Search results for "sage"
showing 10 items of 1373 documents
Weekly Cisplatin and Volumetric-Modulated Arc Therapy With Simultaneous Integrated Boost for Radical Treatment of Advanced Cervical Cancer in Elderly…
2016
Background: To evaluate the feasibility and clinical preliminary results of weekly cisplatin and volumetric-modulated arc therapy to the pelvis with simultaneous integrated boost to macroscopic disease in a cohort of elderly patients. Materials and Methods: Inclusion criteria of this prospective study were age ≥70 years, Karnofsky performance status 70 to 100, locally advanced histologically proven squamous cervical carcinoma, and patients unable to undergo brachytherapy. Radiation doses prescribed were 66 Gy to the macroscopic disease and 54 Gy to the pelvic nodes in 30 fractions. Weekly cisplatin dose was 40 mg/mq. Results: A total of 30 patients were recruited. Median follow-up was 32 mo…
Bioadhesive monolayer film for the in vitro transdermal delivery of sumatriptan
2006
The work presented here aims to develop a bioadhesive monolayer film containing sumatriptan as adjuvant for the treatment of headache pain in a severe migraine attack. Permeation experiments were performed from the films prepared and from the respective solution, to evaluate the relevant permeation parameters. The effect of the penetration enhancers Transcutol, 2-pyrrolidone, and polyethylene glycol 600 was evaluated. The results obtained show that Transcutol and 2-pyrrolidone decreased sumatriptan permeation from solution, whereas a modest increase was produced by polyethylene glycol 600. The enhancers produced the same effects when they were included in the film. Compared to solution, the…
The influence of Span®20 on stratum corneum lipids in Langmuir monolayers: comparison with Azone®
2000
Recently we have proved that Span 20 has the same enhancer effect as Azone on in vitro percutaneous penetration of lipophilic compounds (logP(oct) from 1.34 to 2.33). The purpose of this work is to study the interactions of Span 20 with stratum corneum lipids monolayers and to compare them with Azone. The surface pressure-area characteristics of Span 20 in mixed monolayers with different model lipids (ceramides, cholesterol, free fatty acids and two mixtures of ceramides+cholesterol, and ceramides+cholesterol+free fatty acids) in similar proportions to that which exists in human stratum corneum lipids were recorded as compression isotherms at 25 degrees C. Azone was also investigated on mon…
Dosimetry comparison between TG-43 and Monte Carlo calculations using the Freiburg flap for skin high-dose-rate brachytherapy
2012
Abstract Purpose The purpose of this work was to evaluate whether the delivered dose to the skin surface and at the prescription depth when using a Freiburg flap applicator is in agreement with the one predicted by the treatment planning system (TPS) using the TG-43 dose-calculation formalism. Methods and Materials Monte Carlo (MC) simulations and radiochromic film measurements have been performed to obtain dose distributions with the source located at the center of one of the spheres and between two spheres. Primary and scatter dose contributions were evaluated to understand the role played by the scatter component. A standard treatment plan was generated using MC- and TG-43-based TPS appl…
Correction factors for ionization chamber measurements with the ‘Valencia’ and ‘large field Valencia’ brachytherapy applicators
2018
Treatment of small skin lesions using HDR brachytherapy applicators is a widely used technique. The shielded applicators currently available in clinical practice are based on a tungsten-alloy cup that collimates the source-emitted radiation into a small region, hence protecting nearby tissues. The goal of this manuscript is to evaluate the correction factors required for dose measurements with a plane-parallel ionization chamber typically used in clinical brachytherapy for the 'Valencia' and 'large field Valencia' shielded applicators. Monte Carlo simulations have been performed using the PENELOPE-2014 system to determine the absorbed dose deposited in a water phantom and in the chamber act…
Contribution of Multi-Agent Systems and Fuzzy logic to support tutors in Learning Communities
2016
The growing importance of online training has put emphasis on the role of remote tutoring. A whole new area of research, dedicated to environment for human learning (EHL), is emerging. We are concerned with this field. More specifically, we will focus on the monitoring of learners.The instrumentation and observation of learners activities by exploiting interaction traces in the EHL and the development of indicators can help tutors to monitor activities of learners and support them in their collaborative learning process. Indeed, in a learning situation, the teacher needs to observe the behavior of learners in order to build an idea about their involvement, preferences and learning styles so…
L’influence des facteurs stratégiques et organisationnels sur les relations entre contrôle de gestion environnemental et apprentissage organisationne…
2020
Cet article étudie les relations entre contrôle de gestion environnemental (CGE) et apprentissage organisationnel (AO) en inscrivant le modèle de Simons (1995) dans une perspective contingente. Par des facteurs stratégiques et organisationnels, ce modèle enrichi explique les liens entre les modes de contrôle (diagnostique et interactif) de Simons et les niveaux d’apprentissage (en simple et double boucle) d’Argyris et Schön (1978). S’appuyant sur le « cas révélateur » d’une éco-PME missionnaire, l’étude montre l’influence de trois facteurs (valeurs fortes, stratégie proactive, cycle de vie des activités) sur les quatre configurations relationnelles CGE-AO et ouvre de nouvelles perspectives …
Comment évaluer et mesurer la conflictualité liée aux usages de l'espace ? Eléments de méthode et de repérage
2010
Cet article a pour objet de présenter le travail réalisé depuis quelques années par une équipe pluridisciplinaire sur la question des conflits d’usage de l’espace et de révéler la méthodologie d’enquête et de collecte de données, ainsi que la structure de la base de données qui en est issue. Dans un premier temps nous procédons à une définition du champ des investigations, en donnant une définition de ces conflits, de leurs caractéristiques, des mobiles et des manifestations de la conflictualité, ainsi que des acteurs impliqués (I). Nous exposons ensuite notre méthode de repérage des conflits, fondée sur un diagnostic de zone et la mise en commun de différentes méthodes de recueil de donnée…
Production of written French skills by first generation immigrants in working age
2013
This paper aims to identify factors explaining the level of proficiency in written French by immigrants in working age, knowing that few research has been conducted in France on this issue. The originality of this paper is the stochastic production frontier model to explain the scores in written French and the productive performance of immigrants (considered as producers of their own skills). The main results show that mother tongue, age at immigration, social life and mother's diploma are elements which influence the effectiveness of this production. They play a crucial role in the ability of immigrants to use effectively their duration of stay in France and their length of education, cons…
Predictors of enhancing human physical attractiveness: Data from 93 countries
2022
People across the world and throughout history have gone to great lengths to enhance their physical appearance. Evolutionary psychologists and ethologists have largely attempted to explain this phenomenon via mating preferences and strategies. Here, we test one of the most popular evolutionary hypotheses for beauty-enhancing behaviors, drawn from mating market and parasite stress perspectives, in a large cross-cultural sample. We also test hypotheses drawn from other influential and non-mutually exclusive theoretical frameworks, from biosocial role theory to a cultural media perspective. Survey data from 93,158 human participants across 93 countries provide evidence that behaviors such as a…