Search results for "régulateur"
showing 8 items of 8 documents
Study of molecular mechanisms of stress response in Oenococcus oeni and implementation of tools for the functional exploration of enological genes
2015
O. oeni is responsible for wine malolactic fermentation. As any organism, O. oeni tries to adapt its physiology to environmental fluctuations by producing Hsp proteins encoded by the hsp genes. In O. oeni, CtsR is currently the only regulator of hsp genes. As an alternative to the lack of genetic tool, with the goal of understanding the mechanisms of O. oeni stress response, we developed a new expression vector, the pSIPSYN, to produce antisense RNA targeting of hsp18 mRNA. The synthesis of hsp18 asRNA leads to the decrease in the protein level of Lo18 and induced a loss of cultivability after heat or acid shock showing for the first time in vivo involvement of Lo18 in thermotolerance and a…
Le pouvoir royal (1814-1848). A la recherche du quatrième pouvoir ?
2021
This work sheds light on the representations of royal power that confronted each other until 1848 to fulfil the programme of reconciliation of the "two France" wanted by Louis XVIII. They are divided between the desire to return to the Ancien Régime and the attempt to renew the royal function. Opposed to the ultraroyalists, the supporters of this original path wished to consecrate liberal constitutionalism by resorting to an unexpected expedient, the power of the King, which had to be remodelled. As with Constant and Dunoyer, it was a question of creating a fourth power with its own essence and a new mission: to watch over the institutions. This regulating or preserving power produced a pas…
Pesticides sur blé tendre d'hiver, diversité dans le détail
2013
Contexte -L’analyse des pratiques d’application des pesticides (herbicides, fongicides, insecticides, ré-gulateurs) sur le blé tendre d’hiver (BTH) a été réalisée à partir de données d’en-quêtes annuelles sur une petite zone agricole en Côte-d’Or. Etude - L’étude a porté sur 294 parcelles appar-tenant à 13 exploitants pour la période 2004-2011. L’indice retenu pour carac-tériser l’usage des pesti-cides est l’IFT (indice de fréquence de traitements).
Effects of adjuvants of the cholera toxin family on CD4 + T cell responses in a murine model of intrarectal immunization with rotavirus-like particles
2011
Mucosal immunization is an important goal of vaccine development to protect against pathogens that use mucosa as portals of entry. However, the use of non-replicating antigens requires the addition of adjuvants.Cholera-like enterotoxins, cholera toxin (CT) from Vibrio cholerae and the heat-labile enterotoxin (LT) from toxinogenic strains of E. coli, as well as the mutant LR-192G and their B subunits (CTB and LTB) have been shown to increase immune responses against unrelated co-administered antigens by mucosal routes. However, their mechanism of action is very complex and not completely understood and differences exist between holotoxins and B subunits and within molecules, differences exis…
Etude physiopathologique de la réponse immunitaire au cours de la thrombopénie immunologique (purpura thrombopénique immunologique)
2010
Immune thrombocytopenia (ITP) is an autoimmune disease responsible for a peripheral immune destruction of platelets associated with an inappropriate bone marrow production. In this work, we first review the mechanisms involved in the pathogenesis of ITP. We also focus on the T cell immune response, highlighting the key role of regulatory T cells (Treg) in peripheral tolerance. The implication of the spleen in the immune response and the effects of rituximab, a B cell depleting therapy, are discussed. Then, our results obtained from 40 ITP patients are reported. Despite the fact that CD4+CD25HighFoxp3+ circulating Treg levels are similar between patients and controls, a significant increase …
Aspects fonctionnels et pronostiques des cellules myéloïdes suppressives et de Foxp3 dans le cancer
2011
Evasion of immune surveillance by certain tumour cells seems to be a basic requirement for tumour development in preclinical models and in humans. The mechanisms by which the tumour mediates its immune evasion are manifold, and involve the majority of immune system cells. Among these, immunoregulatory cells such as myeloid-derived suppressor cells (MDSCs) or regulatory T lymphocytes (T-regs, which express the transcription factor Foxp3) appear to play a predominant role. The results presented in this work aim to improve our understanding of the functional and prognostic roles of myeloid suppressor cells and T-regs in cancer, focussing particularly on how these cells are modulated by chemoth…
La question de l'accessibilité dans les décisions des médecins régulateurs des centres 15
2010
National audience
Reflexions on the introduction of the vocabulary of regulation in the field of law during the XVIIIth century and on its contemporary use
2017
According to a recurring lesson, the vocabulary of regulation would be of late introduction in the law language. Indeed, law professors substantiate this theory, conveyed by the sociologists : this word family would have first been introduced by the social sciences at the end of the XIXth century, before any use by the world of law. The present study tends, on the contrary, to demonstrate the existence and the continuity of the idea of regulation in law since the introduction, in the XVIIIth century, of the polysemous figure of the regulator ; a two-headed figure, applied as well to a power as to a judicial institution and to law, which separates and sometimes involves the regulation of a m…