Search results for "rhinosinusiti"

showing 10 items of 21 documents

Canine fossa puncture in endoscopic sinus surgery: report of two cases

2017

Abstract Introduction Chronic rhinosinusitis with nasal polyposis is a common chronic disease that often affects maxillary sinus. Endoscopic sinus surgery is the most common procedure for treating the majority of maxillary sinus lesions. Objective To demonstrate the role of canine fossa puncture during endoscopic sinus surgery procedure in patients with severe maxillary sinus disease. Methods We present 2 cases where canine fossa puncture has been performed as method to obtain a complete access to the maxillary antrum. Results According our experience, 2 cases on 296 endoscopic sinus surgery (0.6%) where antrostomy and used of angled microdebrider were not sufficient, canine fossa puncture …

medicine.medical_specialtyMaxillary sinusChronic rhinosinusitissinusitisCanine fossa punctureMiddle meatal antrostomyPuncturesMaxillary antrumMaxillary sinusYoung Adult03 medical and health sciencesNasal Polyps0302 clinical medicineMaxillary sinusitisotorhinolaryngologic diseasesmedicineHumansIn patient030223 otorhinolaryngologyAgedMaxillary sinus sinusitis Maxillary sinusitisAlternative methodsAngled microdebriderbusiness.industryOtorhinolaryngology2734 Pathology and Forensic MedicineEndoscopylcsh:Otorhinolaryngologylcsh:RF1-547SurgeryEndoscopic sinus surgerymedicine.anatomical_structureChronic diseaseOtorhinolaryngologyCanine fossaAngled microdebrider; Canine fossa puncture; Maxillary sinusitis; Middle meatal antrostomy; Otorhinolaryngology2734 Pathology and Forensic MedicineChronic DiseaseFemaleTomography X-Ray Computedbusiness030217 neurology & neurosurgery
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Clarithromycin in the Management of Chronic Rhinosinusitis: Preliminary Results of a Possible Its New Use

2018

The aim of this study is to evaluate the efficacy and safety of prolonged therapy with low-dose clarithromycin in patients with chronic rhinosinusitis with polyps (CRSwP) after endoscopic sinus surgery (ESS). A total of 10 patients with CRSwP were identified and subjected to bilateral ESS. In post-operative patients they were treated with nasal wash with saline solution and steroid sprays (beclomethasone). During follow-up, after 30–40 days after the operation (M = 35.4 SD = +4.33), patients reported a worsening of symptoms with onset of nasal obstruction; reduction/loss of smell; headache; onset of viscous secretions and therefore all patients continued therapy with saline nasal irrigation…

medicine.medical_specialtymedicine.medical_treatmentMucous membrane of noseEosinophilGastroenterology03 medical and health sciences0302 clinical medicineHyposmiaEdemaInternal medicineClarithromycinClarithromycinmedicineChronic rhinosinusitis with polyp030223 otorhinolaryngologyTopical Steroid TherapySalineNosebusiness.industryOtorhinolaryngology2734 Pathology and Forensic MedicineChronic rhinosinusitis with polypsSurgerymedicine.anatomical_structureOtorhinolaryngologyOtorhinolaryngology030220 oncology & carcinogenesisOriginal ArticleSurgeryChronic rhinosinusitis with polyps; Clarithromycin; Eosinophilmedicine.symptombusinessmedicine.drug
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THE LINKAGE BETWEEN UPPER RESPIRATORY TRACT INFECTIONS AND OTITIS MEDIA: EVIDENCE OF THE 'UNITED AIRWAYS CONCEPT'

2012

Upper respiratory tract infection (URTI) is a nonspecific term used to describe acute infections involving the nose, paranasal sinuses, pharynx and larynx and resulting from interplay between microbial load (viral and bacterial) and immune response. Infant and young children are prone to developing upper respiratory tract infections, which often result in bacterial complications especially acute otitis media because of the passage of bacteria (colonizing the nasopharynx) in the middle ear via Eustachian tube.

