Search results for "rotu"
showing 10 items of 642 documents
Histamine and spontaneously released mast cell granules affect the cell growth of human hepatocellular carcinoma cells
2007
The role of mast cells in tumor growth is still controversial. In this study we analyzed the effects of both histamine and pre-formed mediators spontaneously released by mast cells on the growth of two human hepatocellular carcinoma cell lines, HA22T/VGH and HuH-6, with different characteristics of differentiation, biological behavior and genetic defects. We showed that total mast cell releasate, exocytosed granules (granule remnants) and histamine reduced cell viability and proliferation in HuH-6 cells. In contrast, in HA22T/VGH cells granule remnants and histamine induced a weak but significant increase in cell growth. We showed that both cell lines expressed histamine receptors H(1) and …
Double localization and multiple recurrences of dermatofibrosarcoma protuberans of the female breast: a rare clinical case.
2015
Not available
US in the assessment of acute scrotum
2013
Abstract Background The acute scrotum is a medical emergency . The acute scrotum is defined as scrotal pain, swelling, and redness of acute onset. Scrotal abnormalities can be divided into three groups , which are extra-testicular lesion, intra-testicular lesion and trauma. This is a retrospective analysis of 164 ultrasound examination performed in patient arriving in the emergency room for scrotal pain. The objective of this article is to familiarize the reader with the US features of the most common and some of the least common scrotal lesions. Methods Between January 2008 and January 2010, 164 patients aged few month and older with scrotal symptoms, who underwent scrotal ultrasonography …
Transformacja połączeń rtęć - substancje humusowe przy udziale Pleurotus ostreatus
2013
Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex.
2012
Expansion of CAG repeats is a common feature of various neurodegenerative disorders, including Huntington's disease. Here we show that expanded CAG repeats bind to a translation regulatory protein complex containing MID1, protein phosphatase 2A and 40S ribosomal S6 kinase. Binding of the MID1-protein phosphatase 2A protein complex increases with CAG repeat size and stimulates translation of the CAG repeat expansion containing messenger RNA in a MID1-, protein phosphatase 2A- and mammalian target of rapamycin-dependent manner. Our data indicate that pathological CAG repeat expansions upregulate protein translation leading to an overproduction of aberrant protein and suggest that the MID1-com…
The E3 Ubiquitin Ligase MID1 Catalyzes Ubiquitination and Cleavage of Fu
2014
Sonic Hedgehog (SHH)-GLI signalling plays an important role during embryogenesis and in tumorigenesis. The survival and growth of several types of cancer depend on autonomously activated SHH-GLI signalling. A protein complex containing the ubiquitin-ligase MID1 and protein phosphatase 2A (PP2A) regulates the nuclear localization and transcriptional activity of GLI3, a transcriptional effector molecule of SHH, in cancer cell lines with autonomously activated SHH signalling. However, the exact molecular mechanisms that mediate the interaction between MID1 and GLI3 remained unknown. Here, we show that MID1 catalyses the ubiquitination and proteasomal cleavage of the GLI3-regulator Fu. Our data…
Le Fratture di Rotula
2015
Patellar fractures are relatively uncommon, accounting for approximately 1% of all fractures. Non-operative treatment represents the best choice for undisplaced patellar fractures. However, surgery becomes necessary when fractures are displaced by more than 2 mm, and may include open reduction and internal fixation. Accurate reduction and rigid fixation are required in order to allow early knee mobilization and to obtain a better clinical outcome. Several techniques have been described for patellar fracture fixation, such as tension band wiring, interfragmentary screw fixation, and the combination of screw fixation and cerclage. In this article up-to-date diagnosis, classification and treat…
Trait Variation between Two Wild Specimens of Pleurotus ostreatus and Their Progeny in the Context of Usefulness in Nematode Control
2022
Pleurotus ostreatus is one of the most widespread mushrooms in the world. It is a valuable and widely cultivated edible mushroom with nematicidal properties. The mycelium of this mushroom produces a toxin that paralyzes nematodes, after which the nematode becomes infected with the filament, resulting in its death. This feature can be put to practical use as a natural nematicidal agent. In this paper, we have described studies on two wild strains of P. ostreatus (PO1, PO2) and the monokaryotic progeny obtained from their fruiting bodies. Monokaryons were crossed with each other within the progeny of one strain (PO1xPO1; PO2xPO2) and of two different strains (PO2xPO1). The growth conditions, …
Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity
2021
Centrioles comprise the heart of centrosomes, microtubule-organizing centers. To study the function of centrioles in lung and gut development, we genetically disrupted centrioles throughout the mouse endoderm. Surprisingly, removing centrioles from the endoderm did not disrupt intestinal growth or development but blocked lung branching. In the lung, acentriolar SOX2-expressing airway epithelial cells apoptosed. Loss of centrioles activated p53, and removing p53 restored survival of SOX2-expressing cells, lung branching, and mouse viability. To investigate how endodermal p53 activation specifically killed acentriolar SOX2-expressing cells, we assessed ERK, a prosurvival cue. ERK was active t…