Search results for "sang"
showing 10 items of 428 documents
ACP Journal Club. Warfarin thromboprophylaxis in cancer did not reduce risk for catheter-related thrombosis.
2009
¿Me voy o me quedo? Factores que influyen en la decisión de abandonar el lugar de nacimiento.
2014
Múltiples factores influyen en la decisión de dispersarse y en cuándo iniciar la dispersión, y su estudio proporciona evidencias de las causas y los determinantes de la dispersión. Los animales abandonan el lugar de nacimiento para dar solución a tres problemas fundamentales: pérdida de calidad del hábitat, competencia por los recursos, y riesgo de consanguinidad. La dispersión, sin embargo, no se lleva a cabo hasta que los individuos alcanzan una condición física adecuada, que permita alcanzar con éxito un nuevo lugar de asentamiento.
Inhibition of Rho modulates cytokine-induced prostaglandin E2 formation in renal mesangial cells.
2003
Stimulation of rat mesangial cells for 24 h with interleukin-1β(IL-1β) plus forskolin (Fk) leads to a marked increase in prostaglandin E 2 (PGE 2 ) synthesis. This effect is further enhanced by the small G-protein Rho inhibitor toxin A. A similar increase in PGE 2 formation is obtained with Y27632, a Rho-dependent kinase inhibitor, and with lovastatin, a hydroxymethylglutaryl-coenzyme A inhibitor which depletes cells from geranylgeranyl moieties and thus blocks Rho activation. In parallel to the increased PGE 2 synthesis, a potentiation of IL-1β-induced secretory group IIA phospholipases A 2 (sPLA 2 -IIA) protein expression also occurs by Rho inhibition. However, only toxin A triggers an in…
Antígenos histo-sanguíneos e infección por rotavirus
2019
La infección por rotavirus es la principal causa de gastroenteritis aguda en niños menores de 5 años en todo el mundo. Su incidencia es similar en países desarrollados y en vías de desarrollo, aunque la mayor mortalidad ocurre en estos últimos. Las vacunas frente a rotavirus han demostrado una gran efectividad en los países industrializados, pero su protección es menor en los países del África subsahariana y Asia. Se ha descrito que los antígenos histo-sanguíneos, presentes en la membrana de los enterocitos, actúan como ligandos para distintos genotipos de rotavirus. Esto podría explicar las diferencias que se observan en su distribución geográfica y la distinta eficacia vacunal de unas áre…
BENDAMUSTINE IN ASSOCIATION WITH RITUXIMAB AS SALVAGE THERAPY FOR SPLENIC MARGINAL ZONE LYMPHOMA
2010
At present, a prospectively validated treatment for SMZL is lacking. Despite this fact, splenectomy is still deemed to be the best choice for patients requiring treatment. Nevertheless, the high fraction of patients achieving a clinical response following splenectomy eventually relapses or progresses
Superficial venous thrombosis: role of inherited deficiency of natural anticoagulants in extension to deep veins
2009
AIM: Superficial venous thrombosis (SVT) has been considered for a long time a limited clinical condition of low importance, but this approach has changed in recent years, when several studies demonstrated that extension to deep veins occurs in 7.3 to 44% of patients, with high prevalence of pulmonary embolism. The aim of this study was to evaluate the prevalence of inherited deficiency of natural coagulation inhibitors in patients suffering from SVT in both normal and varicose veins, and to understand their role in extension to deep veins. METHODS: The study included 83 patients with SVT, without clinically obvious risk factors. Ultrasound examination was performed, and deficiencies of Pro…
La destrucció del patrimoni artístic i la seua reconstrucció. Un exercici de microhistòria: el cas de Llíria i la Confraria de la Sang (1936-1949)
2020
The problem of artistic destruction and its reconstruction has been little studied. Using a microhistorical analysis method, we study the town of Lliria (Valencia) and its brotherhood of ?La Sang de Jesucrist? (had a great heritage from the 16th to the 19th centuries), and we also analyze how and why this destruction and reconstruction was generated during the context of the civil war. We use and combine different sources (public of the ?Causa General? and private of the ?Minute Books?) for this research, with the intention of specifying the analysis of this complex process. We also explain social and artistic relationships of these two processes, that help us study the workshops of the mos…
Extracellular Vesicle microRNAs Contribute to the Osteogenic Inhibition of Mesenchymal Stem Cells in Multiple Myeloma
2020
Osteolytic bone disease is the major complication associated with the progression of multiple myeloma (MM). Recently, extracellular vesicles (EVs) have emerged as mediators of MM-associated bone disease by inhibiting the osteogenic differentiation of human mesenchymal stem cells (hMSCs). Here, we investigated a correlation between the EV-mediated osteogenic inhibition and MM vesicle content, focusing on miRNAs. By the use of a MicroRNA Card, we identified a pool of miRNAs, highly expressed in EVs, from MM cell line (MM1.S EVs), expression of which was confirmed in EVs from bone marrow (BM) plasma of patients affected by smoldering myeloma (SMM) and MM. Notably,we found that miR-129-5p, whic…
Impacto del quimerismo hematopoyético precoz en el injerto tras trasplante alogénico de progenitores de sangre de cordón umbilical de donante no empa…
2013
El trasplante de sangre de cordón umbilical (TSCU) ha experimentado un auge muy importante en los últimos años como alternativa a la médula ósea y sangre periférica, debido a la dificultad de encontrar donantes altruistas de estas fuentes de progenitores hematopoyéticos. Los datos clínicos disponibles hasta la fecha muestran una supervivencia libre de enfermedad similar a la observada con el trasplante de médula ósea (TMO) o sangre periférica (TSP). Sin embargo, como consecuencia de la baja dosis celular contenida en la SCU, la tasa de fallo de injertos es más elevada y el tiempo hasta la recuperación de la neutropenia más prolongado. Gran parte de la investigación en el terreno del TSCU se…