Upper respiratory tract infections rhinosinusitis otitis media.
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Inter-society consensus for the use of inhaled corticosteroids in infants, children and adolescents with airway diseases

2021

Abstract Background In 2019, a multidisciplinary panel of experts from eight Italian scientific paediatric societies developed a consensus document for the use of inhaled corticosteroids in the management and prevention of the most common paediatric airways disorders. The aim is to provide healthcare providers with a multidisciplinary document including indications useful in the clinical practice. The consensus document was intended to be addressed to paediatricians who work in the Paediatric Divisions, the Primary Care Services and the Emergency Departments, as well as to Residents or PhD students, paediatric nurses and specialists or consultants in paediatric pulmonology, allergy, infecti…

MaleDelphi TechniqueRhinosinusitisRespiratory Tract DiseasesDelphi methodRhinosinusitiLaryngitisAdrenal Cortex HormonePediatrics0302 clinical medicineAdrenal Cortex HormonesMultidisciplinary approachInhaled corticosteroid030212 general & internal medicineChildRespiratory Tract DiseaseRhinitiSocieties MedicalRhinitiseducation.field_of_studyInhaled corticosteroidsWheezing.General MedicineSettore MED/38Systematic reviewItalyLaryngotracheitisChild PreschoolLaryngotracheitiFemalemedicine.symptomHumanmedicine.medical_specialtyConsensusAdolescentPopulationConsensuRJ1-57003 medical and health sciencesIntervention (counseling)Administration InhalationmedicineLaryngospasmHumansAdenoid hypertrophyLaryngospasmeducationIntensive care medicineAsthmaWheezingbusiness.industryResearchInfantmedicine.diseaseAsthma030228 respiratory systemAdenoid hypertrophy; Asthma; Inhaled corticosteroids; Laryngospasm; Laryngotracheitis; Rhinitis; Rhinosinusitis; Wheezingbusiness
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Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis – A EUFOREA-ARIA-EPOS-AIRWAYS IC…

2017

Precision medicine (PM) is increasingly recognized as the way forward for optimizing patient care. Introduced in the field of oncology, it is now considered of major interest in other medical domains like allergy and chronic airway diseases, which face an urgent need to improve the level of disease control, enhance patient satisfaction and increase effectiveness of preventive interventions. The combination of personalized care, prediction of treatment success, prevention of disease and patient participation in the elaboration of the treatment plan is expected to substantially improve the therapeutic approach for individuals suffering from chronic disabling conditions. Given the emerging dat…

allergic rhinitis; integrated care pathway; precision medicine; rhinosinusitisAllergyRhinosinusitisDiseaseAllergic rhinitis0302 clinical medicineQUALITY-OF-LIFEMedicineImmunology and Allergy030223 otorhinolaryngologySinusitisNASAL POLYPOSISRhinitisPrecision medicineintegrated care pathway3. Good healthAlgorithmREAL-LIFEIMPACT OUTCOMESARIA and EPOS working groups1107 ImmunologyDISEASESGA(2)LENDisease Progressionallergic rhinitiLife Sciences & BiomedicineENDOSCOPIC SINUS SURGERYAlgorithmsHumanIntegrated care pathwayallergic rhinitis; integrated care pathway; precision medicine; rhinosinusitis; Adult; Algorithms; Chronic Disease; Disease Progression; Humans; Precision Medicine; Rhinitis Allergic; Sinusitis; Young Adult; Immunology and Allergy; ImmunologyAdultmedicine.medical_specialtyprecision medicineImmunologyrhinosinusitiPHENOTYPESVALIDATIONYoung Adult03 medical and health sciencesTherapeutic approachAllergicPatient satisfactionQuality of life (healthcare)HumansSinusitisPatient participationIMMUNOTHERAPYIntensive care medicinerhinosinusitisAsthmaScience & Technologyallergic rhinitis; integrated care pathway; precision medicine; rhinosinusitis; Immunology and Allergy; Immunologyallergic rhinitisbusiness.industrymedicine.diseasePrecision medicineSinusitiRhinitis AllergicSEVERITY030228 respiratory system3121 General medicine internal medicine and other clinical medicineChronic DiseasePhysical therapyASTHMAbusiness
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Effects of Omalizumab Treatment in Patients With Recalcitrant Nasal Polyposis and Mild Asthma: A Multicenter Retrospective Study

