and safety of rituximab. Moreover, the adverse events (AE) and the causes of discontinuation therapy were analyzed. Results We identified 338 RA patients, 162 treated with RTX and 176 with RTX–MTX. After 52 and 104 weeks of therapy the disease activity score in 28 joints and the H…

RegistrieMaleanti-CD20 rituximab; rheumatoid arthritis; GISEArheumatoid arthritisSettore MED/16 - REUMATOLOGIAAnti-CD20Arthritis RheumatoidAntibodies Monoclonal Murine-DerivedRheumatoidMonoclonalRegistriesProspective cohort studyGISEAAnti-CD20; Methotrexate; Rheumatoid arthritis; Rituximab; Adult; Aged; Antibodies Monoclonal; Antibodies Monoclonal Murine-Derived; Antirheumatic Agents; Arthritis Rheumatoid; Drug Therapy Combination; Female; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome; RegistriesAntirheumatic AgentAntibodies MonoclonalMiddle AgedTreatment OutcomeRituximab rheumatoid arthritisAntirheumatic AgentsRheumatoid arthritisCombinationMonoclonalDrug Therapy CombinationFemaleRituximabRituximabHumanmedicine.drugmusculoskeletal diseasesAdultMurine-Derivedmedicine.medical_specialtyCombination therapyAntibodiesNOAnti-CD20; Methotrexate; Rheumatoid arthritis; RituximabDrug TherapyRheumatologyanti-CD20 rituximabInternal medicinemedicineHumansRheumatoid arthritisAdverse effectRheumatoid arthritiAnti-CD20; Methotrexate; Rheumatoid arthritis; Rituximab; Adult; Aged; Antibodies Monoclonal; Antibodies Monoclonal Murine-Derived; Antirheumatic Agents; Arthritis Rheumatoid; Drug Therapy Combination; Female; Humans; Male; Methotrexate; Middle Aged; Rituximab; Treatment Outcome; Registries; RheumatologyAgedbusiness.industryArthritismedicine.diseaseSurgeryDiscontinuationMethotrexateMethotrexatebusinessJoint Bone Spine
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Metilazione del DNA in artrite reumatoide

2005

Lo stato di metilazione del DNA genomico e del gene PTHrP è stato valutato con tecniche molecolari e citogenetiche in artrite reumatoide (AR), patologia autoimmune caratterizzata anche da alta incidenza di linfomi e da ipercalcemia per overespressione del gene PTHrP. La metilazione del DNA, infatti, ha un ruolo critico nello sviluppo delle malattie neoplastiche; il gene PTHrP avendo tre promotori uno dei quali contiene un’isola CpG è un buon candidato per la deregolazione da alterato pattern di metilazione locale. Le indagini sulla metilazione genomica, condotte su DNA estratto da sangue periferico di pazienti e di donatori e amplificato in reazioni di Methylation-Sensitive Arbitrarily Prim…

Settore BIO/18 - Geneticainstead chromosomes of controls were almost uniformly decorated by brilliant grains. Studies on methylation of PTHrP gene promoter 2 performed on five CpG island internal sites using the Methylation-Sensitive Restriction Endonuclease Multiplex (MSREM)-PCR showed that one of the sites nearest the trascription starting point is heavy methylated in a significantly high number of RA patients. Thus RA seems to be characterized by genomewide hypomethylation associated with local hypermethylation like the most part of tumors. This result raises the possibility that susceptibility to lymphomas is related to abnormal DNA methylation levels and suggests the opportunity to evaluate the DNA methylation status in RA patientin fact the demethylating therapies together with diet and life style can act towards an increase of tumor risk. Future studies using a larger number of subjects could confirm these findings.Rheumatoid Arthritis (RA) is a chronic multisystem inflammatory disease characterized by high recurrence of lymphomas as well as hypercalcemia due to PTHrP overexpression. Because of DNA methylation plays a critical role in development of neoplasias we determined in RA patients the global DNA methylation status and local methylation pattern of the CpG island of one of the three promoters of PTHrP gene utilizing molecular and cytogenetic techniques. Investigations performed on DNA from peripheral blood of patients and donors amplified by Methylation-Sensitive Arbitrarily Primed (MeS-AP)-PCR indicated that RA is strongly associated with global DNA hypomethylation. Similarly chromosomal DNA methylation pattern analysis by indirect immunofluorescence technique with anti 5-methylcitosine antibody showed all peripheral lymphocyte metaphases from RA patients with chromosomes weakly fluorescent without discrete grain
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Hypocomplementemia in children with juvenile idiopatic arthritis treated with tocilizumab: personal records

2017

The relieve of a reduction in complement levels was recently reported in adults with Rheumatoid Arthritis treated with tocilizumab (TCZ). However, there are no data in children with Juvenile Idiopathic Arthritis (JIA) treated with TCZ.

Settore MED/38 - Pediatria Generale E Specialisticatocilizumab Rheumatoid Arthritis Juvenile Idiopathic Arthritis
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RHEUMATOID ARTHRITIS INDUCED BY INTRA-ARTICULAR INJECTION OF COMPLETE FREUND’S ADJUVANT ALTERS THE EXPRESSION OF VARIOUS HSPS IN THE DIFFERENT REGION…

2023

Spinal cordHeat shock proteinGlutamate&nbspNeurogenic inflammationRheumatoid Arthritireceptors
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Mycobacterium tuberculosis Immune Response in Patients With Immune-Mediated Inflammatory Disease

2021

Subjects with immune-mediated inflammatory diseases (IMID), such as rheumatoid arthritis (RA), have an intrinsic higher probability to develop active-tuberculosis (TB) compared to the general population. The risk ranges from 2.0 to 8.9 in RA patients not receiving therapies. According to the WHO, the RA prevalence varies between 0.3% and 1% and is more common in women and in developed countries. Therefore, the identification and treatment of TB infection (TBI) in this fragile population is important to propose the TB preventive therapy. We aimed to study the M. tuberculosis (Mtb) specific T-cell response to find immune biomarkers of Mtb burden or Mtb clearance in patients with different TB …

TuberculosisImmunologyPopulationchemical and pharmacologic phenomenaDiseaseMycobacterium tuberculosisImmune systemmedicineM. tuberculosisImmunology and AllergyCytotoxic T celleducationIFN-γCD27Original Researcheducation.field_of_studybiologybusiness.industryRC581-607bacterial infections and mycosesmedicine.diseasebiology.organism_classificationtuberculosisRheumatoid arthritisImmunologyTumor necrosis factor alphaImmunologic diseases. Allergybusinessimmune-mediated inflammatory disease
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