Search results for "screening"

LO SCREENING PER L’IPOTIROIDISMO CONGENITO: DATI RETROSPETTIVI DEGLI ULTIMI 5 ANNI IN UN SINGOLO CENTRO

2018

Introduzione: L’incidenza dell’ipotiroidismo congenito (IC) in Italia varia da 1:2000-1:3000 nati. Il numero delle diagnosi è aumentato da quando il cut-off per il TSH su spot è stato ridotto, rispetto al valore di 10. Obiettivi: Lo studio si prefigge di raccogliere i dati del Centro Screening Neonatale dell’Ospedale dei Bambini “G. Di Cristina”, ARNAS Palermo, al quale pervengono i prelievi di tutti i nati nella Sicilia occidentale, al fine di valutare l’incidenza dell’IC. Materiali e Metodi: Da gennaio 2013 a dicembre 2017, sono stati screenati 79.699 neonati, tramite determinazione del TSH su spot. I neonati con TSH 6mU/L sono stati richiamati per dosare fT4, fT3, TSH, Ab anti-TG e anti-…

La sordità: screening genetico

2007

Traducción y validación preliminar del Cuestionario de Adicción al Sexo en jóvenes

2016

Sex addiction is a pathology that starts in the adolescence or the early adulthood and has an important impact on social and personal development. Early detection is a key issue, so the aim of this study was to adapt and validate one of the most employed questionnaires for its assessment: the Sexual Addiction Screening Test. For this purpose, 600 young people completed the study surveys. Through a factor analysis, we found that the SAST was composed by 4 subscales that explained 38.38% of the variance. Furthermore, reliability and convergent validity values supported its employment in the assessment of sex addiction. Therefore, SAST is now one of the available resources for the assessment o…

Spanish validation of the Sexual Addiction Screening Test.

2018

Background and aims Sexual addiction is a pathological behavior characterized by a combination of excessive sexual desire and impaired ability to control it. Its incidence ranges between 1.2% and 32.2%, although this number may vary depending on the screening tool used. This wide variability is largely due to the use of non-validated instruments (e.g., structural validity relying on exploratory analyses, instruments translated without an additional validation process, or instruments validated in another format). To deal with these limitations, this study tested the psychometric properties of the Spanish paper-and-pencil and online versions of the Sexual Addiction Screening Test (SAST). Met…

Application of molecular topology to the prediction of antiparasitic activity against Giardia intestinalis and Trichomonas vaginalis of 2-Acylamino-n…

2020

Giardia intestinalis y Trichomonas vaginalis destacan por su importancia clínica. G. intestinalis causa la giardiosis, una parasitosis de gran importancia epidemiológica y clínica por presentar una elevada prevalencia. T. vaginalis causa la tricomoniasis, la enfermedad de transmisión sexual (ETS) no viral con mayor incidencia del mundo. Ambas parasitosis comparten el mismo tratamiento farmacológico: los nitroimidazoles. Se ha aplicado la topología molecular en la búsqueda de derivados del 2-Acylamino-nitro-1,3-tiazol con actividad antiparasitaria frente a G. intestinalis y T. vaginalis . Con el análisis lineal discriminante se obtuvo un modelo capaz de clasificar correctamente el 92,85 % de…

Discovery of novel trichomonacidals using LDA-driven QSAR models and bond-based bilinear indices as molecular descriptors

2008

Few years ago, the World Health Organization estimated the number of adults with trichomoniasis at 170 million worldwide, more than the combined numbers for gonorrhea, syphilis, and chlamydia. To combat this sexually transmitted disease, Metronidazole (MTZ) has emerged, since 1959, as a powerful drug for the systematic treatment of infected patients. However, increasing resistance to MTZ, adverse effects associated to high-dose MTZ therapies and very expensive conventional technologies related to the development of new trichomonacidals necessitate novel computational methods that shorten the drug discovery pipeline. Therefore, bond-based bilinear indices, new 2-D bond-based TOMOCOMD-CARDD M…

Advanced Statistical Tools for Six Sigma and other Industrial Applications

Six Sigma is a methodological approach and philosophy for quality improvement in operations management; its main objectives are identifying and removing the causes of defects, and minimizing variability in manufacturing and business processes. To do so, Six Sigma combines managerial and statistical tools, with the creation of a dedicated organizational structure. In this doctoral thesis and the three years of study and research, we have had the purpose to advance the potential applications of the methodology and its tools; with a specific attention on issues and challenges that typically prevent the realization of the expected financial and operational gains that a company pursue in applyin…

Dispersive solid-phase extraction based on oleic acid-coated magnetic nanoparticles followed by gas chromatography-mass spectrometry for UV-filter de…

2011

Abstract A sensitive analytical method to concentrate and determine extensively used UV filters in cosmetic products at (ultra)trace levels in water samples is presented. The method is based on a sample treatment using dispersive solid-phase extraction (dSPE) with laboratory-made chemisorbed oleic acid-coated cobalt ferrite (CoFe 2 O 4 @oleic acid) magnetic nanoparticles (MNPs) as optimized sorbent for the target analytes. The variables involved in dSPE were studied and optimized in terms of sensitivity, and the optimum conditions were: mass of sorbent, 100 mg; donor phase volume, 75 mL; pH, 3; and sodium chloride concentration, 30% (w/v). After dSPE, the MNPs were eluted twice with 1.5 mL …

Pyrocoll, an Antibiotic, Antiparasitic and Antitumor Compound Produced by a Novel Alkaliphilic Streptomyces Strain

2003

A new secondary metabolite was detected in the culture extract of Streptomyces sp. AK 409 by HPLC-diode-array screening. The metabolite was identified as pyrocoll, which is known to be a constituent of cigarette smoke. Pyrocoll is known as a synthetic compound, but until now had not been isolated as a natural product from a microorganism. The compound showed biological activity against various Arthrobacter strains, filamentous fungi, several pathogenic protozoa, and some human tumor cell lines.

Discovery and structure-activity relationship studies of irreversible benzisothiazolinone-based inhibitors against Staphylococcus aureus sortase A tr…

2014

Gram-positive bacteria, in general, and staphylococci, in particular, are the widespread cause of nosocomial and community-acquired infections. The rapid evolvement of strains resistant to antibiotics currently in use is a serious challenge. Novel antimicrobial compounds have to be developed to fight these resistant bacteria, and sortase A, a bacterial cell wall enzyme, is a promising target for novel therapies. As a transpeptidase that covalently attaches various virulence factors to the cell surface, this enzyme plays a crucial role in the ability of bacteria to invade the host's tissues and to escape the immune response. In this study we have screened a small molecule library against rec…