2021

Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a clinical entity with specific features that impacts significantly on patient quality of life (QoL). CRSwNP is often associated with asthma and is difficult to control and manage despite pharmacological and/or surgical treatment. Omalizumab, a monoclonal anti-IgE antibody, has emerged as a putative therapeutic option. Objective To evaluate the effects of omalizumab on nasal polyp (NP) size and QoL assessed by Sino-Nasal Outcome Test-22 (SNOT-22) in patients with recalcitrant CRSwNP and mild asthma. Methods A multicenter retrospective analysis of patient data from the Community of Valencia (Spain) was performed. Adult patients …

Adultmedicine.medical_specialtyMild asthmaOmalizumabOmalizumabaspirin-exacerbated respiratory diseasechronic rhinosinusitis with nasal polypsImmunoglobulin E03 medical and health sciencesNasal Polyps0302 clinical medicineQuality of lifeSNOT-22Internal medicinemedicineHumansImmunology and AllergyNasal polypsIn patient030223 otorhinolaryngologyRetrospective StudiesRhinitisnasal polypsbiologybusiness.industrytotal nasal endoscopic polyp scoreRetrospective cohort studyGeneral Medicinemedicine.diseaseAsthmaTreatment Outcomequality of lifetissue eosinophilia030228 respiratory systemOtorhinolaryngologyIgE SNOT-22 aspirin-exacerbated respiratory disease chronic rhinosinusitis with nasal polyps mild asthma nasal polyps omalizumab quality of life tissue eosinophilia total nasal endoscopic polyp scoreChronic DiseaseQuality of Lifebiology.proteinomalizumabAspirin exacerbated respiratory diseaseIgEbusinessmild asthmamedicine.drugAmerican Journal of Rhinology & Allergy
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Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI)

2020

According to the data derived from several national and international registries, including SANI (Severe Asthma Network Italy), and considering the strong impact that frequent or regular use of oral corticosteroid has on quality of life (QoL) of severe asthmatics, as well as on the costs for managing corticosteroid-related diseases, oral corticosteroid sparing up to withdrawal should be considered a primary outcome in the management of severe asthma. New biologics have clearly demonstrated that this effect is possible, with concomitant reduction in the rate of exacerbations and in symptom control. Then, there is no reason for using so frequently oral corticosteroid before having explored al…

ISAR International Severe Asthma RegistrySHARPPediatricsSevere asthmaSA severe asthmaBiologics Oral corticosteroids Real-life Registr Severe asthmaOmalizumabforced expiratory volume in the 1st secondFood &ampGrading of Recommendations Assessmentchronic rhinosinusitis with nasal polyposisFEV1chemistry.chemical_compound0302 clinical medicineQuality of lifeEMAReal WorldEuropean Medicines AgencyBiologics; Oral corticosteroids; Real-life; Registr; Severe asthmaOral corticosteroidsFDA Food & Drug AdministrationImmunology and Allergy030223 otorhinolaryngologySevere Heterogeneous Asthma Research collaborationmusculoskeletal neural and ocular physiologyReal-lifeCRSwNPOCSsBenralizumabDupilumabCRSwNP chronic rhinosinusitis with nasal polyposisGRADESHARP Severe Heterogeneous Asthma Research collaboration Patient-centredSevere Asthma Network in ItalyFDAmedicine.drugPulmonary and Respiratory Medicinelcsh:Immunologic diseases. Allergymedicine.medical_specialtyDrug AdministrationGINA Global Initiative for AsthmaRW Real WorldImmunologymacromolecular substancesRWSettore MED/10 - Malattie Dell'Apparato RespiratorioBiologicsInternational Severe Asthma RegistryISAR03 medical and health sciencesSADisease registrySARP Severe Asthma Research ProgramPatient-centredmedicineAsthmabusiness.industrySettore MED/09 - MEDICINA INTERNASANI Severe Asthma Network in ItalySANIBiological productmedicine.diseaseOCSs Oral CorticoSteroidsGINASARPSevere Asthma Research ProgramFEV1 forced expiratory volume in the 1st second030228 respiratory systemchemistrynervous systemRegistrEMA European Medicines AgencyDevelopment and EvaluationSevere asthma Biologics Oral corticosteroids Real-life Registrbusinesslcsh:RC581-607Global Initiative for AsthmaMepolizumabGRADE Grading of Recommendations Assessment Development and Evaluation
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Current Concepts in Therapy of Chronic Rhinosinusitis and Nasal Polyposis

