Search results for "rito"
showing 10 items of 2948 documents
Vinblastine-induced autophagocytosis: effects on liver glycogen
1983
The possible similarities of the mechanism by which vinblastine induces autophagocytosis in liver were compared with the known effects of glucagon in glucagon-induced autophagocytosis. A single intraperitoneal injection of vinblastine produced a wave of autophagocytosis in less than 0.5 h in mouse hepatocytes. Liver glycogen content decreases simultaneously and blood glucose first increased and then decreased below control values. Both liver cAMP concentration and the activity of glycogen phosphorylase remained unchanged. These findings provide evidence that the induction of autophagocytosis after vinblastine injection is not mediated by cAMP. The increased degradation of glycogen may occur…
Vascular Dysfunction in Experimental Diabetes Is Improved by Pentaerithrityl Tetranitrate but Not Isosorbide-5-Mononitrate Therapy
2011
OBJECTIVE Diabetes is associated with vascular oxidative stress, activation of NADPH oxidase, and uncoupling of nitric oxide (NO) synthase (endothelial NO synthase [eNOS]). Pentaerithrityl tetranitrate (PETN) is an organic nitrate with potent antioxidant properties via induction of heme oxygenase-1 (HO-1). We tested whether treatment with PETN improves vascular dysfunction in the setting of experimental diabetes. RESEARCH DESIGN AND METHODS After induction of hyperglycemia by streptozotocin (STZ) injection (60 mg/kg i.v.), PETN (15 mg/kg/day p.o.) or isosorbide-5-mononitrate (ISMN; 75 mg/kg/day p.o.) was fed to Wistar rats for 7 weeks. Oxidative stress was assessed by optical methods and o…
Intraportal transplantation of allogenic pancreatic islets encapsulated in barium alginate beads in diabetic rats.
2003
The survival of microencapsulated islets transplanted into the unmodified peritoneal cavity is limited, even if capsular overgrowth is restricted to a minimum, due to an insufficient oxygen supply to the islets. Therefore, research efforts should focus on finding or creating a transplantation site, which permits a closer contact between the encapsulated islets and the blood. For this reason, the liver could be an interesting candidate. The aim of the present study was to test the hypothesis that the intraportal transplantation of allogenic islets encapsulated in small-sized barium alginate beads is safe and succeeds to induce normoglycemia in diabetic rats. The intraportal transplantation o…
Enhanced platelet thromboxane synthesis and reduced macrophage-dependent fibrinolytic activity related to oxidative stress in oral contraceptive-trea…
1996
Abstract In previous studies conducted in rats and in women, we have shown that oral contraceptive (OC) administration induced a platelet hyperaggregation simultaneously with an increased platelet lipid biosynthesis which might be related to lipid peroxidation. In the present study, we specifically studied the arachidonic acid and the fibrinolytic pathways in relation to the fatty acid composition in female rats treated for 6 weeks with OC (ethinyl estradiol plus lynestrenol). We found that platelets of treated animals were not only hyper-responsive to thrombin and ADP, but also to sodium arachidonate. In addition, the results of the thrombin-induced release of labeled arachidonic acid pre-…
Efecto de la profundidad del bloqueo neuromuscular sobre el espacio abdominal y las condiciones quirúrgicas durante la cirugía laparoscópica abdomina…
2017
Introducción: La anestesia aparece como un factor clave en el desarrollo del proceso asistencial de la cirugía laparoscópica, por su capacidad de actuar tanto sobre los factores barrera que condicionan el período postoperatorio y el alta hospitalaria precoz, como por la posibilidad de influir en la optimización de las condiciones quirúrgicas. Sin embargo, mientras que existen recomendaciones con una evidencia científica de grado A en cuanto a intervenciones sobre el control de las náuseas/vómitos postoperatorios(NVPO), estrategias para el control del dolor postquirúrgico o para la mejora en la calidad de la recuperación postoperatoria, la evidencia científica presente hasta el momento en re…
Heme oxygenase-1 induction and regulation in unstimulated mouse peritoneal macrophages
2003
Heme oxygenase-1 (HO-1) is a stress protein induced by a variety of stimuli in inflammatory cells. This study was set up to investigate the induction of this protein in unstimulated macrophages. Resident mouse peritoneal macrophages purified by adhesion and cultured in basal conditions strongly induced HO-1 in a time-dependent manner, with a peak at 20 hr. At the same time, low levels of nitrite accumulated in the culture medium and expression of nitric oxide synthase-2 (NOS-2) and NOS-3 protein was detected. Inhibition of NO production and/or NOS expression by incubating macrophages with different drugs inhibiting NOS activity or modulating the redox state of the cell, such as N-acetylcyst…
Territorial tripolarization in Bolivia : genesis and current situation
2012
The Bolivian urban system is outstanding : three major cities concentrate about half of the nation’s population and employment. Their territories’ trajectories lead us to question their economic role in the face of the successful economic achievement of Potosi and Tarija, territories well endowed in natural resources. We wanted to highlight the Bolivian current territorial tripolarization, firstly by studying its emergence, through the study of their economical history; secondly, by investigating the most recent economical data in order to display the strengths and weaknesses of this tripolarized system. Each component of the tripole is situated in a different geographical setting. In the W…
Preoperative preparation of «loss of domain» hernia. Progressive pneumoperitoneum and botulinum toxin type A.
2017
Preoperative progressive pneumoperitoneum and botulinum toxin type A are useful tools in the preparation of patients with loss of domain hernias. Both procedures are complementary in the surgical repair, especially with the use of prosthetic techniques without tension, that allow a integral management of these patients. The aim of this paper is to update concepts related to both procedures, emphasizing the advantages that take place in the preoperative management of loss of domain hernias.
Dépôts de bronzes et relations visuelles autour du Camp du Château à Salins-les-Bains (Jura, France) à la fin du Bronze moyen et au début du Bronze f…
2017
Systematic field surveys have been carried out in the surroundings of the Camp du Château near Salins-les-Bains for several years. These investigations led to the discovery of forty-odd hoards dating mainly from the end of the Middle Bronze Age and the beginning of the Late Bronze Age. The good accuracy of their localization allows us to study how they were integrated into the landscape. Their positioning suggests that the choice of location favored topographical criteria. We are interested in the question of intervisibility between the place of hoarding and the remarkable points of the natural and social landscape, especially the hill-forts. The results of GIS analysis show the constitutio…
ArchaeDyn. Dynamique spatiale du peuplement et ressources naturelles : vers une analyse intégrée dans le long terme, de la Préhistoire au Moyen Âge,.…
2008
Rapport de fin de contrat d'ACI