2004

The exact pathophysiological mechanisms leading to chronic rhinosinusitis (CRS) still to a large extent remain obscure. However, recently there has been some progress in elucidating the etiology of nasal polyposis, especially regarding tissue eosinophilia as well as the role of aspirin intolerance and eicosanoid mediators. Endonasal sinus surgery has evolved to be the treatment of choice in CRS and nasal polyposis in all cases where conservative treatment has failed or resulted in only a partial or temporary relief. Today, state of the art in surgical technique includes the ability to combine microscopic and endoscopic procedures. Regardless of technical advances like powered instrumentatio…

medicine.medical_specialtyAntifungal AgentsChronic rhinosinusitisNasal PolypsPostoperative ComplicationsEosinophiliaParanasal Sinusesotorhinolaryngologic diseasesmedicineHumansEosinophiliaNasal polypsSinusitisSinusitisRhinitisAspirinmedicine.diagnostic_testbusiness.industryEndoscopyrespiratory systemmedicine.diseaseAnti-Bacterial AgentsEndoscopySurgeryConservative treatmentTreatment OutcomeSurgery Computer-AssistedOtorhinolaryngologyChronic DiseaseHistamine H1 AntagonistsEtiologySteroidsASPIRIN INTOLERANCEmedicine.symptombusinessORL
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Treg activation and their role in different subtypes of chronic rhinosinusitis

2020

Chronic rhinosinusitisbusiness.industryChronic DiseaseImmunologyImmunologyMEDLINEHumansImmunology and AllergyMedicineSinusitisbusinessT-Lymphocytes RegulatoryRhinitisAllergy
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MUC4 impairs the anti-inflammatory effects of corticosteroids in patients with chronic rhinosinusitis with nasal polyps

2017

Background Current evidence suggests that membrane-tethered mucins could mediate corticosteroid efficacy, interacting with glucocorticoid receptor (GR) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Mucin 4 (MUC4)–tethered mucin is expressed in nasal polyp (NP) epithelial cells and upregulated under inflammatory conditions. Moreover, MUC4β has the capacity to interact with other intracellular proteins. We hypothesized that MUC4 modulates corticosteroid efficacy of patients with CRSwNP. Objective We sought to analyze the role of MUC4 in corticosteroid effectiveness in different cohorts of patients with CRSwNP and elucidate the possible mechanisms involved. Methods Eighty…

AdultMale0301 basic medicineSmall interfering RNAmedicine.drug_classImmunologyAnti-Inflammatory AgentsDrug ResistanceBiologyDexamethasoneCell LineYoung Adult03 medical and health sciencesNasal PolypsGlucocorticoid receptorPregnenedionesmedicineglucocorticoid receptorHumansImmunology and AllergyNasal polypsSinusitisCells CulturedDexamethasoneAgedRhinitisnasal polypGene knockdownMucin-4chronic rhinosinusitisMucincorticosteroid resistanceEpithelial CellsMiddle Agedmedicine.diseaseHEK293 Cells030104 developmental biologyMUC4Chronic DiseaseImmunologyCorticosteroidImmunohistochemistryFemalesense organsmedicine.drug
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